Does CBD Interact With Mirodenafil (Mvix)?

Does CBD Interact With Mirodenafil (Mvix)?

Yes. CBD can interact with mirodenafil.

CBD’s interaction with mirodenafil is considered mild, with low chances of serious side effects as long as the two drugs are taken in low dosage. With long-term use, however, mirodenafil can pile up in the body, becoming more potent, but also cause more side effects like prolonged and painful erections, headaches, back pain, etc. 

CBD can interact with mirodenafil in two main ways:

A) CBD May Interfere With The Body’s Ability to Metabolize Mirodenafil

A metabolic inhibition happens when two substances compete against each other because they both get metabolized by the same enzymes. This causes them to accumulate in the body in more than the necessary amount, causing more side effects. 

Mirodenafil gets metabolized by the CYP3A4 enzyme, the same ones that CBD needs for metabolism too. Taking them together causes an excess accumulation of mirodenafil and makes its side effects worse. It may also take more time for mirodenafil to be metabolized from the body due to a slow down in its elimination. 

B) CBD May Increase the Risk of Side Effects of Mirodenafil

Agonistic interaction happens when similar effects are exerted by two substances in the body. This makes such effects more potent and may end up becoming abnormal and excess in the body. 

Mirodenafil acts on the phosphodiesterase 5 (PDE5) receptors in the body. This drug inhibits PDE5’s actions, effectively causing vasodilation and causing an erection. CBD, on the other hand, acts on the endocannabinoid and serotonergic receptors. It may also cause dilation of blood vessels. So taking these two together may worsen some side effects of mirodenafil like headaches, flushing, increased heart rate, etc. 

Similar Medications: CBD & Erectile Dysfunction Medications

Mirodenafil is classified as a phosphodiesterase inhibitor. CBD and erectile dysfunction medications all share similar risks for interaction and side effects. It is used for treating erectile dysfunction (ED). 

Here’s a list of similar medications that share a similar level of risk when combined with CBD:

• Sildenafil (Viagra)
• Tadalafil (Cialis)
• Vardenafil (Levitra, Staxyn, and Vivanza)
• Avanafil (Stendra)
• Udenafil (Zydena)

Is It Safe to Take CBD & Mirodenafil (Mvix) Together?

CBD and mirodenafil have mild chances of interaction. So a mild dose of both the drugs taken for a short duration may be safe to use. 

However, taking them for a longer duration or taking larger doses of both drugs may cause an overaccumulation of mirodenafil in the body, slowing down its metabolism as well. This could be potentially dangerous. 

Take these medications only after getting a proper consultation from your physician. Do not overdose on them. If you get any unusual side effects, get in touch with your medical practitioner at once. 

Is CBD A Viable Alternative to Mirodenafil (Mvix)?

While CBD does offer some (indirect) benefits on erectile dysfunction, it has an entirely different mechanism of action and is therefore not considered a viable alternative to mirodenafil. 

CBD can cause many different kinds of effects on erectile dysfunction and libido. Sometimes it can improve them, while in others it can worsen them too. 

A study conducted on male mice provided with CBD showed that their sexual behavior got impaired after administration of a long duration of CBD [1]. The provision of excess CBD seemed to impair and lower the sexual drive in these mice.  

Another study showed that chronic users of cannabis, CBD’s base ingredient, had more ED compared to nonusers [2]. 

However, CBD’s ability to relieve anxiety may help increase the libido in users with ED [3]. In some people, decreased level of libido may be because of their anxiety about their sexual performance. So treating may increase the sexual drive. 

Hence, CBD may help relieve milder cases of ED and decreased libido but cannot be considered a perfect alternative to mirodenafil yet. 

What is Mirodenafil (Mvix)? 

Mirodenafil is a phosphodiesterase type 5 (PDE5) inhibitor. It was developed by SK chemical lab science and is sold mostly in Korea. Mvix is its only brand to date. It’s used to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). 

It has not yet been approved for use by the FDA in the west.

Mirodenafil (Mvix) Specs:

Other Names For Mirodenafil (Mvix)

Mirodenafil has only one brand name to date, called Mvix.  

What Does Mirodenafil (Mvix) Do?

Mirodenafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by stopping the work of cGMP (cyclic guanosine monophosphate)-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells present in the blood vessels in different kinds of tissues.  

PDE5 is mainly found in corpora cavernosa, vascular smooth muscles, visceral smooth muscles, and platelets.

Mirodenafil causes erection by increasing the blood flow to a flaccid penis. During sexual intercourse, after an adequate amount of foreplay, there will be a release of nitric oxide (NO) from nerve terminals and endothelial cells. This releases cyclic guanosine monophosphate (cGMP) as well.  

The cGMP’s release causes relaxation of the muscles of corpora cavernosa in the penis. It also dilates the blood vessels. It is followed by a rapid entry of blood into those vessels, causing engorgement of the penis, making it erect. The erection lasts until the end of the intercourse and until after ejaculation occurs.  

The enzyme PDE5 degrades the cGMP in the penis, preventing any major blood flow into the blood vessels. In most ED patients, the blood vessels in the penis are also affected and are unable to loosen up. These vessels may also have some obstructions in them. 

Mirodenafil inhibits PDE5, leading to an increased cGMP level in the corpus cavernosum. The penis will then have more blood flow, making it erect enough to have sex. 

There is a major catch to this, however. Mirodenafil needs proper sexual stimulation to work. 

It has a half-life of 2.5 hours, with a Tmax of 1.25 hours. It also has ten times more selectivity to PDE5 compared to other ED medications. It can also lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). Mirodenafil is not addictive and does not develop dependence.  

Side Effects of Mirodenafil (Mvix)

Mirodenafil has been reported to cause mild to moderate adverse effects [4,5]. The most common side effects are:

• Headaches
• Hot flushes
• Abnormal vision
• Back pain
• Diarrhea
• Muscle pain
• Prolonged and painful erection
• Skin rash
• Tingling sensation in the limbs and extremities

Contraindications of Using Mirodenafil (Mvix)

Mvix has a few contraindications that might make it ineffective or unsafe for use: 

1. It should not be used with medications such as nitrates, antihypertensive medications, guanylate cyclase stimulators, antacids, grapefruit products, CYP3A4 inhibitors, and CYP3A4 inducers
2. It is not recommended for use in women and children
3. It is not recommended for consumption along with alcohol
4.  It must be avoided in users with severe heart disease, hypersensitivity to mirodenafil, priapism, severe renal and liver disease, stomach ulcers, retinitis pigmentosa, and blood disorders.

Key Takeaways: Is it Safe to Take Mirodenafil (Mvix) With CBD?

Mirodenafil and CBD have a mild chance of interacting as long as they are taken within the recommended dosage range. To further minimize risk, it’s wise to separate the dose of mirodenafil and CBD by at least 2 hours.  

Large doses of both drugs taken for a longer time may slow down the metabolism of mirodenafil in the body, causing more side effects. 

Never take these two medications without consulting your medical practitioner first. 

References

1. Carvalho, R. K., Andersen, M. L., & Mazaro‐Costa, R. (2020). The effects of cannabidiol on male reproductive system: A literature review. Journal of Applied Toxicology, 40(1), 132-150. 
2. Pizzol, D., Demurtas, J., Stubbs, B., Soysal, P., Mason, C., Isik, A. T., … & Veronese, N. (2019). Relationship between cannabis use and erectile dysfunction: a systematic review and meta-analysis. American journal of men’s health, 13(6), 1557988319892464. 
3. Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836. 
4. Cho, M. C., & Paick, J. S. (2016). A review of the efficacy and safety of mirodenafil in the management of erectile dysfunction. Therapeutic advances in urology, 8(2), 100-117.
5. Park, H. J., Moon, K. H., Lee, S. W., Lee, W. K., Kam, S. C., Lee, J. H., & Park, N. C. (2014). Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. The World Journal of men’s health, 32(1), 18-27.