{"id":21801,"date":"2020-07-07T22:09:25","date_gmt":"2020-07-07T22:09:25","guid":{"rendered":"http:\/\/dailycbd.com\/en\/?p=21801"},"modified":"2022-01-12T19:30:49","modified_gmt":"2022-01-12T19:30:49","slug":"cbg","status":"publish","type":"post","link":"https:\/\/dailycbd.com\/en\/cbg\/","title":{"rendered":"CBG (Cannabigerol): The Cannabis Stem Cell"},"content":{"rendered":"\n<h2>Top 5 CBG Products to Check Out in 2022<\/h2>\n\n\n\n<ol><li><a rel=\"noreferrer noopener nofollow\" href=\"\/en\/go\/industrial-hemp-farms\" target=\"_blank\">Industrial Hemp Farms<\/a> \u2014&nbsp;Jack Frost CBG Hemp Flower<\/li><li><a rel=\"noreferrer noopener nofollow\" href=\"\/en\/go\/cannaflower\" target=\"_blank\">Canna Flower CBD<\/a> \u2014&nbsp;White CBG Flower<\/li><li><a rel=\"noreferrer noopener nofollow\" href=\"\/en\/go\/nordic-oil\" target=\"_blank\">Nordic Oil<\/a> \u2014 CBG Crystals<\/li><li><a rel=\"noreferrer noopener nofollow\" href=\"http:\/\/dailycbd.com\/en\/go\/rare-cannabinoid-co\/cbg-defense\/\" target=\"_blank\">Rare Cannabinoid Co. <\/a>\u2014&nbsp;CBG Defense Tincture<\/li><li><a href=\"\/en\/go\/ihf\/cbg-isolate\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Industrial Hemp Farms<\/a> \u2014&nbsp;CBG Isolate<\/li><\/ol>\n\n\n\n<h2>What is CBG? <\/h2>\n\n\n\n<p><strong>CBG is short for cannabigerol. <\/strong>It\u2019s often referred to as the \u201cstem cell\u201d of <a href=\"http:\/\/dailycbd.com\/en\/cannabinoids\/\">cannabinoids<\/a> because it serves as the precursor molecule for most naturally occurring cannabinoids, including CBD (cannabidiol), <a href=\"http:\/\/dailycbd.com\/en\/thc-oil\/\">delta 9 THC (tetrahydrocannabinol)<\/a>, and <a href=\"http:\/\/dailycbd.com\/en\/cbc\/\">CBC (cannabichromene)<\/a>. <\/p>\n\n\n\n<p>This molecule begins to form in the hemp plant around weeks 3 and 4 of the flowering cycle. By week 6 CBG starts to convert into THC, CBD, or CBC as it\u2019s exposed to UV light. <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1024\" height=\"699\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-1024x699.jpg\" alt=\"\" class=\"wp-image-21807\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-1024x699.jpg 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-300x205.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-768x524.jpg 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-180x123.jpg 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-283x193.jpg 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-54x37.jpg 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-330x225.jpg 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-420x287.jpg 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-74x51.jpg 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway-44x30.jpg 44w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/CBG-pathway.jpg 1835w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Some plants produce a similar molecule, called CBGV which is then converted into <a href=\"http:\/\/dailycbd.com\/en\/cbdv\/\">CBDV<\/a>, <a href=\"http:\/\/dailycbd.com\/en\/thcv\/\">THCV<\/a>, and CBCV. <\/p>\n\n\n\n<p>Cannabigerol is the starting point for many cannabinoids outside of this range as well. Basically, any naturally occurring cannabinoid starts its life as CBG. <\/p>\n\n\n\n<p>CBD analogs made from CBG include CBDP, delta 8 CBD, delta 9 CBD, and delta 10 CBD. <\/p>\n\n\n\n<p>THC analogs include delta 7 THC, <a href=\"http:\/\/dailycbd.com\/en\/delta-8-thc\/\">delta 8 THC<\/a>, <a href=\"http:\/\/dailycbd.com\/en\/thc-oil\/\">delta 9 THC<\/a>, <a href=\"http:\/\/dailycbd.com\/en\/delta-10-thc\/\">delta 10 THC<\/a>, <a href=\"http:\/\/dailycbd.com\/en\/thcp\/\">THCP<\/a>, <a href=\"http:\/\/dailycbd.com\/en\/thcc\/\">THCC<\/a>, <a href=\"http:\/\/dailycbd.com\/en\/hhc\/\">HHC<\/a>, and more. <\/p>\n\n\n\n<h3>How Plant Breeders are Producing High-CBG Hemp Strains<\/h3>\n\n\n\n<p>Some cannabis plants convert most of the CBG into THC (marijuana plants), others convert most of it to CBD (hemp plants). As the plants convert CBG into other cannabinoids, the total levels of CBG begin to drop. By the time it\u2019s ready to harvest the plants, most cannabis contains less than 1% CBG. <\/p>\n\n\n\n<p>Cannabis breeders can play around with the cannabinoid levels in their plants through selective breeding, or more advanced gene-editing techniques. Both methods have the same goal \u2014 to play around with the enzymes responsible for converting CBG to other cannabinoids. <\/p>\n\n\n\n<p>If the breeder wants more CBD, they select strains that have more CBD-converting enzymes. The same goes for both THC and CBC as well. <\/p>\n\n\n\n<p>Some breeders are even creating cannabis strains that knock out all of these enzymes completely \u2014 yielding much higher concentrations of CBG instead. <\/p>\n\n\n\n<p>A simpler method to preserve CBG is to simply\nharvest the plants early (around the 6-week mark of an 8-week flower cycle)\nbefore they\u2019ve had a chance to convert CBG to other cannabinoids. <\/p>\n\n\n\n<p>Hemp plants have more CBD-converting enzymes and very few THC enzymes. <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1024\" height=\"683\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-1024x683.jpg\" alt=\"\" class=\"wp-image-21834\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-1024x683.jpg 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-300x200.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-768x512.jpg 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-1920x1280.jpg 1920w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-180x120.jpg 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-283x189.jpg 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-54x36.jpg 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-330x220.jpg 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-420x280.jpg 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-74x49.jpg 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/hemp-breeding-45x30.jpg 45w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2>What Are the Benefits of CBG? <\/h2>\n\n\n\n<p>Research on the effects of CBG is still early,\nbut there are already a variety of interesting studies involving this novel\ncannabinoid. <\/p>\n\n\n\n<p><strong>Summary: The Benefits of CBG<\/strong><\/p>\n\n\n\n<ul><li>Appetite-stimulant<\/li><li>Anti-anxiety<\/li><li>Anti-cancer<\/li><li>Anti-psychotropic<\/li><li>Anti-glaucoma<\/li><li>Antibacterial<\/li><li>Anti-inflammatory<\/li><\/ul>\n\n\n\n<h3>A) CBG Offers Potent Anti-Anxiety\nEffects<\/h3>\n\n\n\n<p>One of the driving factors behind the rising popularity of CBG products is their effect on anxiety. Some experts suggest CBG is even more reliable for managing anxiety than CBD. <\/p>\n\n\n\n<p>The anti-anxiety effects of CBG rely on its\nability to inhibit the reuptake and destruction of an important\nneurotransmitter known as GABA. Once a neurotransmitter is released, the\nneurons reabsorb it and begin to break it down. By blocking this effect, neurotransmitters\nlike GABA increase in concentration around the neurons \u2014 producing a stronger\nrelaxant effect. <\/p>\n\n\n\n<p>GABA is the primary neuro-inhibitory compound\nin the brain. It\u2019s tasked with controlling excessive electrical activity\ninduced by stress and anxiety. GABA is also important for our parasympathetic\nnervous system \u2014 which is responsible for our \u201crest and digest\u201d response. <\/p>\n\n\n\n<p>Most of the anti-anxiety medications used\ntoday employ this same neurotransmitter \u2014 GABA. They work by reducing the\nreabsorption and destruction (just like CBG) or enhancing the binding activity\nof GABA directly. Drugs like Xanax and other benzodiazepines work through\nmechanisms like this to induce a sense of calmness and relaxation. <\/p>\n\n\n\n<h3>B) CBG Blocks the Psychoactive\nEffects of THC<\/h3>\n\n\n\n<p>CBG itself is completely non-psychoactive.\nThis means that no matter how much you take, it won\u2019t make you feel high. <\/p>\n\n\n\n<p>But it goes even one step further. <\/p>\n\n\n\n<p>CBG not only doesn\u2019t make you high, but it can also negate the psychoactivity of THC \u2014&nbsp;which is the active compound responsible for the high induced when using marijuana. <\/p>\n\n\n\n<p>THC makes us high by activating the CB1 receptors \u2014 which are one of the main <a href=\"http:\/\/dailycbd.com\/en\/endocannabinoid-system\/\">endocannabinoid receptors<\/a> in the central nervous system. <\/p>\n\n\n\n<p>Once activated, the CB1 receptors cause a cascade of neurotransmitter release, including serotonin, norepinephrine, and dopamine. It\u2019s this influx of neurotransmitters \u2014 particularly serotonin \u2014 that causes changes in perception associated with the marijuana high. <\/p>\n\n\n\n<p>THC also activates two specific serotonin\nreceptors directly \u2014&nbsp;known as 5HT1A and 5HT2A. Both receptors are directly\ninvolved with changes in perception, mood, and various other biological\nprocesses (such as heart rate, blood pressure, and body temperature). <\/p>\n\n\n\n<p>CBG has been shown to block many of the psychoactive\neffects of THC by binding and blocking the CB1 receptors as well as the 5HT1A\nserotonin receptors [8]. This explains why marijuana strains that have been\nharvested too early (higher CBG levels) are far less potent than marijuana\nflowers that are allowed to ripen. <\/p>\n\n\n\n<p>Some people are combining CBG extracts, or <a href=\"https:\/\/dailycbd.com\/en\/cbg\/hemp-flower\/\">CBG-rich flowers<\/a> with marijuana to limit the psychoactive side effects. <\/p>\n\n\n\n<h3>C) CBG May Improve Glaucoma <\/h3>\n\n\n\n<p>The endocannabinoid system plays a critical role in the health of the eye. There\u2019s a dense concentration of endocannabinoid receptors within the eye tissue, responsible for maintaining the health of this sensitive organ. This is one of the reasons why cannabis products are so effective for supporting eye conditions like <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/glaucoma\/\">glaucoma<\/a>. <\/p>\n\n\n\n<p>A Polish study published in 2008 clearly demonstrated that CBG was one of the primary powerhouses of cannabis providing a reduction in intraocular pressure associated with glaucoma [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19112869\/\" target=\"_blank\" rel=\"noreferrer noopener\">1<\/a>]. <\/p>\n\n\n\n<p>It\u2019s thought this ability to reduce\nintraocular pressure is a result of the potent vasodilator (blood-vessel\ndilating) effects of CBG. <\/p>\n\n\n\n<p>This effect is important because other studies\nhave shown that CBD itself isn\u2019t an effective treatment for glaucoma\n\u2014&nbsp;forcing patients to use psychoactive cannabis products instead. Many\npeople using cannabis products aren\u2019t interested in getting high and see this\nas a negative. Now, with CBG, patients may be able to get relief from glaucoma\nwithout the psychoactive side effects. <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1024\" height=\"991\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-1024x991.jpg\" alt=\"\" class=\"wp-image-21837\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-1024x991.jpg 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-300x290.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-768x743.jpg 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-180x174.jpg 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-40x40.jpg 40w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-283x274.jpg 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-54x52.jpg 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-330x319.jpg 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-420x407.jpg 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-74x72.jpg 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram-31x30.jpg 31w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/glaucoma-diagram.jpg 1500w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3>D) CBG is a Promising Anti-Cancer\nAgent<\/h3>\n\n\n\n<p>Several cannabinoids have been linked with increased cancer survival rates in the past. While a lot of this research has been focused on THC and CBD, other studies have been going on to investigate some of the novel cannabinoids like CBG as well \u2014 with promising results. <\/p>\n\n\n\n<p>In 2014, a study looked at the anticancer potential of CBG for colon cancer cell lines (carcinoma). The study found that CBG inhibited the growth of colon cancer in mice [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25269802\/\" target=\"_blank\" rel=\"noreferrer noopener\">3<\/a>]. <\/p>\n\n\n\n<p>Researchers in this study suggested that the primary anti-cancer benefit of CBG was a result of its ability to inhibit a receptor in our cells known as TRPM8 (Transient receptor potential cation channel subfamily M). This receptor is commonly referred to as the \u201cmenthol receptor\u201d because it\u2019s used to produce the trigger \u201ccooling\u201d sensation of menthol. <\/p>\n\n\n\n<p>TRPM8 is important because it\u2019s involved in the growth, proliferation, and survival of certain cancer cell lines [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4695882\" target=\"_blank\" rel=\"noreferrer noopener\">4<\/a>]. Blocking this channel is one of the key areas of research for developing new anticancer medications. <\/p>\n\n\n\n<p><strong>Specifically, TRPM8 has been implicated\nin the following cancer types: <\/strong><\/p>\n\n\n\n<ul><li>Adenocarcinoma (breast, colon,\nlung, pancreatic, and prostate cancer)<\/li><li>Lung carcinoma<\/li><li>Melanoma (skin cancer)<\/li><li>Urinary bladder carcinoma<\/li><li>Neuroblastoma<\/li><li>Glioblastoma multiforme (brain\ncancer)<\/li><li>Oral squamous cell carcinoma\n(mouth cancer)<\/li><li>Osteosarcoma (bone cancer)<\/li><\/ul>\n\n\n\n<p>The colon cancer study also suggested CBG had an inhibitory effect on colon cancer through its potent anti-inflammatory effect profile specific to the colon. Studies have shown that chronic inflammation in the colon and the upper digestive tract was linked to the development of colon cancer [<a href=\"https:\/\/www.gastrojournal.org\/article\/S0016-5085(10)00176-9\/fulltext\">5<\/a>]. <\/p>\n\n\n\n<h3>E) CBG Has Antibacterial\nProperties<\/h3>\n\n\n\n<p>There have been several studies looking at the\nantibacterial abilities of cannabis derivatives.<\/p>\n\n\n\n<p>All five of the primary cannabinoids produced by cannabis (THC, CBD, CBG, CBC, and CBN) have shown potent inhibitory effects on drug-resistant strains of staphylococcus bacteria [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18681481\/\" target=\"_blank\" rel=\"noreferrer noopener\">7<\/a>]. <\/p>\n\n\n\n<p>CBG, in particular, was found to work by\nreducing the permeability of the bacterial cell wall \u2014 effectively disrupting\nits ability to obtain nutrients to survive. <\/p>\n\n\n\n<p>CBG essentially causes the bacteria to starve to death. <\/p>\n\n\n\n<p><strong>Related: <\/strong><a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/antibiotic-resistance\/\">Antibiotic Resistance and CBD<\/a>.<\/p>\n\n\n\n<h3>F) CBG is a Potent\nAnti-Inflammatory<\/h3>\n\n\n\n<p>One of the most prominent health benefits of cannabis is its <a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/inflammation\/\">anti-inflammatory effects<\/a>. While a lot of this activity is the result of CBD, other cannabinoids have also been shown to reduce inflammation in other ways. <\/p>\n\n\n\n<p>CBG was recently shown to block a series of separate inflammatory channels in the body that are specific to inflammatory bowel disease in mice [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23415610\/\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>]. <\/p>\n\n\n\n<p>In the study, CBG had an inhibitory effect on\ninflammatory regulators including myeloperoxidase, iNOS expression, IL-1,\nIL-10, and interferon-\u03b3. <\/p>\n\n\n\n<p>CBG also reduced nitric oxide production in\nthe macrophages and increased the production of superoxide dismutase \u2014&nbsp;one\nof the key antioxidants produced by the body to defend against inflammation. <\/p>\n\n\n\n<p>At the end of the study, the colon of the\ninflamed mice was weighed and found to have dramatically reduced in weight \u2014\nwhich indicates a dramatic reduction of inflammation in the colon. <\/p>\n\n\n\n<h3>G) CBG Makes You Hungry<\/h3>\n\n\n\n<p>It\u2019s common knowledge these days that marijuana gives you the munchies. While there\u2019s a lot of humor around this effect in pop culture references, this also has some therapeutic benefits of its own. <\/p>\n\n\n\n<p>People suffering from eating disorders,\ncachexia, or lack of appetite as a side effect of cancer therapies are all\ncommon reasons for using an appetite stimulant. <\/p>\n\n\n\n<p>Studies involving CBD have found this popular cannabinoid not only <a href=\"https:\/\/dailycbd.com\/en\/does-cbd-make-you-hungry\/\">lacks appetite-boosting effects<\/a>, it actually has the opposite effect \u2014&nbsp;reducing our appetite even further. <\/p>\n\n\n\n<p>Recent studies have shown that CBG instead\noffers powerful appetite-stimulating activity. This gives patients looking to\nincrease their food intake another option that doesn\u2019t bring the psychoactive\nside effects of marijuana products. <\/p>\n\n\n\n<p>Animal studies involving CBG found that mice dosed with CBG ate twice as much food as mice not given the cannabinoid [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27503475\/\" target=\"_blank\" rel=\"noreferrer noopener\">9<\/a>]. <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1024\" height=\"654\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-1024x654.jpg\" alt=\"\" class=\"wp-image-21839\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-1024x654.jpg 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-300x192.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-768x490.jpg 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-1920x1226.jpg 1920w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-180x115.jpg 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-283x181.jpg 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-54x34.jpg 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-330x211.jpg 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-420x268.jpg 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-74x47.jpg 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-powder-47x30.jpg 47w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2>CBG vs CBD: Main Similarities\n&amp; Differences<\/h2>\n\n\n\n<p>CBG is the precursor for <a href=\"https:\/\/dailycbd.com\/en\/cbd-ultimate-guide\/\">CBD<\/a>, so it\u2019s no surprise the two have a lot of similarities. <\/p>\n\n\n\n<p>The hemp plant uses an enzyme known as CBDA\nsynthase to alter the structure of CBG and convert it into CBD. During this\nprocess, the structure, and effect profile of the molecule changes.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1024\" height=\"448\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-1024x448.jpg\" alt=\"\" class=\"wp-image-21808\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-1024x448.jpg 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-300x131.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-768x336.jpg 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-180x79.jpg 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-283x124.jpg 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-54x24.jpg 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-330x144.jpg 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-420x184.jpg 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-74x32.jpg 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg-69x30.jpg 69w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/06\/cbg-cbg.jpg 1388w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4>Comparing the Similarities &amp;\nDifferences of CBD &amp; CBG<\/h4>\n\n\n<table class=\"t-main\">\r\n\t<thead>\r\n\t\t<tr>\r\n\t\t\t\t\t\t\t<th><\/th>\r\n\t\t\t\t\t\t\t<th><p style=\"text-align: left\"><strong>CBD (Cannabidiol)<\/strong><\/p>\n<\/th>\r\n\t\t\t\t\t\t\t<th><p style=\"text-align: left\"><strong>CBG (Cannabigerol)<\/strong><\/p>\n<\/th>\r\n\t\t\t\t\t<\/tr>\r\n\t<\/thead>\r\n\r\n\t<tbody>\r\n\t\t\t\t\t<tr>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p><strong>Primary Benefits<\/strong><\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBD (Cannabidiol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<ul>\n<li>Anti-Inflammatory<\/li>\n<li><a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/pain\/\">Analgesic (Pain-Killer)<\/a><\/li>\n<li><a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/anxiety-depression\/\">Anti-Anxiety<\/a><\/li>\n<li><a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/cancer\/\">Anti-Cancer<\/a><\/li>\n<li>Immunomodulator<\/li>\n<li><a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/sleep\/\">Sleep-Supportive<\/a><\/li>\n<\/ul>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBG (Cannabigerol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<ul>\n<li>Anti-Inflammatory<\/li>\n<li>Anti-Glaucoma<\/li>\n<li>Anti-Cancer<\/li>\n<li>Anti-Anxiety<\/li>\n<li>Appetite Stimulant<\/li>\n<li>Antibacterial<\/li>\n<li>Neuroprotective<\/li>\n<\/ul>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t<\/tr>\r\n\t\t\t\t\t<tr>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\"><strong data-rich-text-format-boundary=\"true\">Where it\u2019s Most Abundant<\/strong><\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBD (Cannabidiol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">Ripe Hemp Flowers<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBG (Cannabigerol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">Premature (Early Harvest) Hemp Flowers &amp; Specialty Strains<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t<\/tr>\r\n\t\t\t\t\t<tr>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p><strong data-rich-text-format-boundary=\"true\">Effects on Appetite<\/strong><\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBD (Cannabidiol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">Decreases appetite<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBG (Cannabigerol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">Increases Appetite<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t<\/tr>\r\n\t\t\t\t\t<tr>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p><strong>Effects on Inflammation<\/strong><\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBD (Cannabidiol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">\u2191\u2191\u2191 Anti-Inflammatory Effects \u00a0 <br data-rich-text-line-break=\"true\" \/><br data-rich-text-line-break=\"true\" \/>(TNF-a, NFkB, IFN-\u03b3, IL-4, IL-6, IL-8, IL-12)<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBG (Cannabigerol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">\u2191 Anti-Inflammatory Effects \u00a0 <br data-rich-text-line-break=\"true\" \/><br data-rich-text-line-break=\"true\" \/>(IL-1, IL-10, IFN-\u03b3)<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t<\/tr>\r\n\t\t\t\t\t<tr>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p><strong>Effects on Pain Inhibition \u00a0<\/strong><\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBD (Cannabidiol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">\u2191\u2191\u2191 Very Strong Pain Inhibition<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBG (Cannabigerol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">\u2191 Mild Pain Inhibition<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t<\/tr>\r\n\t\t\t\t\t<tr>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p><strong>Cost per mg<\/strong><\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBD (Cannabidiol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">$$<\/p>\n<p style=\"text-align: left\">$0.05 \u2013 $0.30 per milligram<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBG (Cannabigerol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">$$$<\/p>\n<p style=\"text-align: left\">$0.20 \u2013 $0.40 per milligram<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t<\/tr>\r\n\t\t\t\t\t<tr>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p><strong>Availability<\/strong><\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBD (Cannabidiol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">Widely Available<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t\t\t<td\r\n\t\t\t\t\t\tdata-align=\"top\" data-width=\"normal\"\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\tdata-title=\"CBG (Cannabigerol)\"\r\n\t\t\t\t\t\t\t\t\t\t\t>\r\n\t\t\t\t\t\t<p style=\"text-align: left\">Hard to Find<\/p>\n\t\t\t\t\t<\/td>\r\n\t\t\t\t\t\t\t<\/tr>\r\n\t\t\t<\/tbody>\r\n<\/table>\r\n\n\n\n<h2>Is CBG Legal? <\/h2>\n\n\n\n<p>CBG products are controlled under the same laws as CBD in <a href=\"http:\/\/dailycbd.com\/en\/is-cbd-legal\/\">the United States<\/a> and <a href=\"http:\/\/dailycbd.com\/en\/canada\/\">Canada<\/a>. <\/p>\n\n\n\n<p>The main distinction relies on whether the CBG\nproduct comes from <a href=\"http:\/\/dailycbd.com\/en\/hemp-vs-marijuana\/\">hemp or marijuana plants<\/a>. <\/p>\n\n\n\n<p>As long as CBG products are made from hemp plants (less than 0.3% THC) they\u2019re completely legal to buy and use. In <a href=\"http:\/\/dailycbd.com\/en\/europe\/\">Europe<\/a>, the maximum amount of THC is slightly lower, at 0.2%, and in many parts of <a href=\"http:\/\/dailycbd.com\/en\/south-america\/\">South America<\/a>, this number is higher (1%). Some places mandate 0% THC for CBG or CBD products to remain legal. <\/p>\n\n\n\n<p>For specific information on the legal status of hemp extracts check out our <a href=\"http:\/\/dailycbd.com\/en\/is-cbd-legal\/\">international guide to legal hemp products<\/a>. We provide updated information on CBD, CBG, and hemp laws in countries around the world. <\/p>\n\n\n\n<h2>Where to Buy CBG Products: Best Online\nSources<\/h2>\n\n\n\n<p>If you were to look for CBG products 5 years\nago \u2014 you\u2019d be completely out of luck. There were virtually no CBG products\navailable on the market whatsoever until about mid-2019. <\/p>\n\n\n\n<p>Today, there\u2019s a growing number of reputable CBD companies now offering CBG versions of their products. You can find CBG flower (specially-bred hemp strains that contain high CBG concentrations), CBG tinctures, CBG extracts, and more. <\/p>\n\n\n\n<p>You can pick up some fresh CBG flowers from <a href=\"http:\/\/dailycbd.com\/en\/company\/industrial-hemp-farms\/\">Industrial Hemp Farms<\/a> or CBG isolate from <a href=\"http:\/\/dailycbd.com\/en\/company\/nordic-oil\/\">Nordic Oil<\/a>. <\/p>\n\n\n\n<h2>CBG Spec Sheet: Mechanisms of\nAction for CBG<\/h2>\n\n\n\n<p>For those of you who want to know the specific receptors CBG interacts with, here\u2019s a summary of what the research has found so far:<\/p>\n\n\n\n<ol><li>TRPM8 antagonist [4]<\/li><li>TRPA1, TRPV1 and TRPV2&nbsp; agonist [3]<\/li><li>5HT1A (serotonin) antagonist [3]<\/li><li>Endocannabinoid reuptake inhibitor [3]<\/li><li>A2-adrenoceptor agonist [<a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.2009.00515.x\" target=\"_blank\" rel=\"noreferrer noopener\">6<\/a>]<\/li><li>CB1 and CB2 receptors agonist [6]<\/li><\/ol>\n\n\n\n<h2>Final Thoughts: Why There\u2019s So\nMuch Hype Around CBG<\/h2>\n\n\n\n<p>CBG is the new kid on the block. There\u2019s been a lot of attention around CBD in recent years, but little focus on the other cannabinoids. Researchers are now starting to focus on the effects of peripheral cannabinoids we\u2019re seeing some very promising results. <\/p>\n\n\n\n<p>Many companies are now producing CBG versions\nof their oils, capsules, and extracts thanks to the unique differences CBG has\nto conventional cannabinoids like CBD and THC. Selective breeding, early\nharvesting, and isolation of CBG are now becoming more common within the\nindustry. <\/p>\n\n\n\n<p>CBG is non-psychoactive and is often used to\nnegate or reduce the psychoactive effects of THC products. <\/p>\n\n\n\n<p>This cannabinoid has shown promising effects\non fighting anxiety, promoting relaxation, supporting glaucoma and bacterial\ninfection, and curbing inflammation (especially in the gut). CBG also has\npowerful appetite-stimulating effects. <\/p>\n\n\n\n<p>Have you tried CBG? Tell us about your\nexperience in the comment section below. <\/p>\n\n\n\n<h2>References<\/h2>\n\n\n\n<ol><li>Nadolska, K., &amp; Go\u015b, R. (2008). Possibilities of applying cannabinoids&#8217; in the treatment of glaucoma. Klinika oczna, 110(7-9), 314-317.<\/li><li>Borrelli, F., Fasolino, I., Romano, B., Capasso, R., Maiello, F., Coppola, D., &#8230; &amp; Izzo, A. A. (2013). Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. Biochemical pharmacology, 85(9), 1306-1316.<\/li><li>Borrelli, F., Pagano, E., Romano, B., Panzera, S., Maiello, F., Coppola, D., &#8230; &amp; Izzo, A. A. (2014). Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Carcinogenesis, 35(12), 2787-2797.<\/li><li>Yee, N. S. (2015). Roles of TRPM8 ion channels in cancer: proliferation, survival, and invasion. Cancers, 7(4), 2134-2146.<\/li><li>Terzi\u0107, J., Grivennikov, S., Karin, E., &amp; Karin, M. (2010). Inflammation and colon cancer. Gastroenterology, 138(6), 2101-2114.<\/li><li>Cascio, M. G., Gauson, L. A., Stevenson, L. A., Ross, R. A., &amp; Pertwee, R. G. (2010). Evidence that the plant cannabinoid cannabigerol is a highly potent \u03b12\u2010adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. British journal of pharmacology, 159(1), 129-141.<\/li><li>Appendino, G., Gibbons, S., Giana, A., Pagani, A., Grassi, G., Stavri, M., &#8230; &amp; Rahman, M. M. (2008). Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Journal of natural products, 71(8), 1427-1430.<\/li><li>Cascio, M. G., Gauson, L. A., Stevenson, L. A., Ross, R. A., &amp; Pertwee, R. G. (2010). Evidence that the plant cannabinoid cannabigerol is a highly potent \u03b12\u2010adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. British journal of pharmacology, 159(1), 129-141.<\/li><li>Brierley, D. I., Samuels, J., Duncan, M., Whalley, B. J., &amp; Williams, C. M. (2016). Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. Psychopharmacology, 233(19-20), 3603-3613.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>CBG is often called the mother of all cannabinoids \u2014\u00a0and it may have a few extra tricks up its sleeve. <\/p>\n","protected":false},"author":10,"featured_media":21996,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3425,3575],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CBG (Cannabigerol): The Cannabis Stem Cell<\/title>\n<meta name=\"description\" content=\"Cannabigerol (CBG) is one of the newest trending cannabinoids. It offers its own independent set of benefits separate from CBD &amp; THC.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dailycbd.com\/en\/cbg\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CBG (Cannabigerol): The Cannabis Stem Cell\" \/>\n<meta property=\"og:description\" content=\"Cannabigerol (CBG) is one of the newest trending cannabinoids. 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