Fluoxetine (Prozac), is a common prescription SSRI medication used in the treatment of anxiety and depression.
There’s a moderate risk of CBD interacting with fluoxetine.
Unsurprisingly, there are a lot of people who take both CBD (cannabidiol) and SSRIs at the same time.
Is this combination safe? Are there any dangers to be aware of? We’ll explore the potential risks and interactions when combining CBD with fluoxetine (Prozac).
There is a moderate risk of increased side effects when using CBD with antidepressants such as fluoxetine (Prozac) .
The chances of users experiencing a serious interaction are low. However, some of the rare but possible side effects are severe — including seizures and serotonin syndrome.
There are two main ways CBD can interact with fluoxetine.
CBD strongly interacts with other drugs metabolized by CYP2C19 and moderately interacts with drugs metabolized by CYP2D6 .
Most SSRIs, including fluoxetine, are also metabolized by CYP2D6 . Fluoxetine is a moderate inhibitor of drugs metabolized by CYP2D6 but a strong inhibitor of drugs metabolized by CYP2C19.
Since CBD and fluoxetine compete for metabolism in the liver, serum levels of both compounds can elevate. This slows fluoxetine’s metabolization, which, in turn, increases the possibility of side effects.
Adverse effects from mixing CBD with fluoxetine include nausea, diarrhea, and headaches.
Simultaneously taking two substances with similar actions results in an agonistic interaction. CBD and fluoxetine may compound each other’s actions as they are both used to treat depression, anxiety, and panic disorders.
This interaction can result in serious side effects.
Therefore, before taking CBD and fluoxetine together, you must consult with your physician first. They may want to reduce your dose of Prozac or advise you to separate your dose of SSRIs and CBD by about 2-hours to minimize your risk.
Fluoxetine is a generic drug marketed under many different brand names. All of the following medicines share the same risk and potential for interaction with CBD.
Some of the other names for fluoxetine are:
Fluoxetine (Prozac) is classified as an SSRI drug. CBD and SSRIs interact and share the same risks.
Safety concerns with the co-administration of CBD and fluoxetine (Prozac) are still a topic of debate. Few studies exist on potential drug interactions between these two substances.
CBD and fluoxetine, when taken together, may lead to some undesirable side effects such as dizziness, drowsiness, difficulty in concentrating, and confusion. Older individuals may experience impairment in motor coordination along with judgment and thinking.
A lower dosage of fluoxetine, when taken with CBD, may have fewer side effects than higher dosages. However, it’s best to avoid the co-administration of CBD and fluoxetine.
Consult your doctor before you combine CBD with any other medication, including fluoxetine.
CBD could be a natural alternative in treating depression, substituting fluoxetine due to its similar effects, but it depends on what fluoxetine is prescribed for . If it’s for anything other than mild depression, CBD is unlikely to help. It appears to be better tolerated than routine psychiatric medications .
CBD has a low overall risk of side effects with short-term use compared to most antipsychotics. However, further research is needed to evaluate possible long-term dangers and damages.
However, do not stop taking fluoxetine or adjust the dose as it can lead to withdrawal symptoms. Always consult your physician first before switching between drugs or supplementing prescribed antidepressants with CBD.
Fluoxetine (Prozac) is a prescription-only medication belonging to the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. It is a generic drug with trade names such as Prozac, Rapiflux, Sarafem, Barazac, and Selfemra.
It’s the drug of choice in treating obsessive-compulsive disorders, panic disorders, social phobias, eating disorders, premenstrual dysphoric disorder, and post-traumatic stress disorder.
These drugs also treat anxiety and bipolar disorders, body dysmorphic disorder, compulsive buying, kleptomania, and premature ejaculation.
It’s for use in children seven years or older only and is available in dosages of 10 mg, 20 mg, 40 mg, and 90 mg capsules.
|Trade Names||Prozac, Rapiflux, Sarafem, Barazac, Selfemra, etc|
|Classification||Selective Serotonin Reuptake Inhibitor (SSRI)|
|CYP Metabolism||Metabolized by CYP2C19 and CYP2D6|
|Interaction with CBD||Metabolic Inhibitor and Agonistic Interaction|
|Risk of interaction||Moderate|
Fluoxetine (Prozac), belonging to the SSRI class of drugs, blocks serotonin’s reabsorption (reuptake) into neurons.
This leads to increased levels of serotonin in the brain. SSRIs mainly affect serotonin, not other neurotransmitters. Serotonin, famously known as the happy hormone, stabilizes our mood, feelings of well-being, and happiness.
These are the common and mild side effects of fluoxetine that usually disappear after a week of use.
The following are serious side effects that need immediate medical attention. Call your healthcare provider right away if you have any of these symptoms.
Besides side effects, there are other things to be aware of if you’re using fluoxetine.
Do not mix CBD or fluoxetine with alcohol. The adverse effects of both substances may be fatal when taken with alcohol.
Do not use fluoxetine if you have previously used monoamine oxidases (MAO) inhibitors such as phenelzine and tranylcypromine. It may lead to a condition known as serotonin syndrome, which is life-threatening.
Other drugs that increase serotonin levels include tricyclic antidepressants (TCA), triptans, amphetamine, methamphetamine, MDMA, buspirone, and serotonin-norepinephrine reuptake inhibitors.
Patients using blood-thinning medications should also avoid fluoxetine.
Opioids like pethidine, tramadol, dextromethorphan, and tapentadol will increase serotonergic activity. Fentanyl and methadone have similar effects but to a lesser degree.
A combination of opioids and fluoxetine may increase the risk of serotonin toxicity. Fluoxetine also blocks the metabolism of opioids leading to reduced analgesic effects .
Fluoxetine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus (Pregnancy Category C). It is not for use in breastfeeding women as fluoxetine is excreted in breast milk.
Dose adjustments are required in patients with liver cirrhosis; these patients need lower or less frequent dosing. Unlike other drugs, dose adjustment for fluoxetine is not necessary for patients with impaired renal functions.
Do not stop fluoxetine without talking to your healthcare provider. Stopping the drug suddenly may cause serious withdrawal symptoms such as anxiety, irritability, high or low mood, feeling restless, or changes in sleep habits. Other symptoms include headache, sweating, nausea, dizziness, electric shock-like sensations, shaking, and confusion.
CBD is a natural, relatively nontoxic chemical with antidepressant action. There is a moderate risk if you use CBD and fluoxetine (Prozac) together.
Adverse effects of co-administration include dizziness, drowsiness, difficulty in concentrating, and confusion.
Always consult with your healthcare provider to ensure that CBD does not interact with any medication you are currently taking.
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