{"id":12555,"date":"2022-07-20T15:40:26","date_gmt":"2022-07-20T13:40:26","guid":{"rendered":"https:\/\/dailycbd.com\/es\/?p=12555"},"modified":"2022-07-20T15:49:02","modified_gmt":"2022-07-20T13:49:02","slug":"investigacion","status":"publish","type":"post","link":"https:\/\/dailycbd.com\/es\/investigacion\/","title":{"rendered":"Listado completo de estudios de investigaci\u00f3n sobre el CBD"},"content":{"rendered":"\n<h2>Lista exhaustiva de investigaciones de Cannabidiol<\/h2>\n\n\n\n<p>Hasta la fecha, ha habido m\u00e1s de 15,000 estudios enfocados en el CBD.<\/p>\n\n\n\n<p>La mayor\u00eda de estos estudios son an\u00e1lisis moleculares e investigaciones <em>in vitro<\/em> que ofrecen evidencia limitada de los beneficios del CBD.<\/p>\n\n\n\n<p>Recientemente, ha habido un incremento dirigido hacia el desarrollo de estudios <em>in vivo<\/em> de alta calidad y ensayos cl\u00ednicos. Estos estudios son de suma importancia para el entendimiento acad\u00e9mico de los cannabinoides.<\/p>\n\n\n\n<p>Hoy en d\u00eda, el CBD ya no est\u00e1 estigmatizado y los estudios de investigaci\u00f3n han comprobado su seguridad. Ahora miramos hacia el futuro y nos preguntamos, \u201c\u00bfde qu\u00e9 es capaz el CBD?\u201d.<\/p>\n\n\n\n<p>\u00bfEl CBD realmente funciona? \u00bfExiste suficiente evidencia para respaldar los beneficios de salud de este cannabinoide?<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-1024x384.png\" alt=\"\" class=\"wp-image-12577\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/addiction-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y las adicciones<\/h2>\n\n\n\n<p><strong>Gracias a las investigaci\u00f3n, se han descubierto los siguientes efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/adiccion\/\">CBD para el control de las adicciones<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia los s\u00edntomas del s\u00edndrome de abstinencia<\/li><li>El CBD puede reducir los antojos de tabaco<br><\/li><li>Regula la funci\u00f3n de la dopamina en el cerebro<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios acerca del CBD y las adicciones:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26056464\/\">Cannabidiol as an intervention for addictive behaviors: a systematic review of the evidence.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26269227\/\">Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23685330\/\">Cannabidiol reduces cigarette consumption in tobacco smokers: preliminary findings.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20695034\/\">Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16489449\/\">Cannabidiol is an allosteric modulator at mu-and delta-opioid receptors.<\/a> (2006)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-1024x384.png\" alt=\"\" class=\"wp-image-12576\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/anxiety-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la ansiedad<\/h2>\n\n\n\n<p><strong>Seg\u00fan la evidencia actual disponible, estos son los beneficios del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/ansiedad-depresion\/\">CBD para la ansiedad<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Disminuye la inflamaci\u00f3n cerebral<\/li><li>Incrementa la funci\u00f3n del GABA en el cerebro<\/li><li>Promueve el sue\u00f1o restaurador<\/li><li>Reduce los niveles de cortisol<\/li><li>Regula la actividad de la serotonina y la dopamina<\/li><li>Relaja la musculatura tensa o contra\u00edda<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y la ansiedad:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32052321\/\">Study: Cannabidiol Holds Promise for Treating Psychosis<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30624194\/\">Cannabidiol in anxiety and sleep: a large case series.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30157131\/\">Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30624194\/\">Cannabidiol in Anxiety and Sleep: A Large Case Series.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30087591\/\">Cannabidiol as a therapeutic alternative for post-traumatic stress disorder: From bench research to confirmation in human trials.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29057454\/\">Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5\u2010HT1A receptor\u2010mediated suppression of nausea and anxiety in rats.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28268256\/\">Cannabidiol Regulation of Emotion and Emotional Memory Processing: Relevance for Treating Anxiety-related and Substance Abuse Disorders<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28861510\/\">Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28424834\/\">Effect of Prior Foot Shock Stress and Delta9-Tetrahydrocannabinol, Cannabidiolic Acid, and Cannabidiol on Anxiety-like Responding in the Light-dark Emergence Test in Rats<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28553229\/\">Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28268256\/\">Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety\u2010related and substance abuse disorders.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27768570\/\">Effects of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26341731\/\">Cannabidiol as a Potential Treatment for Anxiety Disorders<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26218440\/\">Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24923339\/\">Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23298518\/\">The Anxiolytic Effect of Cannabidiol on Chronically Stressed Mice Depends on Hippocampal Neurogenesis: Involvement of the Endocannabinoid System<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24137134\/\">Does cannabidiol protect against adverse psychological effects of THC?<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22729452\/\">Cannabidiol, a Cannabis Sativa Constituent, as an Anxiolytic Drug<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20829306\/\">Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21307846\/\">Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20829306\/\">Neural Basis of Anxiolytic Effects of Cannabidiol (CBD) in Generalized Social Anxiety Disorder: a Preliminary Report<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21307846\/\">Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-naive Social Phobia Patients<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19124693\/\">Distinct Effects of \u03949-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing.<\/a> (2009)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14583744\/\">Effects of cannabidiol (CBD) on regional cerebral blood flow.<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22290374\/\">Effects of ipsapirone and cannabidiol on human experimental anxiety.<\/a> (1993)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6285406\/\">Action of cannabidiol on the anxiety and other effects produced by \u0394 9-THC in normal subjects.<\/a> (1982)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-1024x384.png\" alt=\"\" class=\"wp-image-12575\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/arthritis-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la artritis<\/h2>\n\n\n\n<p><strong>Las investigaciones han encontrado los siguientes efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/artritis\/\">CBD para la artritis<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia la inflamaci\u00f3n subyacente<\/li><li>Mitiga el dolor cr\u00f3nico<\/li><li>Previene la infiltraci\u00f3n de c\u00e9lulas T en la artritis reumatoide<\/li><li>Promueve la recuperaci\u00f3n del tejido articular<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y la artritis:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30083539\/\">Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28885454\/\">Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21238581\/\">Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21683763\/\">The Abnormal Cannabidiol Analogue O-1602 Reduces Nociception in a Rat Model of Acute Arthritis Via the Putative Cannabinoid Receptor GPR55<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14963641\/\">Oral Anti-inflammatory Activity of Cannabidiol, a Non-psychoactive Constituent of Cannabis, in Acute Carrageenan-induced Inflammation in the Rat Paw<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10920191\/\">The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.<\/a> (2000)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-1024x384.png\" alt=\"\" class=\"wp-image-12574\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cancer-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y el c\u00e1ncer<\/h2>\n\n\n\n<p><strong>Las investigaciones han demostrado los siguientes efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/cancer\/\">CBD en pacientes con c\u00e1ncer<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia el dolor oncol\u00f3gico<\/li><li>Alivia la n\u00e1usea y el v\u00f3mito asociado a la quimioterapia<\/li><li>Apoya la ansiedad y la depresi\u00f3n asociada al diagn\u00f3stico del c\u00e1ncer<\/li><li>Enlentece el crecimiento tumoral<\/li><li>Incrementa los niveles de hambre<\/li><li>Promueve la duraci\u00f3n y la calidad del sue\u00f1o<\/li><li>Regula las c\u00e9lulas inmunol\u00f3gicas claves para la detecci\u00f3n del c\u00e1ncer<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y el c\u00e1ncer:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30815264\/\">Striking lung cancer response to self-administration of cannabidiol: A case report and literature review.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30660647\/\">Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31570484\/\">Concomitant Treatment of Malignant Brain Tumours With CBD \u2013 A Case Series and Review of the Literature.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30275207\/\">Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27586579\/\">Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24373545\/\">Inhibition of Colon Carcinogenesis by a Standardized Cannabis Sativa Extract With High Content of Cannabidiol<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22506672\/\">Cannabidiol as Potential Anticancer Drug<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24204703\/\">Cannabidiol, a Non-psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells Through a Multitarget Effect<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23079154\/\">Triggering of the Trpv2 Channel by Cannabidiol Sensitizes Glioblastoma Cells to Cytotoxic Chemotherapeutic Agents<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23141881\/\">An Open-label Extension Study to Investigate the Long-term Safety and Tolerability of THC\/CBD Oromucosal Spray and Oromucosal Thc Spray in Patients With Terminal Cancer-related Pain Refractory to Strong Opioid Analgesics<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22594963\/\">Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23220503\/\">COX-2 and PPAR-\u03b3 Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22506672\/\">Cannabidiol as potential anticancer drug.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23264851\/\">Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma-associated Herpesvirus-infected Endothelium<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22198381\/\">Cannabidiol Inhibits Lung Cancer Cell Invasion and Metastasis Via Intercellular Adhesion Molecule-1<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23264851\/\">Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma\u2013Associated Herpesvirus-Infected Endothelium.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22231745\/\">Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21566064\/\">Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20859676\/\">Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21566064\/\">Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19896326\/\">Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20053780\/\">Cannabidiol enhances the inhibitory effects of \u03949-tetrahydrocannabinol on human glioblastoma cell proliferation and survival.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18387516\/\">A Comparative Study on Cannabidiol-induced Apoptosis in Murine Thymocytes and El-4 Thymoma Cells<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18025276\/\">Cannabidiol as a Novel Inhibitor of Id-1 Gene Expression in Aggressive Breast Cancer Cells<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16728591\/\">Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16754784\/\">Cannabidiol-induced Apoptosis in Human Leukemia Cells: a Novel Role of Cannabidiol in the Regulation of P22phox and Nox4 Expression<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14692532\/\">Gamma-irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured Hl-60 Myeloblastic Leukemia Cells<\/a> (2003)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-1024x384.png\" alt=\"\" class=\"wp-image-12573\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/diabetes-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la diabetes<\/h2>\n\n\n\n<p><strong>La evidencia actual demuestra los siguientes beneficios del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/diabetes\/\">CBD para la diabetes<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia el dolor neurop\u00e1tico<\/li><li>Alivia otros efectos secundarios de la diabetes<\/li><li>Ayuda a suprimir el apetito y disminuir el peso<\/li><li>Mejora la cicatrizaci\u00f3n de heridas<\/li><li>Mejora la funci\u00f3n de la insulina<\/li><li>Protege el h\u00edgado<\/li><li>Protege las c\u00e9lulas pancre\u00e1ticas secretoras de insulina<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios acerca del CBD y la diabetes:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32210914\/\">The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30898678\/\">Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27573936\/\">Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25212218\/\">Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20806080\/\">Cannabidiol Protects Retinal Neurons by Preserving Glutamine Synthetase Activity in Diabetes<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21144973\/\">Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17714746\/\">Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16698671\/\">Cannabidiol Lowers Incidence of Diabetes in Non-obese Diabetic Mice<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16400026\/\">Neuroprotective and Blood-retinal Barrier-preserving Effects of Cannabidiol in Experimental Diabetes<\/a> (2006)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-1024x384.png\" alt=\"\" class=\"wp-image-12572\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/epilepsy-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la epilepsia<\/h2>\n\n\n\n<p><strong>Hasta la fecha, se han reportado los siguientes efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/epilepsia\/\">CBD para la epilepsia<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia la neuroinflamaci\u00f3n<\/li><li>Alivia las convulsiones<\/li><li>Apoya la actividad del GABA<\/li><li>Modula los receptores clave en la regulaci\u00f3n de la salud cerebral<\/li><li>Protege las c\u00e9lulas nerviosas<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y la epilepsia:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32656346\">Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32096470\/\">Epilepsy and cannabidiol: a guide to treatment.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32169600\/\">Cannabidiol in treatment of refractory epileptic spasms: An open-label study.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32053110\/\">The proposed mechanisms of action of CBD in epilepsy.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32119035\/\">Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30917869\/\">Cost-effectiveness of cannabinoids for pediatric drug-resistant epilepsy: protocol for a systematic review of economic evaluations.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30921021\/\">Update on Antiepileptic Drugs 2019<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31067185\/\">Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31247132\/\">Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30515765\/\">Cannabis\u2010based products for pediatric epilepsy: A systematic review.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30582156\/\">Long\u2010term cannabidiol treatment in patients with Dravet syndrome: An open\u2010label extension trial.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30740695\/\">Cannabidiol in patients with Lennox\u2010Gastaut syndrome: Interim analysis of an open\u2010label extension study.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31382177\/\">Drug\u2013drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31067185\/\">Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30460546\/\">Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31372958\/\">Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31003195\/\">Quality of life in adults enrolled in an open-label study of cannabidiol (CBD) for treatment-resistant epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30258398\/\">Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29387536\/\">An interaction between warfarin and cannabidiol, a case report.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29395273\/\">Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30258395\/\">Cannabidiol for Treatment of Childhood Epilepsy\u2013A Cross-Sectional Survey.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29768152\/\">Effect of Cannabidiol on Drop Seizures in the Lennox\u2013Gastaut Syndrome.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30258398\/\">Potential clinical benefits of CBD-rich Cannabis extracts over purified cannabidiol (CBD) in treatment-resistant epilepsy: observational data meta-analysis.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28782097\/\">Interactions between cannabidiol and commonly used antiepileptic drugs.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28973916\/\">Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28089286\/\">Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29344464\/\">Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26800377\/\">CBD-enriched medical cannabis for intractable pediatric epilepsy: the current Israeli experience.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26724101\/\">Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26282273\/\">Cannabinoids and Epilepsy<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26114620\/\">Drug\u2013drug interaction between clobazam and cannabidiol in children with refractory epilepsy.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26352816\/\">Cannabinoids in the treatment of epilepsy.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25029033\/\">Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24854149\/\">The case for medical marijuana in epilepsy.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24854329\/\">Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19906779\/\">Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18354002\/\">Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6129147\/\">Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.<\/a> (1982)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7028792\/\">Hypnotic and Antiepileptic Effects of Cannabidiol.<\/a> (1981)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-1024x384.png\" alt=\"\" class=\"wp-image-12571\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ibd-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la enfermedad inflamatoria intestinal (EII)<\/h2>\n\n\n\n<p><strong>La evidencia cient\u00edfica ha demostrado los siguientes efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/colitis-crohn\/\">CBD en la EII<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia el dolor<\/li><li>Inhibe la inflamaci\u00f3n en el tracto digestivo<\/li><li>Mejora la diversidad de la flora intestinal<\/li><li>Previene la activaci\u00f3n de mastocitos<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y la EII:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29538683\/\">A randomized, double-blind, placebo-controlled, parallel-group, pilot study of cannabidiol-rich botanical extract in the symptomatic treatment of ulcerative colitis.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22815234\/\">Cannabidiol in inflammatory bowel diseases: a brief overview.<\/a> (2013)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-1024x384.png\" alt=\"\" class=\"wp-image-12570\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/migraine-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD, la migra\u00f1a y el dolor de cabeza<\/h2>\n\n\n\n<p><strong>Los estudios de investigaci\u00f3n actuales nos indican sobre los siguientes efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/migrana\/\">CBD y el dolor de cabeza<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Disminuye la inflamaci\u00f3n<\/li><li>Bloquea la transmisi\u00f3n del dolor<\/li><li>Puede prevenir la liberaci\u00f3n de serotonina de las plaquetas<\/li><li>Reduce los espasmos vasculares<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y el dolor de cabeza:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22265864\/\">Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A2A receptor.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16672367\/\">Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.<\/a> (2006)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-1024x384.png\" alt=\"\" class=\"wp-image-12569\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/ms-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la escler\u00f3sis m\u00faltiple (EM)<\/h2>\n\n\n\n<p><strong>Seg\u00fan las investigaciones realizadas hasta ahora, estos son beneficios del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/esclerosis-multiple\/\">CBD para la EM<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia el dolor nervioso<\/li><li>Disminuye la neuroinflamaci\u00f3n<\/li><li>Disminuye los espasmos musculares<\/li><li>Mejora el control vesical<\/li><li>No permite la migraci\u00f3n de c\u00e9lulas T a los nervios<\/li><li>Resiste el desarrollo de actividad autoinmune<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y la EM:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30886530\/\">Daily Practice Managing Resistant Multiple Sclerosis Spasticity With Delta-9-Tetrahydrocannabinol: Cannabidiol Oromucosal Spray: A Systematic Review of Observational Studies<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30123217\/\">Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24525548\/\">Nabiximols (THC\/CBD Oromucosal Spray, Sativex\u00ae) in Clinical Practice \u2013 Results of a Multicenter, Non-Interventional Study (MOVE 2) in Patients with Multiple Sclerosis Spasticity.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23180178\/\">A Double-blind, Randomized, Placebo-controlled, Parallel-group Study of THC\/CBD Oromucosal Spray in Combination With the Existing Treatment Regimen, in the Relief of Central Neuropathic Pain in Patients With Multiple Sclerosis<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23851307\/\">Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23851307\/\">Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22973422\/\">Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21878454\/\">A placebo-controlled, parallel-group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex\u00ae(nabiximols).<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21449980\/\">Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis\u2010like disease in C57BL\/6 mice.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20558502\/\">Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19183777\/\">Cannabinoids in the management of spasticity associated with multiple sclerosis.<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18035205\/\">Oromucosal Delta9-tetrahydrocannabinol\/cannabidiol for Neuropathic Pain Associated With Multiple Sclerosis: an Uncontrolled, Open-label, 2-year Extension Trial<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17257464\/\">Meta-analysis of Cannabis Based Treatments for Neuropathic and Multiple Sclerosis-related Pain<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17891167\/\">Cannabinoid control of neuroinflammation related to multiple sclerosis.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16553576\/\">Sativex\u00ae: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15327041\/\">An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11854768\/\">he cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.<\/a> (2001)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9252798\/\">The perceived effects of smoked cannabis on patients with multiple sclerosis.<\/a> (1997)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-1024x384.png\" alt=\"\" class=\"wp-image-12568\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/nausea-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la n\u00e1usea<\/h2>\n\n\n\n<p><strong>Las investigaciones han encontrado los siguientes beneficios del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/nausea\/\">CBD para las n\u00e1useas<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia la inflamaci\u00f3n<\/li><li>Incrementa los niveles de anandamida en el bulbo raqu\u00eddeo<\/li><li>Relaja los calambres musculares y el dolor<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y la n\u00e1usea:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27438607\/\">Effect of Combined Oral Doses of \u0394(9)-tetrahydrocannabinol (THC) and Cannabidiolic Acid (CBDA) on Acute and Anticipatory Nausea in Rat Models<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23121618\/\">Cannabidiolic Acid Prevents Vomiting in Suncus Murinus and Nausea-induced Behaviour in Rats by Enhancing 5-HT1A Receptor Activation<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24012649\/\">Suppression of Lithium Chloride-induced Conditioned Gaping (a Model of Nausea-induced Behaviour) in Rats (using the Taste Reactivity Test) With Metoclopramide Is Enhanced by Cannabidiolic Acid<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21827451\/\">Cannabidiol, a Non-psychotropic Component of Cannabis, Attenuates Vomiting and Nausea-like Behaviour Via Indirect Agonism of 5-HT(1A) Somatodendritic Autoreceptors in the Dorsal Raphe Nucleus<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21243485\/\">Interaction Between Non-psychotropic Cannabinoids in Marihuana: Effect of Cannabigerol (CBG) on the Anti-nausea or Anti-emetic Effects of Cannabidiol (CBD) in Rats and Shrews<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816298\/\">The Effects of Cannabidiol and Tetrahydrocannabinol on Motion-induced Emesis in Suncus Murinus<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11973447\/\">Cannabidiol, a Non-psychoactive Component of Cannabis and Its Synthetic Dimethylheptyl Homolog Suppress Nausea in an Experimental Model With Rats<\/a> (2002)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-1024x384.png\" alt=\"\" class=\"wp-image-12567\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/pain-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y el dolor<\/h2>\n\n\n\n<p><strong>Seg\u00fan las investigaciones realizadas, estos son algunos de los efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/dolor\/\">CBD sobre el dolor<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Activa los receptores de dolor en la m\u00e9dula espinal y el cerebro<\/li><li>Alivia los efectos secundarios comunes del dolor<\/li><li>Apoya la salud de las c\u00e9lulas nerviosas<\/li><li>Disminuye la inflamaci\u00f3n<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y el dolor:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33238607\/\">Cannabidiol for pain treatment: focus on pharmacology and mechanism of action.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30938373\/\">Cannabidiol as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30624194\/\">Cannabidiol in anxiety and sleep: a large case series.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30571957\/\">Effects of cannabidiol in males and females in two different rat models of depression.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30157131\/\">Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31711352\/\">Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30152161\/\">Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29388063\/\">Medical cannabis for neuropathic pain.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29579828\/\">Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29797104\/\">Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28885454\/\">Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28548225\/\">Single and combined effects of \u03949\u2010tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy\u2010induced neuropathic pain.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27000108\/\">Neurophysiologic correlates of headache pain in subjects with major depressive disorder.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28445853\/\">Cannabidiol \u2013 Delta9-Tetrahydrocannabinol Interactions on Acute Pain and Locomotor Activity<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28680401\/\">Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28349233\/\">Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn\u2019s Disease, a Randomized Controlled Trial.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28445853\/\">Cannabidiol-\u03949-tetrahydrocannabinol interactions on acute pain and locomotor activity.<\/a> (2017)<\/li><li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ejp.818\">Transdermal cannabidiol reduces inflammation and pain\u2010related behaviours in a rat model of arthritis.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26517407\/\">Transdermal cannabidiol reduces inflammation and pain\u2010related behaviors in a rat model of arthritis.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24420962\/\">A double\u2010blind, randomized, placebo\u2010controlled, parallel group study of THC\/CBD spray in peripheral neuropathic pain treatment.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23180178\/\">A Double-blind, Randomized, Placebo-controlled, Parallel-group Study of THC\/CBD Oromucosal Spray in Combination With the Existing Treatment Regimen, in the Relief of Central Neuropathic Pain in Patients With Multiple Sclerosis<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23141881\/\">An Open-label Extension Study to Investigate the Long-term Safety and Tolerability of THC\/CBD Oromucosal Spray and Oromucosal Thc Spray in Patients With Terminal Cancer-related Pain Refractory to Strong Opioid Analgesics<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19896326\/\">Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19318283\/\">Antinociceptive effect of the cannabinoid agonist, WIN 55,212\u20102, in the orofacial and temporomandibular formalin tests.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19220500\/\">Cluster attacks responsive to recreational cannabis and dronabinol.<\/a> (2009)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17997224\/\">Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17712817\/\">Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex\u00ae, a cannabis\u2010based medicine.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18035205\/\">Oromucosal Delta9-tetrahydrocannabinol\/cannabidiol for Neuropathic Pain Associated With Multiple Sclerosis: an Uncontrolled, Open-label, 2-year Extension Trial<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17157290\/\">The Non-psychoactive Cannabis Constituent Cannabidiol Is an Orally Effective Therapeutic Agent in Rat Chronic Inflammatory and Neuropathic Pain<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17257464\/\">Meta-analysis of Cannabis Based Treatments for Neuropathic and Multiple Sclerosis-related Pain<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17157290\/\">The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17712817\/\">Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of sativex\u03c1, a cannabis-based medicine.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17712817\/\">Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of sativex, a cannabis-based medicine<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16489449\/\">Cannabidiol is an allosteric modulator at mu-and delta-opioid receptors.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16553576\/\">Sativex\u00ae: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15313881\/\">Vanilloid TRPV1 Receptor Mediates The Antihyperalgesic Effect Of The Nonpsychoactive Cannabinoid, Cannabidiol, In A Rat Model Of Acute Inflammation<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14644587\/\">Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.<\/a> (2003)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11854768\/\">he cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.<\/a> (2001)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-1024x384.png\" alt=\"\" class=\"wp-image-12566\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/sleep-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y el sue\u00f1o<\/h2>\n\n\n\n<p><strong>Esto es lo que dice la investigaci\u00f3n sobre los <a href=\"https:\/\/dailycbd.com\/es\/condicion\/trastornos-del-sueno\/\">efectos del CBD en el sue\u00f1o<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia las causas comunes de insomnio<\/li><li>Disminuye las pesadillas<\/li><li>Regula el ciclo y los patrones del sue\u00f1o<\/li><li>Sus efectos sedantes promueven la conciliaci\u00f3n r\u00e1pida del sue\u00f1o<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y el sue\u00f1o:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30014038\/\">A Cross-Sectional Study of Cannabidiol Users.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29674967\/\">No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24845114\/\">Cannabidiol can improve complex sleep\u2010related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson\u2019s disease patients: a case series.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15118485\/\">Effect of \u0394-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults.<\/a> (2004)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-1024x384.png\" alt=\"\" class=\"wp-image-12565\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Investigaciones acerca del CBD y la p\u00e9rdida de peso<\/h2>\n\n\n\n<p><strong>Se han reportado los siguientes efectos del <a href=\"https:\/\/dailycbd.com\/es\/condicion\/obesidad\/\">CBD para la p\u00e9rdida de peso<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alivia el estr\u00e9s y la ansiedad<\/li><li>Alivia la inflamaci\u00f3n cr\u00f3nica asociada a la obesidad<\/li><li>Alivia los des\u00f3rdenes digestivos y la inflamaci\u00f3n<\/li><li>Apoya la funci\u00f3n hormonal \u00f3ptima<\/li><li>Disminuye el apetito para mejorar los h\u00e1bitos alimenticios<\/li><li>Disminuye la resistencia a la insulina<\/li><li>Mejora la funci\u00f3n mitocondrial (la parte del metabolismo que convierte los az\u00facares y la grasa en energ\u00eda)<\/li><\/ul>\n\n\n\n<p><strong>Lista de estudios de investigaci\u00f3n acerca del CBD y la p\u00e9rdida de peso:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22421529\/\">Cannabis exposure associated with weight reduction and \u03b2-cell protection in an obese rat model.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22133305\/\">A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20428110\/\">Cannabidiol Attenuates the Appetitive Effects of \u03949-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16148436\/\">Endocannabinoids in the regulation of appetite and body weight<\/a> (2005)<\/li><\/ol>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"691\" height=\"361\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin.png\" alt=\"\" class=\"wp-image-12361\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin.png 691w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-300x157.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-180x94.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-283x148.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-54x28.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-330x172.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-420x219.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-74x39.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/04\/young-guy-thinkin-57x30.png 57w\" sizes=\"(max-width: 691px) 100vw, 691px\" \/><\/figure><\/div>\n\n\n\n<h2><a><\/a>Porqu\u00e9 la investigaci\u00f3n del CBD es tan importante<\/h2>\n\n\n\n<p>Desde que se elimin\u00f3 la prohibici\u00f3n del cannabis en el mundo occidental, ha habido gran confusi\u00f3n sobre c\u00f3mo regular el CBD y otros productos a base de cannabis.<\/p>\n\n\n\n<p>Las compa\u00f1\u00edas farmac\u00e9uticas est\u00e1n compitiendo para crear medicamentos de prescripci\u00f3n basados en cannabinoides, como <a href=\"https:\/\/www.epidiolex.com\/\">Epidiolex<\/a> o <a href=\"https:\/\/www.gwpharm.com\/healthcare-professionals\/sativex\">Sativex<\/a>.<\/p>\n\n\n\n<p>Por el lado de la oferta, los fabricantes de extractos bot\u00e1nicos est\u00e1n ansiosos por satisfacer las crecientes demandas del mercado, pero al mismo tiempo, deben navegar con cuidado en un entorno regulatorio incierto.<\/p>\n\n\n\n<p><strong>La convergencia de estos conflictos de intereses es una receta para la creaci\u00f3n problemas y resalta algunas \u00e1reas importantes de preocupaci\u00f3n:<\/strong><\/p>\n\n\n\n<ul><li>\u00bfQu\u00e9 sabemos acerca de la seguridad del CBD a corto y largo plazo?<\/li><li>\u00bfQu\u00e9 condiciones de salud pueden ser tratadas con CBD?<\/li><li>\u00bfQu\u00e9 condiciones de salud pueden empeorar con CBD?<\/li><li>\u00bfC\u00f3mo interact\u00faa el CBD con los medicamentos de prescripci\u00f3n m\u00e9dica?<\/li><\/ul>\n\n\n\n<h2><a><\/a>Los cinco tipos de investigaci\u00f3n del CBD<\/h2>\n\n\n\n<p>Conforme la industria del CBD evoluciona, existe una enorme cantidad de preguntas cient\u00edficas que buscan respuesta.<\/p>\n\n\n\n<p>La respuesta a estas preguntas se basa en la investigaci\u00f3n cient\u00edfica escrupulosa. A trav\u00e9s de diferentes niveles de investigaci\u00f3n, el CBD puede someterse a los mismos est\u00e1ndares estrictos de seguridad y eficacia que cualquier otro f\u00e1rmaco o extracto bot\u00e1nico.<\/p>\n\n\n\n<p><strong>La investigaci\u00f3n del CBD se divide en cinco categor\u00edas principales:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><strong>Nivel 1: Investigaci\u00f3n B\u00e1sica <\/strong>\u2014 Investigaci\u00f3n de bajo nivel para mapear la estructura y propiedades qu\u00edmicas .<\/li><li><strong>Nivel 2: Estudio <em>In Vitro<\/em><\/strong> (utilizando cultivos celulares) \u2014 Investigaci\u00f3n de bajo nivel; comienza a explorar la toxicidad de una sustancia en c\u00e9lulas y tejidos vivos.<\/li><li><strong>Nivel 3: Estudios <em>In Vivo<\/em><\/strong> (usando organismos vivos reales) \u2014 investigaci\u00f3n de alto nivel que involucra seres vivos no humanos.<\/li><li><strong>Nivel 4: Ensayos Cl\u00ednicos <\/strong>\u2014 realizados en humanos en 4 etapas diferentes (I, II, III y IV).<\/li><li><strong>Nivel 5: Meta-an\u00e1lisis <\/strong>\u2014 una revisi\u00f3n de la investigaci\u00f3n cl\u00ednica y precl\u00ednica publicada; proporciona el mayor nivel de evidencia posible al agrupar los datos de estudios similares.<\/li><\/ol>\n\n\n\n<p><strong>Entonces, \u00bfc\u00f3mo funciona el proceso cient\u00edfico y cu\u00e1les son los m\u00e9todos y etapas de investigaci\u00f3n que finalmente nos dir\u00e1n todo lo que necesitamos saber sobre los beneficios y riesgos del CBD?<\/strong><\/p>\n\n\n\n<p>Revisemos m\u00e1s de cerca los diferentes niveles de investigaci\u00f3n cient\u00edfica para estudiar el CBD.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-1024x384.png\" alt=\"\" class=\"wp-image-12564\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-2.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3><a><\/a><strong>Nivel 1: Investigaci\u00f3n b\u00e1sica \u2014 \u00bfEl CBD es seguro?<\/strong><\/h3>\n\n\n\n<p>Se considera que el CBD es seguro y no t\u00f3xico, lo cual es genial. Pero, \u00bfel CBD est\u00e1 completamente libre de cualquier <a href=\"https:\/\/dailycbd.com\/es\/efectos-secundarios\/\">efecto adverso<\/a>?<\/p>\n\n\n\n<p>Esto es lo que los estudios de investigaci\u00f3n b\u00e1sica est\u00e1n dise\u00f1ados para explorar. En lugar de observar los beneficios espec\u00edficos de un compuesto, eval\u00faan qu\u00e9 cantidad del compuesto se necesita para producir efectos t\u00f3xicos en el cuerpo y exploran la composici\u00f3n qu\u00edmica del CBD y otros extractos de cannabis.<\/p>\n\n\n\n<p>Un m\u00e9todo com\u00fan para evaluar la toxicidad es administrar dosis progresivamente de un compuesto (como el CBD) a ratas hasta que muera el 50 % de la poblaci\u00f3n de la muestra. Esto nos da la <a href=\"https:\/\/simple.wikipedia.org\/wiki\/LD50\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">LD50<\/a> de un compuesto (Dosis letal para el 50% de la poblaci\u00f3n).<\/p>\n\n\n\n<p>Se realiza una observaci\u00f3n detallada de c\u00f3mo mueren las ratas, lo que nos da una pista acerca de los efectos adversos t\u00f3xicos que tiene el compuesto.<\/p>\n\n\n\n<p>En las primeras fases de la investigaci\u00f3n b\u00e1sica se determinan las <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19568374\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">propiedades estructurales, moleculares y qu\u00edmicas de una sustancia<\/a>. Esta investigaci\u00f3n preliminar nos dice que el CBD es soluble en grasa pero no en agua y que su f\u00f3rmula molecular es <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/#query=C21H30O2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">C21H30O2<\/a>.<\/p>\n\n\n\n<p>Es gracias a esta investigaci\u00f3n que sabemos que el CBD se ve as\u00ed:<\/p>\n\n\n\n<h4><strong>Ejemplos de los estudios de propiedades estructurales de CBD<\/strong><\/h4>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-1024x683.png\" alt=\"\" class=\"wp-image-12579\" width=\"512\" height=\"342\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-1024x683.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-300x200.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-768x512.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-180x120.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-283x189.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-54x36.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-330x220.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-420x280.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-74x49.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule-45x30.png 45w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/cbd-molecule.png 1200w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/figure><\/div>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Tema de estudio<\/strong><strong><\/strong><\/td><td><strong>Autores<\/strong><strong><\/strong><\/td><td><strong>NIvel de estudio<\/strong><strong><\/strong><\/td><\/tr><tr><td>La estructura del cannabidiol<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/5879214\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Mechoulam et al., 1963<\/a><\/td><td>1<\/td><\/tr><tr><td>Separando cannabinoides<\/td><td>Lerner., 1963<\/td><td>1<\/td><\/tr><tr><td>Identificaci\u00f3n de los subgrupos del CBD<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6715\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Harvey., 1976<\/a><\/td><td>1<\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-1024x384.png\" alt=\"\" class=\"wp-image-12563\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-3.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3><strong>Nivel 2: Estudios <em>in vitro<\/em> \u2014 Pruebas en c\u00e9lulas vivas<\/strong><\/h3>\n\n\n\n<p>Una vez que se miden y catalogan las propiedades estructurales y qu\u00edmicas del CBD, los investigadores introducen cantidades controladas del compuesto en cultivos de c\u00e9lulas y tejidos.<\/p>\n\n\n\n<p>Los cultivos de tejidos son c\u00e9lulas vivas que se cultivan en tubos de ensayo y placas de Petri (traducido literalmente, <em>in vitro<\/em> significa \u00aben vidrio\u00bb). El objetivo de esta investigaci\u00f3n es comenzar a descubrir c\u00f3mo el CBD interact\u00faa con las c\u00e9lulas vivas utilizando entornos altamente controlados.<\/p>\n\n\n\n<p>El proceso in vitro le permite a los cient\u00edficos crear entornos, utilizando una sola c\u00e9lula o tipo de tejido, en los que se pueden controlar todas las variables.<\/p>\n\n\n\n<p>En esta fase de investigaci\u00f3n, es posible dise\u00f1ar un experimento que pregunte y responda una sola pregunta sobre el CBD, lo que no es posible en un ser humano vivo con muchos sistemas complejos que se comunican e influyen entre s\u00ed en todo momento.<\/p>\n\n\n\n<h4><a><\/a><strong>Ejemplos de estudios de CBD In Vitro<\/strong><\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Tema de estudio<\/strong><strong><\/strong><\/td><td><strong>Autores <\/strong><strong><\/strong><\/td><td><strong>Nivel de estudio<\/strong><strong><\/strong><\/td><\/tr><tr><td>CBD y la enfermedad vascular cerebral<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26497782\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Hind et al., 2016<\/a><\/td><td>2<\/td><\/tr><tr><td>CBD y el s\u00edndrome de intestino irritable<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24238999\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Harvey et al., 2014<\/a><\/td><td>2<\/td><\/tr><tr><td>CBD en c\u00e9lulas Cancer\u00edgenas<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19914218\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Ramer et al., 2010<\/a><\/td><td>2<\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-1024x384.png\" alt=\"\" class=\"wp-image-12562\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-4.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3><strong>Nivel 3: Estudios <em>in vivo<\/em> \u2014 Pruebas en animales vivos<\/strong><\/h3>\n\n\n\n<p>El siguiente nivel de investigaci\u00f3n es la investigaci\u00f3n in vivo, que se lleva a cabo en animales vivos y permite a los cient\u00edficos obtener informaci\u00f3n m\u00e1s precisa sobre la eficacia, seguridad y toxicidad de la sustancia. Mediante el uso de sistemas vivos reales, los investigadores pueden probar c\u00f3mo un compuesto afectar\u00e1 al organismo. Las pruebas in vivo pueden comparar los efectos entre diferentes especies. Por lo general, los mam\u00edferos se eligen para la investigaci\u00f3n m\u00e9dica in vivo ya que su fisiolog\u00eda es muy similar a la nuestra.<\/p>\n\n\n\n<p>Gradualmente, la investigaci\u00f3n ha evolucionado de usar roedores (ratones, ratas, conejos, etc.) a especies m\u00e1s grandes (gatos, perros, primates no-humanos). Esto puede demostrar c\u00f3mo la respuesta cambia de una especie a otra y tambi\u00e9n puede ayudar a los investigadores a reducir una dosis inicial segura cuando llegue el momento de probar en humanos.<\/p>\n\n\n\n<p>Con esta informaci\u00f3n, podemos comenzar a comprender c\u00f3mo es que el CBD entra y viaja en el cuerpo, y cu\u00e1nto CBD puede manejar el cuerpo de manera segura. Esta informaci\u00f3n se utiliza como base para las pr\u00f3ximas etapas de investigaci\u00f3n que analizan m\u00e1s de cerca la interacci\u00f3n real que tiene el CBD en el cuerpo humano.<\/p>\n\n\n\n<p><strong>La investigaci\u00f3n In vivo tambi\u00e9n determina:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><strong>C\u00f3mo viaja el CBD a trav\u00e9s del cuerpo<\/strong> \u2014 qu\u00e9 tan r\u00e1pida y eficiente es la absorci\u00f3n hacia el torrente sangu\u00edneo<\/li><li><strong>C\u00f3mo se metaboliza el CBD<\/strong> \u2014 ya sea que se haga en los ri\u00f1ones, el h\u00edgado o en cualquier otra parte del cuerpo<\/li><li><strong>Qu\u00e9 tan seguro o t\u00f3xico es el CBD y sus metabolitos<\/strong> \u2014 algunas veces un compuesto se considera seguro en la investigaci\u00f3n <em>in vitro<\/em> pero muestra efectos t\u00f3xicos cuando se le administra a animales vivos. Por ejemplo, actualmente no hay un LD50 conocido de CBD para humanos; sin embargo, un <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22129319\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">estudio del 2011 encontr\u00f3 que las dosis de 200 \u2013 300 mg\/kg<\/a> son letales en algunos monos rhesus.<\/li><li><strong>C\u00f3mo se excreta el compuesto del cuerpo<\/strong> \u2014 los compuestos pueden salir del cuerpo a trav\u00e9s de la orina, las heces o incluso a trav\u00e9s de la piel.<\/li><li><strong>Los efectos del CBD con ciertas condiciones m\u00e9dicas o s\u00edntomas <\/strong>\u2014 usando animales con problemas de salud, podemos probar el CBD para ver si mejora la condici\u00f3n o la empeora.<\/li><\/ol>\n\n\n\n<p>Una potencial limitaci\u00f3n de la investigaci\u00f3n <em>in vivo<\/em> sobre CBD es que cada especie contiene diferentes recuentos de receptores. A pesar de que todos los mam\u00edferos tienen un <a href=\"https:\/\/dailycbd.com\/es\/sistema-endocannabinoide\/\">sistema endocannabinoide<\/a>, las densidades y distribuciones de los receptores de endocannabinoides pueden variar mucho de una especie a otra \u2014 cambiando los efectos del CBD.<\/p>\n\n\n\n<p>Por ejemplo, las ratas y monos rhesus tienen <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2308954\">una mayor densidad de receptores que los humanos<\/a> en algunas partes de su cerebro y menor densidad en otras partes. Esto hace dif\u00edcil deducir c\u00f3mo el CBD va a actuar en el humano en comparaci\u00f3n con la experimentaci\u00f3n animal.<\/p>\n\n\n\n<p>Actualmente, la FDA y las agencias reguladoras asociadas le est\u00e1n solicitando a los investigadores proveer los datos para <a href=\"https:\/\/www.uab.edu\/medicine\/adda\/images\/131205%20Tox%20Animal%20Models.pdf.\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">sustentar su elecci\u00f3n de especie animal<\/a> para sus estudios. Pero, incluso con estas precauciones, es importante tener en cuenta que los medicamentos que resultan seguros y efectivos en las pruebas con animales pueden tener diferentes efectos en los humanos.<\/p>\n\n\n\n<h4><a><\/a><strong>Ejemplos de investigaci\u00f3n <em>in vivo<\/em> de CBD<\/strong><\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Tema de estudio<\/strong><strong><\/strong><\/td><td><strong>Autores<\/strong><strong><\/strong><\/td><td><strong>Nivel de estudio<\/strong><strong><\/strong><\/td><\/tr><tr><td>CBD para la curaci\u00f3n de heridas<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30088305\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Klein et al., 2018<\/a><\/td><td>3<\/td><\/tr><tr><td>CBD&nbsp; para el miedo y ansiedad<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27296152\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Norris et al., 2016<\/a><\/td><td>3<\/td><\/tr><tr><td>CBD para epilepsia<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19906779\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Jones et al., 2010<\/a><\/td><td>3<\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-1024x384.png\" alt=\"\" class=\"wp-image-12561\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/weightloss-header-5.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3><strong>Nivel 4: Ensayos cl\u00ednicos \u2014 Pruebas en humanos<\/strong><\/h3>\n\n\n\n<p>Una vez que se hayan realizado suficientes investigaciones <em>in vitro<\/em> e <em>in vivo<\/em> para establecer que el CBD podr\u00eda ser razonablemente efectivo y seguro para un prop\u00f3sito particular, pueden comenzar los estudios cl\u00ednicos, es decir, experimentos en voluntarios humanos.<\/p>\n\n\n\n<p><strong>La investigaci\u00f3n cl\u00ednica se considera el nivel m\u00e1s alto de investigaci\u00f3n experimental porque se realiza directamente en humanos.<\/strong> Estos estudios se pueden utilizar para confirmar la farmacocin\u00e9tica de los estudios in vivo y probar si los beneficios en animales de laboratorio se pueden replicar en humanos.<\/p>\n\n\n\n<p><strong>Los ensayos cl\u00ednicos se pueden utilizar para evaluar lo siguiente:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li>El camino que sigue el CBD a trav\u00e9s del cuerpo, desde su absorci\u00f3n, hasta su distribuci\u00f3n y eliminaci\u00f3n.<\/li><li>Los efectos cl\u00ednicos del CBD (es decir, sus beneficios para la salud) as\u00ed como la ausencia o presencia de efectos secundarios.<\/li><li>La dosis \u00f3ptima necesaria para que el CBD se use de manera efectiva en humanos.<\/li><\/ol>\n\n\n\n<p>La calidad de los ensayos cl\u00ednicos puede variar ampliamente, y hay algunos elementos clave que se deben considerar al evaluar la calidad de un ensayo en particular.<\/p>\n\n\n\n<h4><a><\/a><strong>Control de placebo<\/strong><\/h4>\n\n\n\n<p>Un control de placebo es un componente cr\u00edtico de un ensayo cl\u00ednico para garantizar que los resultados del estudio no hayan sido causados \u200b\u200bpor las expectativas de los participantes. Para aplicar un control de placebo, se administra un tratamiento simulado a un grupo (un compuesto inactivo que parece CBD pero no lo es).<\/p>\n\n\n\n<p>Este procedimiento est\u00e1 dise\u00f1ado para eliminar el efecto placebo, donde los s\u00edntomas pueden mejorar si un paciente <em>cree<\/em> que le estaban administrando un medicamento, incluso si no hab\u00eda compuestos activos en el tratamiento. El efecto placebo ocurre en aproximadamente el <a href=\"https:\/\/people.umass.edu\/curtis\/academics\/researchtoolbox\/pdfs\/Placebos_Brody.pdf\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">40% de los participantes del estudio<\/a>.<\/p>\n\n\n\n<h4><a><\/a><strong>Aleatorizaci\u00f3n<\/strong><\/h4>\n\n\n\n<p>Para asegurarse de que no haya patrones en el grupo de tratamiento o en los grupos de control con placebo que puedan afectar los resultados, se utiliza la aleatorizaci\u00f3n estad\u00edstica para separar a los participantes.<\/p>\n\n\n\n<p>Este proceso asegura que los participantes se distribuyan equitativamente a cada brazo del estudio.<\/p>\n\n\n\n<p>La aleatorizaci\u00f3n evita que todos los participantes con una caracter\u00edstica particular, como la edad, el sexo o un factor de riesgo gen\u00e9tico, sean colocados en el mismo grupo. Tambi\u00e9n evita que el sesgo consciente o inconsciente del investigador influya en el experimento, como colocar a todos los participantes con mayor probabilidad de tener una respuesta buena (o mala) en el mismo grupo.<\/p>\n\n\n\n<h4><a><\/a><strong>Ciego<\/strong><\/h4>\n\n\n\n<p>El cegamiento se utiliza para que los participantes del estudio y los investigadores no sepan qu\u00e9 participantes reciben una dosis de CBD o un placebo. Esto elimina el sesgo al no revelar qu\u00e9 tratamiento se est\u00e1 administrando.<\/p>\n\n\n\n<p><strong>Hay dos categor\u00edas de cegamiento:<\/strong><\/p>\n\n\n\n<p><strong>Ciego \u00fanico (ciego simple)<\/strong> \u2014 el participante no es informado de qu\u00e9 tratamiento est\u00e1 recibiendo.<\/p>\n\n\n\n<p>Esto evita que las ideas preconcebidas o las expectativas de los participantes influyan en sus respuestas. El ciego simple puede ayudar a eliminar el efecto placebo.<\/p>\n\n\n\n<p>Adem\u00e1s, muchos estudios se basan en informes subjetivos de los participantes sobre sus s\u00edntomas y experiencia general. El ciego simple elimina estos posibles sesgos. Si creen que est\u00e1n recibiendo el tratamiento, es posible que respondan las preguntas de manera diferente que si supieran que est\u00e1n tomando el placebo. Por lo tanto, es mejor mantener esta parte en secreto hasta que termine el juicio.<\/p>\n\n\n\n<p><strong>Doble ciego<\/strong> \u2014&nbsp; tanto el participante como el investigador no saben qu\u00e9 tratamiento se est\u00e1 administrando a qu\u00e9 participante. Esto evita que el investigador, consciente o inconscientemente, se comporte de manera diferente hacia los participantes de manera que pueda influir en los resultados del estudio.<\/p>\n\n\n\n<p>Los mejores ensayos cl\u00ednicos utilizan el doble ciego en su modelo de investigaci\u00f3n.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"546\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-1024x546.png\" alt=\"\" class=\"wp-image-12583\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-1024x546.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-300x160.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-768x410.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-180x96.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-283x151.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-54x29.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-330x176.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-420x224.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-74x39.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion-56x30.png 56w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/niveles-investigacion.png 1500w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4><a><\/a><strong>Diferentes niveles de ensayos cl\u00ednicos<\/strong><\/h4>\n\n\n\n<h5><a><\/a><strong>A) Ensayos cl\u00ednicos de fase I<\/strong><\/h5>\n\n\n\n<p>Los ensayos de fase I son los primeros estudios en los que se administra un medicamento a un peque\u00f1o grupo de personas (hasta 80). En esta fase, se determina la mejor v\u00eda de administraci\u00f3n, es decir, por v\u00eda oral, inhalada, t\u00f3pica, inyectada en el torrente sangu\u00edneo, etc., as\u00ed como los niveles de dosificaci\u00f3n y la frecuencia ideales.<\/p>\n\n\n\n<p>Si este estudio resulta seguro y muestra buenos resultados, el estudio puede pasar a la fase II.<\/p>\n\n\n\n<h5><a><\/a><strong>B) Ensayos cl\u00ednicos de fase II<\/strong><\/h5>\n\n\n\n<p>Los ensayos cl\u00ednicos de fase II obtienen m\u00e1s informaci\u00f3n de seguridad y comienzan a recopilar datos sobre la eficacia. Estos estudios involucran a un mayor n\u00famero de participantes, generalmente entre 100 y 300.<\/p>\n\n\n\n<h5><a><\/a><strong>C) Ensayos cl\u00ednicos de fase III<\/strong><\/h5>\n\n\n\n<p>Los ensayos cl\u00ednicos de fase III comparan el nuevo f\u00e1rmaco con un f\u00e1rmaco que se usa com\u00fanmente como tratamiento est\u00e1ndar para una afecci\u00f3n en particular. Estos estudios utilizan un gran n\u00famero de participantes (de 300 a 3000 o m\u00e1s).<\/p>\n\n\n\n<p>Una vez que la FDA aprueba un medicamento, el fabricante puede elegir llevar a cabo la cuarta fase de los ensayos, pero tambi\u00e9n o las agencias reguladoras pueden exigirle hacerlo.<\/p>\n\n\n\n<h5><a><\/a><strong>D) Ensayos cl\u00ednicos de fase IV<\/strong><\/h5>\n\n\n\n<p>Los ensayos cl\u00ednicos de fase IV determinan los efectos secundarios a largo plazo y la relaci\u00f3n riesgo-beneficio para alguien que pueda necesitar usar el medicamento durante un largo per\u00edodo de tiempo. Estos estudios utilizan la mayor cantidad de personas, y los participantes pueden llegar a ser miles. Tambi\u00e9n tienden a cubrir varios meses o incluso a\u00f1os para recopilar datos de salud a largo plazo.<\/p>\n\n\n\n<h5><a><\/a><strong>E) Investigaci\u00f3n epidemiol\u00f3gica<\/strong><\/h5>\n\n\n\n<p>Una vez que un medicamento basado en CBD ha sido aprobado por la FDA, puede incluirse en la investigaci\u00f3n epidemiol\u00f3gica. La epidemiolog\u00eda busca comprender la frecuencia y los patrones de distribuci\u00f3n de una enfermedad o condici\u00f3n de salud.<\/p>\n\n\n\n<p>Parte de la epidemiolog\u00eda implica estudiar los efectos de las intervenciones, que pueden incluir la eliminaci\u00f3n de la exposici\u00f3n a toxinas y contaminantes ambientales, el cambio de h\u00e1bitos de vida que predisponen a las personas a desarrollar ciertas afecciones, y tambi\u00e9n los efectos de las drogas u otras sustancias, como el CBD, en la <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19547627\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">distribuci\u00f3n de una enfermedad en particular dentro de una poblaci\u00f3n<\/a>.<\/p>\n\n\n\n<p>Para comprender mejor el valor de los estudios cl\u00ednicos sobre el CBD, el tipo de informaci\u00f3n que brindan y sus inconvenientes, echemos un vistazo m\u00e1s de cerca a algunos ejemplos.<\/p>\n\n\n\n<h4><a><\/a><strong>Ejemplos de ensayos cl\u00ednicos que involucran CBD<\/strong><\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Temas de estudio<\/strong><strong><\/strong><\/td><td><strong>Autores<\/strong><strong><\/strong><\/td><td><strong>Nivel de estudio<\/strong><strong><\/strong><\/td><\/tr><tr><td>CBD para la enfermedad de Crohn<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28349233\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Naftali et al., 2017<\/a><\/td><td>4<\/td><\/tr><tr><td>CBD para la ansiedad y el insomnio<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30624194\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Shannon et al., 2019<\/a><\/td><td>4<\/td><\/tr><tr><td>CBD para las personas sanas<\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30374683\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Taylor et al., 2018<\/a><\/td><td>4<\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-1024x384.png\" alt=\"\" class=\"wp-image-12560\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-1024x384.png 1024w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-300x113.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-768x288.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-1536x576.png 1536w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-180x68.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-283x106.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-54x20.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-330x124.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-420x158.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-74x28.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header-80x30.png 80w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2022\/07\/meta-analysis-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3><strong>Nivel 5: Meta-an\u00e1lisis \u2014 Comparando datos de m\u00faltiples estudios<\/strong><\/h3>\n\n\n\n<p>Un meta-an\u00e1lisis es un tipo de revisi\u00f3n sistem\u00e1tica, un estudio de estudios, en el que los datos de m\u00faltiples estudios sobre un aspecto particular del CBD se recopilan y eval\u00faan juntos. Un metan\u00e1lisis puede incluir estudios precl\u00ednicos o cl\u00ednicos.<\/p>\n\n\n\n<p>Cuanto mayor sea el nivel de los estudios utilizados en el meta-an\u00e1lisis, m\u00e1s fuerte ser\u00e1 la evidencia para un efecto particular. Por ejemplo, un meta-an\u00e1lisis que incluye ensayos aleatorios en humanos, doble ciego, controlados con placebo producir\u00e1 pruebas m\u00e1s s\u00f3lidas que un metan\u00e1lisis de estudios en animales.<\/p>\n\n\n\n<h4><a><\/a><strong>Ejemplos de meta-an\u00e1lisis que involucran CBD<\/strong><\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Tema de estudio<\/strong><strong><\/strong><\/td><td><strong>Autores<\/strong><strong><\/strong><\/td><td><strong>Nivel de estudio<\/strong><strong><\/strong><\/td><\/tr><tr><td><strong>CBD para la epilepsia<\/strong><strong><\/strong><\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31731110\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">de Carvalho Reis et al., 2019<\/a><\/td><td>5<\/td><\/tr><tr><td><strong>CBD para la enfermedad vascular cerebral<\/strong><strong><\/strong><\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25492113\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">England et al., 2015<\/a><\/td><td>5<\/td><\/tr><tr><td><strong>Efectos del CBD en el sistema circulatorio<\/strong><strong><\/strong><\/td><td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20558502\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Wade et al., 2010<\/a><\/td><td>5<\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"851\" height=\"293\" src=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4.png\" alt=\"\" class=\"wp-image-11045\" srcset=\"https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4.png 851w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-300x103.png 300w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-768x264.png 768w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-180x62.png 180w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-283x97.png 283w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-54x19.png 54w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-330x114.png 330w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-420x145.png 420w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-74x25.png 74w, https:\/\/dailycbd.com\/es\/wp-content\/uploads\/sites\/9\/2021\/11\/marihuana-gummies-4-87x30.png 87w\" sizes=\"(max-width: 851px) 100vw, 851px\" \/><\/figure>\n\n\n\n<h2><a><\/a>Puntos clave: \u00bfcu\u00e1l es el futuro de la investigaci\u00f3n sobre el CBD?<\/h2>\n\n\n\n<p>La investigaci\u00f3n sobre el cannabis estuvo restringida durante casi 80 a\u00f1os debido a la prohibici\u00f3n de la planta. Ahora los cient\u00edficos est\u00e1n trabajando arduamente para llenar los vac\u00edos, pero al mismo tiempo el panorama regulatorio es incierto y la informaci\u00f3n disponible para los consumidores de CBD puede ser confusa.<\/p>\n\n\n\n<p>Los cient\u00edficos est\u00e1n utilizando diferentes modelos de investigaci\u00f3n para responder algunas de las preguntas m\u00e1s importantes que tenemos sobre el uso de CBD:<\/p>\n\n\n\n<ul><li>\u00bfQu\u00e9 tan seguro es el CBD?<\/li><li>\u00bfC\u00f3mo se puede usar el CBD para aliviar alguna condici\u00f3n?<\/li><li>\u00bfPuede el CBD empeorar alguna condici\u00f3n?<\/li><li><a href=\"https:\/\/dailycbd.com\/es\/interacciones-medicamentosas\/\">\u00bfC\u00f3mo interact\u00faa el CBD con otros medicamentos?<\/a><\/li><\/ul>\n\n\n\n<p>Conocer algunos de los c\u00f3mo y por qu\u00e9 de la investigaci\u00f3n cient\u00edfica puede ayudarlo a interpretar las \u00faltimas noticias sobre el CBD para que pueda ser un consumidor informado.<\/p>\n\n\n\n<p><strong>Los estudios m\u00e9dicos cient\u00edficos se pueden dividir en cinco categor\u00edas diferentes:<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li><strong>Nivel 1: Investigaci\u00f3n b\u00e1sica <\/strong>\u2014 investigaci\u00f3n temprana para evaluar la estructura molecular y las propiedades qu\u00edmicas.<\/li><li><strong>Nivel 2: Investigaci\u00f3n <em>in vitro<\/em> <\/strong>\u2014 investigaci\u00f3n altamente controlada para evaluar los efectos beneficiosos y t\u00f3xicos del CBD en c\u00e9lulas y tejidos aislados cultivados en tubos de ensayo.<\/li><li><strong>Nivel 3: Investigaci\u00f3n <em>in vivo<\/em><\/strong> \u2014 pruebas reales de CBD en seres animales vivos para evaluar la seguridad y la eficacia.<\/li><li><strong>Nivel 4: Ensayos cl\u00ednicos<\/strong> \u2014 pruebas en humanos para evaluar la dosis, la eficacia y la comparaci\u00f3n de CBD con otros compuestos.<\/li><li><strong>Nivel 5: Meta-an\u00e1lisis<\/strong> \u2014 an\u00e1lisis continuo de datos de m\u00faltiples estudios similares sobre un perfil de efecto particular.<\/li><\/ol>\n\n\n\n<p>A trav\u00e9s de la investigaci\u00f3n continua, desde la investigaci\u00f3n b\u00e1sica hasta el metan\u00e1lisis a gran escala, podemos buscar una comprensi\u00f3n m\u00e1s profunda de c\u00f3mo funciona el CBD y c\u00f3mo usarlo de manera segura y efectiva para una amplia gama de diferentes s\u00edntomas y problemas de salud.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El CBD (cannabidiol) es uno de los compuestos naturales m\u00e1s investigados en el mundo.<\/p>\n","protected":false},"author":1,"featured_media":12557,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[561,631],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.8 - 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