Have a question about CBD? You’re not alone — we receive dozens of questions via email everyday, and have put together a list of the most common questions people ask to help you out.
People look to CBD for its long list of health benefits — but there are many layers to this cannabinoid.
We answer our readers’ most common questions regarding CBD below. If you have specific questions you’d like to have answered, make sure to send us a note through our contact page so we can get to the bottom of it.
Now let’s get started.
CBD is short for cannabidiol. It’s a non-psychoactive cannabinoid and the primary therapeutic agent in the cannabis plant. It can be used to support a variety of different symptoms and conditions — including epilepsy, anxiety, pain, inflammation, and poor immune function.
Each year, new research is released on CBD and its many benefits on the human body — which is what has lead to CBD becoming so popular in recent years as a health supplement.
Cannabinoids are a class of chemicals that interact with our endocannabinoid system.
There are three main types of cannabinoids;
The body makes two primary endocannabinoids (anandamide and 2-AG), the cannabis plant makes about 113 different phytocannabinoids, and there are thousands of synthetic cannabinoids.
Although all cannabinoids interact with the endocannabinoid system to some degree — each one has a unique set of characteristics and effects on the human body.
Terpenes are small, volatile compounds found throughout the plant world. Most plants we associate with an aroma owe this effect to their terpene content.
Pine trees, citrus fruits, roses, and cannabis are all notoriously high in terpenes — which is what gives each of these plants their characteristic aromas. Some of these terpenes are shared by plants unrelated to each other.
For example, cannabis shares terpenes with many other plant species, including pine, lavender, eucalyptus, nutmeg, mint, and more — giving its aroma touches of these botanicals as well.
Terpenes offer therapeutic benefits of their own, further lending to the overall medicinal effects of the cannabis plant as a whole. Some terpenes improve absorption of other molecules through the digestive tract, and many others are anti-inflammatory, sedative, or antibacterial.
The endocannabinoid system is a critical regulator of our nervous, immune, and endocrine systems. Tiny receptors called endocannabinoid receptors are located around the body and designed to send and receive chemical messages that control pain, inflammation, immune function, and nervous system activation.
THC, the psychoactive component of the cannabis plant, more closely resembles 2-AG, triggering the endocannabinoid receptors associated with serotonin in the brain — which is what gives it psychoactive effects.
CBD, on the other hand, is more closely related to anandamide — which acts as more of a regulator for the endocannabinoid system, supporting homeostasis of various organs throughout the body.
CBD oil can be made in several different ways:
The traditional method is to simply soak the dried flowers and leaves of cannabis plants in a carrier oil like olive or coconut oil, for several weeks. The medicinal components contained in the leaves diffuse into the oil over time. After a few weeks, the oil is strained to remove the fiber and cell structures of the plant— trapping the medicinal components of the plant in the oil.
Modern CBD oils are made a little differently.
First, the medicinal compounds in the cannabis plant are extracted through high-tech supercritical CO2 or chemical solvents. These extraction methods are much more efficient than oil — leading to more of the medicinal cannabinoids, terpenes, and other phytochemicals getting pulled out of the cannabis plant.
The extracts are then dissolved into an oil.
In some cases, an additional purification step is done to isolate pure CBD from the other cannabinoids and terpenes before going into the oil.
Throughout most of the world, the psychoactive cannabinoid THC is considered illegal. It’s this compound that drug tests look for — not CBD.
CBD is completely non-psychoactive and legal in most countries. Therefore, it’s unlikely that a drug test will search for CBD content.
Most CBD oils are made from CBD isolates, which have no traceable amount of THC. You’re extremely unlikely to fail a drug test as a direct result of taking these oils.
Other CBD oils are made from full-spectrum extracts, which contain less than 0.3% THC (the legal limit in the United States). Even these products are extremely unlikely to cause a failure on a drug test — however, it remains a slight possibility.
If you’re worried about failing a drug test while taking CBD, you should seek out products made from CBD isolates and guaranteed to contain no THC.
Third-party testing is a simple and effective way for companies to provide customers with transparency about the products they sell and the claims they’re making about them.
The CBD industry remains highly unregulated. This is an improvement from the past — when useful compounds like CBD were outright banned.
However, the problem is that there are a lot of companies manufacturing poor quality CBD products and selling them to the public as a health supplement. These supplements are often contaminated with heavy metals or harmful chemicals like pesticides or preservatives. There are other companies selling CBD oil with an advertised potency that proves to be inaccurate when tested.
The solution to this is third-party testing.
Companies send samples of their products off to a lab where they’re tested for CBD potency and potentially dangerous substances.
These labs provide an official certificate showing the cannabinoid profiles, and presence or absence of any contaminants according to their own tests. Third-party labs hold the CBD supplier accountable to its claims and reduce the risk of the customer. It’s easier to believe the results of a lab that holds no stake in the sale of the product than the CBD company itself.
Imagine a company found contaminants in their oils — it’s not likely they’re going to volunteer this information to their customers. Although most companies test their own products for quality control, the ethical ones seek a stamp of approval from a third-party lab.
With the current state of the CBD market, which is completely void of government regulation and testing — we wouldn’t recommend going with a company that can’t show third-party test results to back up their claims. What do they have to hide?
CBD is absorbed through the lungs (when smoked or vaped), sublingual capillaries (when taken under the tongue), or through the small intestines (if eaten or taken orally). This can take anywhere from 5 minutes (smoking or vaping), to 45 minutes (taking CBD orally).
Once in the bloodstream, CBD travels around the body and interacts with the endocannabinoid system to exert its effects. CBD will also activate other receptors in the body like the vanilloid and adenosine receptors.
Over time, CBD molecules pass through the liver which metabolizes the compound into inactive and water-soluble forms so the kidneys can eliminate it from the body.
The liver converts CBD into various metabolites including 7-OH-CBD and 6-OH-CBD.
Over time, more CBD will be converted to inactive metabolites. The entire process can take a couple of days before all the CBD is completely out of the body — however, the effects tend to last about 6-8 hours before concentrations become too low in the blood to provide any noticeable effects.
Although cannabis remains illegal throughout most of the world, there have been a lot of movements in recent years to change outdated laws. Many countries now have medicinal cannabis laws regulating CBD products for those who need them.
Each country has its own processes for providing access to CBD. This can range from applying through medical institutions, to simply buying it online or in local shops. The laws are constantly changing, so be sure to look up your country’s laws before assuming it’s completely legal.
Other countries, such as Canada, Georgia, Spain, and Uruguay, have legalized cannabis — making products containing CBD and THC legal for recreational and medicinal use.
In most countries, the easiest way to buy CBD is online. Companies will ship your CBD products directly to your door.
In the United States, CBD is completely legal in all 50 states according to the 2018 Farm Bill. According to the bill, hemp is considered any Cannabis sativa plant containing less than 0.3% THC by dried weight.
Marijuana is therefore classified as any cannabis plant containing over 0.3% THC by dried weight.
In the United States, hemp and CBD oils are listed as dietary supplements rather than medicinal or recreational drugs. This means that anybody in the United States, even those without medical programs now have access to CBD oils and other CBD products — as long as they don’t contain more than 0.3% THC.
Full-spectrum CBD oils are made using an extract that maintains the naturally occurring cannabinoid profile of the cannabis plant. This includes other cannabinoids like CBG, CBC, CBN, as well as terpenes like pinene, Linalool, and limonene.
There are in fact hundreds of compounds other than CBD or THC found in the cannabis plant — each one offering its own effects on the body.
CBD products made from isolates tend to be cheaper, but have less broad-acting effects on the body than full-spectrum.
There’s another class of extracts not frequently talked about — known as controlled spectrum extracts.
Controlled spectrum is a term used to describe cannabis extracts that fall in the middle of a full-spectrum and an isolate.
They’re made by isolating each cannabinoid — usually CBD, CBC, CBG, CBN, and THC.
These isolates are then mixed together in a proprietary ratio for the final product. This practice gives the final product what looks like full-spectrum levels of cannabinoids, but is made manually. It allows manufacturers to maintain standardized ratios of each cannabinoid.
In basic terms, the cannabinoid profile is controlled by the manufacturer.
Terpenes are also commonly added to controlled spectrum extracts to further mimic the natural levels of the cannabis plant.
CBD is readily absorbed through the lungs and will provide the same benefits to the body as oral use.
However, there are some key differences between inhaling CBD and taking it orally. For example, if using CBD for gastrointestinal complaints, or inflammation, oral consumption is much better. This is because taking the compound orally delivers the CBD and other compounds to the digestive tract directly, and doesn’t trigger the same inflammatory response as smoking.
Smoking, no matter what the substance is, triggers inflammation and introduces harmful byproducts throughout the body — namely carbon monoxide and hydrocarbons as a result of the combustion process.
Hemp and marijuana are the same species of plant — Cannabis sativa. Like other plants, cannabis has many different forms (called phenotypes) depending on its genetic lineage and growing environments. One plant can vary in phytochemical makeup substantially from the next.
Officially, hemp is any plant that contains less than 0.3% THC by dried weight, while marijuana is any cannabis plant containing more than 0.3% THC. Hemp is considered completely legal in the United States and much of the world, while marijuana is generally considered illegal due to its potential for psychoactive effects.
These differences in chemical profiles — even among the same species — is actually very common in the plant kingdom. Think about tomatoes — all tomatoes are considered to be the species Solanum lycopersicum, yet there are hundreds of different types of tomatoes available. Large, sweet beefsteak tomatoes, all the way to small dark-colored tomatoes.
Cannabis is the same — each phenotype is considered a different strain, even though it’s the exact same species.
There are two other species of marijuana as well — Cannabis indica and Cannabis ruderalis. These species are always classified as marijuana rather than hemp.
There are many different forms of CBD including:
We provide a lot more depth on each form of CBD — highlighting when to use them, when to avoid them, and how to find the best products in each category.
Overall, the best form of CBD will vary from one person to the next depending on the symptoms and personal preference:
Other options like bath bombs, CBD shots, low potency oils, gummies, edibles, teas, and coffee are less reliable for more serious symptoms. It can be difficult to reach the therapeutic dosage with these options, and other ingredients like added sugar may negatively affect the body in larger doses.
CBD is generally regarded as being safe and has a low potential for interacting with other drugs or supplements.
However, there are some exceptions to this rule.
The main issue CBD may pose with other medications involves the liver. The liver is responsible for metabolizing all kinds of compounds from the body, including naturally made ones like hormones or blood cells.
When we take large amounts of CBD that overwhelm the liver, it can cause other compounds that follow the same path of metabolism to become backed up. This can cause the effects of these drugs to last longer than expected — increasing the chances of producing side-effects.
Each drug is metabolized by different enzymes in the liver. If you’re planning to use CBD in combination with other medications, we recommend asking your doctor if there are any known drug interactions with CBD. You can also lookup the enzymes involved with metabolizing these drugs and compare it to the known enzymes involved with CBD metabolism.
Other drugs may interact with CBD if they work off any of the same pathways. This can include adenosine inhibitors, endocannabinoid agonists or antagonists, or opioid medications.
Always consult your doctor before taking CBD alongside other medications.
The dose of CBD can significantly vary from one person to the next. Recommended doses can range from 5 mg per day, up to 150 mg per day or more.
Whenever using CBD for the first time, we suggest you go low and slow. Start at the lowest dose of around 5 mg per day, and build up gradually over the course of a couple of weeks.
For some symptoms, you’ll know right away when you’ve reached the right dose when your symptoms are relieved. Other times the benefits of CBD can take several weeks, so we recommend building up to the suggested dose of CBD according to your weight and desired level of effects, and keeping it consistent for a few weeks. During this time, monitor your symptoms and adjust the dose accordingly.
CBD is not psychoactive — meaning that it won’t produce a high, even in very large doses.
Most products marketed for CBD won’t contain more than 0.3% THC, keeping them well below the psychoactive threshold.
However, there are a lot of products that contain THC in psychoactive doses, especially in countries where cannabis is legal.
It’s important to always double-check the THC content of products before you buy them. Anything claiming to be THC-free, or less than 0.3% THC can be taken without worrying about getting high.
Other cannabinoids to watch out for to avoid psychoactive effects are THCV, THCVA, and THCA.
Water-soluble CBD does not occur in nature. Using high-tech ultrasonic frequency machines, fat-soluble compounds like CBD can be converted into small, water-soluble spheres called liposomes. The process is referred to as nano-emulsion.
Many companies are suggesting that liposomal CBD (water-soluble CBD) is more readily absorbed through the digestive tract — however, no data actually confirms this. At this time, water-soluble extracts aren’t considered to offer any benefits on absorption and exist merely as a marketing tool.
CBD has very few side-effects, and the ones it produces are usually very mild.
With that said, there are some side-effects possible when using CBD, especially in higher doses, or in especially sensitive individuals.
CBD has a very long half-life of 1-2 days, but the effects will usually last around 6-12 hours.
Half-life is the time it takes for exactly half of a compound to be metabolized and eliminated from the bloodstream. It’s a measurement used to predict how long an active dose of a compound like CBD or pharmaceutical medications will last, and how often follow up doses can be taken.
With a long half-life from CBD, the concentration of the drug will gradually build up in the body over time — giving the CBD longer-lasting effects the longer you take it.
Yes! Animals also have endocannabinoid systems just like humans.
CBD offers your pets many of the same benefits. Consider using CBD to manage your pets’ pain, inflammation, stiff muscles and joints, anxiety, and appetite.
As you search for CBD, you’ll see that most companies offer a few products made for pets including tinctures, capsules, and treats.
Pets tend to be quite a bit smaller than humans. As a result, they usually require significantly less CBD than what you might need. The best companies offer advice on how to safely dose CBD for your pets.
Animals may not react well to THC, so it’s especially important to look for products that have a low or 0% THC content.
The short answer is no. Even in high doses, CBD has been shown to be non-lethal.
However, taking too much CBD may increase the risk of the side-effects listed above. You may feel lethargic and drowsy, which may impair your ability to operate machinery.
The short answer is no. CBD itself is not addictive and has a low likelihood of producing tolerance or physical dependence — especially compared to alternative analgesics or antianxiety medications like opioids or benzodiazepines.
However, CBD can become habit-forming as people begin to rely on the supplement as a source of relief from their symptoms. When the CBD begins to wear off, many users will desire to take another dose to alleviate their symptoms again.
This is very different than a physical addiction, however.
During a physical addiction, the body loses its ability to maintain homeostasis without the drug — causing severe withdrawal symptoms whenever the drug is no longer in the system. This doesn’t happen with CBD — the worst that will happen if you stop taking it, even after many years of use, is that your symptoms may begin to reappear.
CBD interacts with the following receptors/enzymes in the body:
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