{"id":17186,"date":"2021-07-20T04:15:00","date_gmt":"2021-07-20T04:15:00","guid":{"rendered":"http:\/\/dailycbd.com\/en\/?p=17186"},"modified":"2022-07-20T13:49:27","modified_gmt":"2022-07-20T13:49:27","slug":"understanding-cbd-research","status":"publish","type":"post","link":"https:\/\/dailycbd.com\/en\/research\/","title":{"rendered":"Comprehensive List of CBD Research Studies"},"content":{"rendered":"\n<h2>Exhaustive List of Cannabidiol Research <\/h2>\n\n\n\n<p>To date, there have been well over 15,000 individual studies involving CBD. <\/p>\n\n\n\n<p>Most of these studies are molecular analysis and <em>in vitro<\/em> research&nbsp;\u2014 which offer limited evidence for the benefits of CBD. <\/p>\n\n\n\n<p>More recently, there&#8217;s been an aggressive push towards more high-quality <em>in vivo<\/em> and clinical trial studies. These are the studies that are really moving the needle when it comes to our academic understanding of cannabinoids. <\/p>\n\n\n\n<p>CBD is no longer stigmatized, and the early body or research has done enough to prove the safety of CBD. Now all eyes are on the future \u2014 what is CBD capable of? <\/p>\n\n\n\n<p>Does CBD actually work? Is there enough evidence to back up the suggested health benefits of this infamous cannabinoid? <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-1024x384.png\" alt=\"\" class=\"wp-image-32874\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/addiction-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Addiction<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/addiction\/\">CBD for addiction<\/a>:&nbsp;<\/strong><\/p>\n\n\n\n<ul><li>Regulates the function of dopamine in the brain<\/li><li>Alleviates common symptoms of drug withdrawal syndromes<\/li><li>CBD may reduce cravings for tobacco<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; addiction:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26056464\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as an intervention for addictive behaviors: a systematic review of the evidence.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26269227\/\" target=\"_blank\" rel=\"noreferrer noopener\">Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23685330\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol reduces cigarette consumption in tobacco smokers: preliminary findings.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20695034\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16489449\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol is an allosteric modulator at mu-and delta-opioid receptors.<\/a> (2006)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-1024x384.png\" alt=\"\" class=\"wp-image-32875\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/anxiety-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Anxiety<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/anxiety-depression\/\">CBD for anxiety<\/a>:&nbsp;<\/strong><\/p>\n\n\n\n<ul><li>Boosts GABA function in the brain&nbsp;<\/li><li>Regulates serotonin &amp; dopamine activity<\/li><li>Relaxes tight or tense muscles<\/li><li>Alleviates inflammation in the brain&nbsp;<\/li><li>Promotes a more restorative sleep<\/li><li>Reduces cortisol levels<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; anxiety:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32052321\/\" target=\"_blank\" rel=\"noreferrer noopener\">Study: Cannabidiol Holds Promise for Treating Psychosis<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30624194\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in anxiety and sleep: a large case series.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30157131\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30624194\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in Anxiety and Sleep: A Large Case Series.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30087591\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as a therapeutic alternative for post-traumatic stress disorder: From bench research to confirmation in human trials.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29057454\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5\u2010HT1A receptor\u2010mediated suppression of nausea and anxiety in rats.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28268256\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Regulation of Emotion and Emotional Memory Processing: Relevance for Treating Anxiety-related and Substance Abuse Disorders<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28861510\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28424834\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Prior Foot Shock Stress and Delta9-Tetrahydrocannabinol, Cannabidiolic Acid, and Cannabidiol on Anxiety-like Responding in the Light-dark Emergence Test in Rats<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28553229\/\" target=\"_blank\" rel=\"noreferrer noopener\">Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28268256\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety\u2010related and substance abuse disorders.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27768570\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effects of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26341731\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as a Potential Treatment for Anxiety Disorders<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26218440\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24923339\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23298518\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Anxiolytic Effect of Cannabidiol on Chronically Stressed Mice Depends on Hippocampal Neurogenesis: Involvement of the Endocannabinoid System<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24137134\/\" target=\"_blank\" rel=\"noreferrer noopener\">Does cannabidiol protect against adverse psychological effects of THC?<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22729452\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol, a Cannabis Sativa Constituent, as an Anxiolytic Drug<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20829306\/\" target=\"_blank\" rel=\"noreferrer noopener\">Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21307846\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20829306\/\" target=\"_blank\" rel=\"noreferrer noopener\">Neural Basis of Anxiolytic Effects of Cannabidiol (CBD) in Generalized Social Anxiety Disorder: a Preliminary Report<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21307846\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-naive Social Phobia Patients<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19124693\/\" target=\"_blank\" rel=\"noreferrer noopener\">Distinct Effects of \u03949-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing.<\/a> (2009)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14583744\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effects of cannabidiol (CBD) on regional cerebral blood flow.<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22290374\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effects of ipsapirone and cannabidiol on human experimental anxiety.<\/a> (1993)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6285406\/\" target=\"_blank\" rel=\"noreferrer noopener\">Action of cannabidiol on the anxiety and other effects produced by \u0394 9-THC in normal subjects.<\/a> (1982)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-1024x384.png\" alt=\"\" class=\"wp-image-32876\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/arthritis-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Arthritis<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/arthritis\/\">CBD for arthritis<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alleviates underlying inflammation<\/li><li>Relieves chronic pain<\/li><li>Prevents T-cell infiltration in rheumatoid arthritis<\/li><li>Promotes recovery of the joint tissue<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; arthritis:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30083539\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28885454\/\" target=\"_blank\" rel=\"noreferrer noopener\">Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21238581\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21683763\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Abnormal Cannabidiol Analogue O-1602 Reduces Nociception in a Rat Model of Acute Arthritis Via the Putative Cannabinoid Receptor GPR55<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14963641\/\" target=\"_blank\" rel=\"noreferrer noopener\">Oral Anti-inflammatory Activity of Cannabidiol, a Non-psychoactive Constituent of Cannabis, in Acute Carrageenan-induced Inflammation in the Rat Paw<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10920191\/\" target=\"_blank\" rel=\"noreferrer noopener\">The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.<\/a> (2000)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-1024x384.png\" alt=\"\" class=\"wp-image-32877\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/cancer-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Cancer<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/cancer\/\">CBD for cancer<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Regulates key immune cells tasked with cancer detection<\/li><li>May alleviate cancer-related pain<\/li><li>Supports sleep duration and quality<\/li><li>May boost hunger levels<\/li><li>May slow tumor growth<\/li><li>Alleviates nausea &amp; vomiting associated with chemotherapy<\/li><li>May support anxiety &amp; depression associated with a cancer diagnosis<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; cancer:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30815264\/\" target=\"_blank\" rel=\"noreferrer noopener\">Striking lung cancer response to self- administration of cannabidiol: A case report and literature review.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30660647\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31570484\/\" target=\"_blank\" rel=\"noreferrer noopener\">Concomitant Treatment of Malignant Brain Tumours With CBD \u2013 A Case Series and Review of the Literature.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30275207\/\" target=\"_blank\" rel=\"noreferrer noopener\">Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27586579\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24373545\/\" target=\"_blank\" rel=\"noreferrer noopener\">Inhibition of Colon Carcinogenesis by a Standardized Cannabis Sativa Extract With High Content of Cannabidiol<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22506672\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as Potential Anticancer Drug<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24204703\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol, a Non-psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells Through a Multitarget Effect<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23079154\/\" target=\"_blank\" rel=\"noreferrer noopener\">Triggering of the Trpv2 Channel by Cannabidiol Sensitizes Glioblastoma Cells to Cytotoxic Chemotherapeutic Agents<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23141881\/\" target=\"_blank\" rel=\"noreferrer noopener\">An Open-label Extension Study to Investigate the Long-term Safety and Tolerability of THC\/CBD Oromucosal Spray and Oromucosal Thc Spray in Patients With Terminal Cancer-related Pain Refractory to Strong Opioid Analgesics<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22594963\/\" target=\"_blank\" rel=\"noreferrer noopener\">Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23220503\/\" target=\"_blank\" rel=\"noreferrer noopener\">COX-2 and PPAR-\u03b3 Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22506672\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as potential anticancer drug.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23264851\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma-associated Herpesvirus-infected Endothelium<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22198381\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Inhibits Lung Cancer Cell Invasion and Metastasis Via Intercellular Adhesion Molecule-1<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23264851\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma\u2013Associated Herpesvirus-Infected Endothelium.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22231745\/\" target=\"_blank\" rel=\"noreferrer noopener\">Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21566064\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20859676\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21566064\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19896326\/\" target=\"_blank\" rel=\"noreferrer noopener\">Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20053780\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol enhances the inhibitory effects of \u03949-tetrahydrocannabinol on human glioblastoma cell proliferation and survival.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18387516\/\" target=\"_blank\" rel=\"noreferrer noopener\">A Comparative Study on Cannabidiol-induced Apoptosis in Murine Thymocytes and El-4 Thymoma Cells<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18025276\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as a Novel Inhibitor of Id-1 Gene Expression in Aggressive Breast Cancer Cells<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16728591\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16754784\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol-induced Apoptosis in Human Leukemia Cells: a Novel Role of Cannabidiol in the Regulation of P22phox and Nox4 Expression<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14692532\/\" target=\"_blank\" rel=\"noreferrer noopener\">Gamma-irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured Hl-60 Myeloblastic Leukemia Cells<\/a> (2003)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-1024x384.png\" alt=\"\" class=\"wp-image-32878\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/diabetes-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Diabetes<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/diabetes\/\">CBD for diabetes<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Helps curb appetite &amp; reduce weight<\/li><li>Protects the liver<\/li><li>Alleviates neuropathic pain<\/li><li>Alleviates other side effects of diabetes<\/li><li>Supports insulin function<\/li><li>Supports faster wound healing<\/li><li>Protects the insulin-secreting cells in the pancreas<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; diabetes:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32210914\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30898678\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27573936\/\" target=\"_blank\" rel=\"noreferrer noopener\">Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25212218\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20806080\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Protects Retinal Neurons by Preserving Glutamine Synthetase Activity in Diabetes<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21144973\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17714746\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16698671\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Lowers Incidence of Diabetes in Non-obese Diabetic Mice<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16400026\/\" target=\"_blank\" rel=\"noreferrer noopener\">Neuroprotective and Blood-retinal Barrier-preserving Effects of Cannabidiol in Experimental Diabetes<\/a> (2006)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-1024x384.png\" alt=\"\" class=\"wp-image-32879\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/epilepsy-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2>CBD Research: Epilepsy<\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/epilepsy-seizure\/\">CBD for epilepsy<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Alleviates convulsions<\/li><li>Protects the nerve cells<\/li><li>Modulates key receptors that regulate brain health<\/li><li>Alleviates neuro-inflammation<\/li><li>Supports GABA activity<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; epilepsy:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32656346\" target=\"_blank\" rel=\"noreferrer noopener\">Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32096470\/\" target=\"_blank\" rel=\"noreferrer noopener\">Epilepsy and cannabidiol: a guide to treatment.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32169600\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in treatment of refractory epileptic spasms: An open-label study.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32053110\/\" target=\"_blank\" rel=\"noreferrer noopener\">The proposed mechanisms of action of CBD in epilepsy.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32119035\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30917869\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cost-effectiveness of cannabinoids for pediatric drug-resistant epilepsy: protocol for a systematic review of economic evaluations.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30921021\/\" target=\"_blank\" rel=\"noreferrer noopener\">Update on Antiepileptic Drugs 2019<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31067185\/\" target=\"_blank\" rel=\"noreferrer noopener\">Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31247132\/\" target=\"_blank\" rel=\"noreferrer noopener\">Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30515765\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabis\u2010based products for pediatric epilepsy: A systematic review.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30582156\/\" target=\"_blank\" rel=\"noreferrer noopener\">Long\u2010term cannabidiol treatment in patients with Dravet syndrome: An open\u2010label extension trial.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30740695\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in patients with Lennox\u2010Gastaut syndrome: Interim analysis of an open\u2010label extension study.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31382177\/\" target=\"_blank\" rel=\"noreferrer noopener\">Drug\u2013drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31067185\/\" target=\"_blank\" rel=\"noreferrer noopener\">Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30460546\/\" target=\"_blank\" rel=\"noreferrer noopener\">Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31372958\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31003195\/\" target=\"_blank\" rel=\"noreferrer noopener\">Quality of life in adults enrolled in an open-label study of cannabidiol (CBD) for treatment-resistant epilepsy.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30258398\/\" target=\"_blank\" rel=\"noreferrer noopener\">Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29387536\/\" target=\"_blank\" rel=\"noreferrer noopener\">An interaction between warfarin and cannabidiol, a case report.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29395273\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30258395\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol for Treatment of Childhood Epilepsy\u2013A Cross-Sectional Survey.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29768152\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Cannabidiol on Drop Seizures in the Lennox\u2013Gastaut Syndrome.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30258398\/\" target=\"_blank\" rel=\"noreferrer noopener\">Potential clinical benefits of CBD-rich Cannabis extracts over purified cannabidiol (CBD) in treatment-resistant epilepsy: observational data meta-analysis.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28782097\/\" target=\"_blank\" rel=\"noreferrer noopener\">Interactions between cannabidiol and commonly used antiepileptic drugs.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28973916\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28089286\/\" target=\"_blank\" rel=\"noreferrer noopener\">Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29344464\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26800377\/\" target=\"_blank\" rel=\"noreferrer noopener\">CBD-enriched medical cannabis for intractable pediatric epilepsy: the current Israeli experience.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26724101\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26282273\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabinoids and Epilepsy<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26114620\/\" target=\"_blank\" rel=\"noreferrer noopener\">Drug\u2013drug interaction between clobazam and cannabidiol in children with refractory epilepsy.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26352816\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabinoids in the treatment of epilepsy.<\/a> (2015)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25029033\/\" target=\"_blank\" rel=\"noreferrer noopener\">Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24854149\/\" target=\"_blank\" rel=\"noreferrer noopener\">The case for medical marijuana in epilepsy.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24854329\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19906779\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18354002\/\" target=\"_blank\" rel=\"noreferrer noopener\">Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6129147\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.<\/a> (1982)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7028792\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hypnotic and Antiepileptic Effects of Cannabidiol.<\/a> (1981)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-1024x384.png\" alt=\"\" class=\"wp-image-32880\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ibd-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: IBD<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of CBD for IBD:<\/strong><\/p>\n\n\n\n<ul><li>Inhibits inflammation in the digestive tract<\/li><li>Prevents mast cell activation<\/li><li>Alleviates pain<\/li><li>May support microbiome diversity<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving <\/strong><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/colitis-crohns\/\"><strong>CBD &amp; IBD<\/strong><\/a><strong>:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29538683\/\" target=\"_blank\" rel=\"noreferrer noopener\">A randomized, double-blind, placebo-controlled, parallel-group, pilot study of cannabidiol-rich botanical extract in the symptomatic treatment of ulcerative colitis.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22815234\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in inflammatory bowel diseases: a brief overview.<\/a> (2013)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-1024x384.png\" alt=\"\" class=\"wp-image-32881\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/migraine-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Migraines &amp; Headaches<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/migraines\/\">CBD for headaches<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Relieves inflammation<\/li><li>Blocks the transmission of pain<\/li><li>May prevent the release of serotonin from platelets<\/li><li>May reduce vascular spasms<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; headaches:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22265864\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A2A receptor.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16672367\/\" target=\"_blank\" rel=\"noreferrer noopener\">Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.<\/a> (2006)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-1024x384.png\" alt=\"\" class=\"wp-image-32882\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/ms-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Multiple Sclerosis<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/multiple-sclerosis\/\">CBD for multiple sclerosis<\/a>:&nbsp;<\/strong><\/p>\n\n\n\n<ul><li>Resists the development of autoimmunity<\/li><li>Reduces neuroinflammation<\/li><li>Keeps T-cells from congregating around the nerves<\/li><li>Reduces muscle spasms<\/li><li>Supports bladder control<\/li><li>Alleviates nerve pain<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; MS:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30886530\/\" target=\"_blank\" rel=\"noreferrer noopener\">Daily Practice Managing Resistant Multiple Sclerosis Spasticity With Delta-9-Tetrahydrocannabinol: Cannabidiol Oromucosal Spray: A Systematic Review of Observational Studies<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30123217\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24525548\/\" target=\"_blank\" rel=\"noreferrer noopener\">Nabiximols (THC\/CBD Oromucosal Spray, Sativex\u00ae) in Clinical Practice &#8211; Results of a Multicenter, Non-Interventional Study (MOVE 2) in Patients with Multiple Sclerosis Spasticity.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23180178\/\" target=\"_blank\" rel=\"noreferrer noopener\">A Double-blind, Randomized, Placebo-controlled, Parallel-group Study of THC\/CBD Oromucosal Spray in Combination With the Existing Treatment Regimen, in the Relief of Central Neuropathic Pain in Patients With Multiple Sclerosis<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23851307\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23851307\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors.<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22973422\/\" target=\"_blank\" rel=\"noreferrer noopener\">Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21878454\/\" target=\"_blank\" rel=\"noreferrer noopener\">A placebo-controlled, parallel-group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex\u00ae(nabiximols).<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21449980\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis\u2010like disease in C57BL\/6 mice.<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20558502\/\" target=\"_blank\" rel=\"noreferrer noopener\">Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19183777\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabinoids in the management of spasticity associated with multiple sclerosis.<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18035205\/\" target=\"_blank\" rel=\"noreferrer noopener\">Oromucosal Delta9-tetrahydrocannabinol\/cannabidiol for Neuropathic Pain Associated With Multiple Sclerosis: an Uncontrolled, Open-label, 2-year Extension Trial<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17257464\/\" target=\"_blank\" rel=\"noreferrer noopener\">Meta-analysis of Cannabis Based Treatments for Neuropathic and Multiple Sclerosis-related Pain<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17891167\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabinoid control of neuroinflammation related to multiple sclerosis.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16553576\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sativex\u00ae: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15327041\/\" target=\"_blank\" rel=\"noreferrer noopener\">An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11854768\/\" target=\"_blank\" rel=\"noreferrer noopener\">he cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.<\/a> (2001)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9252798\/\" target=\"_blank\" rel=\"noreferrer noopener\">The perceived effects of smoked cannabis on patients with multiple sclerosis.<\/a> (1997)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-1024x384.png\" alt=\"\" class=\"wp-image-32883\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/nausea-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Nausea<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/nausea\/\">CBD for nausea<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Increases anandamide levels in the medulla oblongata<\/li><li>Alleviates inflammation<\/li><li>Relaxes muscle cramping and pain<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; nausea:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27438607\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Combined Oral Doses of \u0394(9)-tetrahydrocannabinol (THC) and Cannabidiolic Acid (CBDA) on Acute and Anticipatory Nausea in Rat Models<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23121618\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiolic Acid Prevents Vomiting in Suncus Murinus and Nausea-induced Behaviour in Rats by Enhancing 5-HT1A Receptor Activation<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24012649\/\" target=\"_blank\" rel=\"noreferrer noopener\">Suppression of Lithium Chloride-induced Conditioned Gaping (a Model of Nausea-induced Behaviour) in Rats (using the Taste Reactivity Test) With Metoclopramide Is Enhanced by Cannabidiolic Acid<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21827451\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol, a Non-psychotropic Component of Cannabis, Attenuates Vomiting and Nausea-like Behaviour Via Indirect Agonism of 5-HT(1A) Somatodendritic Autoreceptors in the Dorsal Raphe Nucleus<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21243485\/\" target=\"_blank\" rel=\"noreferrer noopener\">Interaction Between Non-psychotropic Cannabinoids in Marihuana: Effect of Cannabigerol (CBG) on the Anti-nausea or Anti-emetic Effects of Cannabidiol (CBD) in Rats and Shrews<\/a> (2011)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18816298\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Effects of Cannabidiol and Tetrahydrocannabinol on Motion-induced Emesis in Suncus Murinus<\/a> (2008)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11973447\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol, a Non-psychoactive Component of Cannabis and Its Synthetic Dimethylheptyl Homolog Suppress Nausea in an Experimental Model With Rats<\/a> (2002)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-1024x384.png\" alt=\"\" class=\"wp-image-32884\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/pain-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2>CBD Research: Pain<\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/pain\/\">CBD for pain<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Reduces inflammation<\/li><li>Alleviates common side-effects of pain<\/li><li>Supports nerve cell health<\/li><li>Activates pain receptors in the spinal cord and brain<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; pain:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33238607\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol for pain treatment: focus on pharmacology and mechanism of action.<\/a> (2020)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30938373\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30624194\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol in anxiety and sleep: a large case series.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30571957\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effects of cannabidiol in males and females in two different rat models of depression.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30157131\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31711352\/\" target=\"_blank\" rel=\"noreferrer noopener\">Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study.<\/a> (2019)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30152161\/\" target=\"_blank\" rel=\"noreferrer noopener\">Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29388063\/\" target=\"_blank\" rel=\"noreferrer noopener\">Medical cannabis for neuropathic pain.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29579828\/\" target=\"_blank\" rel=\"noreferrer noopener\">Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29797104\/\" target=\"_blank\" rel=\"noreferrer noopener\">Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28885454\/\" target=\"_blank\" rel=\"noreferrer noopener\">Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28548225\/\" target=\"_blank\" rel=\"noreferrer noopener\">Single and combined effects of \u03949\u2010tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy\u2010induced neuropathic pain.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27000108\/\" target=\"_blank\" rel=\"noreferrer noopener\">Neurophysiologic correlates of headache pain in subjects with major depressive disorder.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28445853\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol \u2013 Delta9-Tetrahydrocannabinol Interactions on Acute Pain and Locomotor Activity<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28680401\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28349233\/\" target=\"_blank\" rel=\"noreferrer noopener\">Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn\u2019s Disease, a Randomized Controlled Trial.<\/a> (2017)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28445853\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol-\u03949-tetrahydrocannabinol interactions on acute pain and locomotor activity.<\/a> (2017)<\/li><li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ejp.818\" target=\"_blank\" rel=\"noreferrer noopener\">Transdermal cannabidiol reduces inflammation and pain\u2010related behaviours in a rat model of arthritis.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26517407\/\" target=\"_blank\" rel=\"noreferrer noopener\">Transdermal cannabidiol reduces inflammation and pain\u2010related behaviors in a rat model of arthritis.<\/a> (2016)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24420962\/\" target=\"_blank\" rel=\"noreferrer noopener\">A double\u2010blind, randomized, placebo\u2010controlled, parallel group study of THC\/CBD spray in peripheral neuropathic pain treatment.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23180178\/\" target=\"_blank\" rel=\"noreferrer noopener\">A Double-blind, Randomized, Placebo-controlled, Parallel-group Study of THC\/CBD Oromucosal Spray in Combination With the Existing Treatment Regimen, in the Relief of Central Neuropathic Pain in Patients With Multiple Sclerosis<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23141881\/\" target=\"_blank\" rel=\"noreferrer noopener\">An Open-label Extension Study to Investigate the Long-term Safety and Tolerability of THC\/CBD Oromucosal Spray and Oromucosal Thc Spray in Patients With Terminal Cancer-related Pain Refractory to Strong Opioid Analgesics<\/a> (2013)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19896326\/\" target=\"_blank\" rel=\"noreferrer noopener\">Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19318283\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antinociceptive effect of the cannabinoid agonist, WIN 55,212\u20102, in the orofacial and temporomandibular formalin tests.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19220500\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cluster attacks responsive to recreational cannabis and dronabinol.<\/a> (2009)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17997224\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17712817\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex\u00ae, a cannabis\u2010based medicine.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18035205\/\" target=\"_blank\" rel=\"noreferrer noopener\">Oromucosal Delta9-tetrahydrocannabinol\/cannabidiol for Neuropathic Pain Associated With Multiple Sclerosis: an Uncontrolled, Open-label, 2-year Extension Trial<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17157290\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Non-psychoactive Cannabis Constituent Cannabidiol Is an Orally Effective Therapeutic Agent in Rat Chronic Inflammatory and Neuropathic Pain<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17257464\/\" target=\"_blank\" rel=\"noreferrer noopener\">Meta-analysis of Cannabis Based Treatments for Neuropathic and Multiple Sclerosis-related Pain<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17157290\/\" target=\"_blank\" rel=\"noreferrer noopener\">The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17712817\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of sativex\u03c1, a cannabis-based medicine.<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17712817\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of sativex, a cannabis-based medicine<\/a> (2007)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16489449\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol is an allosteric modulator at mu-and delta-opioid receptors.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16553576\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sativex\u00ae: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain.<\/a> (2006)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15313881\/\" target=\"_blank\" rel=\"noreferrer noopener\">Vanilloid TRPV1 Receptor Mediates The Antihyperalgesic Effect Of The Nonpsychoactive Cannabinoid, Cannabidiol, In A Rat Model Of Acute Inflammation<\/a> (2004)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14644587\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.<\/a> (2003)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11854768\/\" target=\"_blank\" rel=\"noreferrer noopener\">he cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.<\/a> (2001)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-1024x384.png\" alt=\"\" class=\"wp-image-32885\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/sleep-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Sleep<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/sleep\/\">CBD for sleep<\/a>:<\/strong><\/p>\n\n\n\n<ul><li>Sedative qualities promote faster sleep onset<\/li><li>May reduce nightmares<\/li><li>Regulates the sleep cycle and sleeping patterns<\/li><li>Alleviates common causes of insomnia<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving CBD &amp; sleep:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30014038\/\" target=\"_blank\" rel=\"noreferrer noopener\">A Cross-Sectional Study of Cannabidiol Users.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29674967\/\" target=\"_blank\" rel=\"noreferrer noopener\">No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.<\/a> (2018)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24845114\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol can improve complex sleep\u2010related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson&#8217;s disease patients: a case series.<\/a> (2014)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15118485\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of \u0394-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults.<\/a> (2004)<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-1024x384.png\" alt=\"\" class=\"wp-image-32886\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/weightloss-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2><strong>CBD Research: Weight Loss<\/strong><\/h2>\n\n\n\n<p><strong>Research supports the following effects of CBD for weight loss:<\/strong><\/p>\n\n\n\n<ul><li>Reduces appetite to curb eating habits<\/li><li>Alleviates chronic inflammation associated with obesity<\/li><li>Supports optimal hormone function<\/li><li>Alleviates digestive disorders &amp; inflammation<\/li><li>Supports mitochondria function (where sugar &amp; fat is burned for energy)<\/li><li>May reduce insulin resistance<\/li><li>Alleviates stress &amp; anxiety&nbsp;<\/li><\/ul>\n\n\n\n<p><strong>List of research studies involving <\/strong><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/weight-loss\/\"><strong>CBD &amp; weight loss<\/strong><\/a><strong>:<\/strong><\/p>\n\n\n\n<ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22421529\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabis exposure associated with weight reduction and \u03b2-cell protection in an obese rat model.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22133305\/\" target=\"_blank\" rel=\"noreferrer noopener\">A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men.<\/a> (2012)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20428110\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol Attenuates the Appetitive Effects of \u03949-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis.<\/a> (2010)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16148436\/\" target=\"_blank\" rel=\"noreferrer noopener\">Endocannabinoids in the regulation of appetite and body weight<\/a> (2005)<\/li><\/ol>\n\n\n\n<h2>Why CBD Research is So Important<\/h2>\n\n\n\n<p>Since the prohibition on cannabis was\nlifted in the Western world, there\u2019s been a great deal of confusion as to how\nto best regulate CBD and other cannabis-based products. <\/p>\n\n\n\n<p>Pharmaceutical companies are in a race to create and patent cannabinoid-based prescription drugs like <a href=\"https:\/\/www.epidiolex.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Epidiolex<\/a> or <a href=\"https:\/\/www.gwpharm.com\/healthcare-professionals\/sativex\" target=\"_blank\" rel=\"noreferrer noopener\">Sativex<\/a>.<\/p>\n\n\n\n<p>On the supply side, botanical extract\nmanufacturers are keen to meet growing market demands, but at the same time\nmust carefully navigate an uncertain regulatory environment. <\/p>\n\n\n\n<p><strong>The convergence of these conflicting interests is a recipe for trouble and raises some important areas of concern: <\/strong><\/p>\n\n\n\n<ul><li>What do we really know about the short- and long-term safety of CBD?<\/li><li>What conditions can CBD be used to support?<\/li><li>Are there health conditions that could be made worse by CBD?<\/li><li>How does CBD interact with prescription and non-prescription medications?<\/li><\/ul>\n\n\n\n<h2>Five Types of CBD Research<\/h2>\n\n\n\n<p>As the CBD industry continues to evolve \u2014\nthere\u2019s an endless supply of questions scientists will continue to seek answers\nfor. <\/p>\n\n\n\n<p>Answering these questions will rely on\nscrutinous scientific exploration. Through different levels of research, CBD\ncan be vetted to the same stringent standards for safety and efficacy as any\nother drug or botanical extract.<\/p>\n\n\n\n<p><strong>CBD\nresearch falls into three main categories:<\/strong><\/p>\n\n\n\n<ol><li><strong>Level 1: Basic Research\n     \u2014 <\/strong>low-level research to map the structural makeup\n     and chemical properties<\/li><li><strong>Level 2: <em>In\n     Vitro<\/em> Studies<\/strong> (using cell\n     cultures)&nbsp;\u2014&nbsp;low-level research; begins to explore the toxicity\n     of a substance in live cells and tissues<\/li><li><strong>Level 3: <em>In\n     Vivo<\/em> Studies<\/strong> (using real living organisms)\n     \u2014&nbsp;higher-level research involving living non-human animals<\/li><li><strong>Level 4: Clinical Trials \u2014<\/strong>&nbsp;conducted\n     on real humans in 4 different stages (I, II, III, and IV)<\/li><li><strong>Level 5: Meta-analysis \u2014<\/strong> a review of published preclinical and clinical research; provides\n     the highest level of evidence possible by pooling the data from similar\n     studies.<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1024\" height=\"509\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-1024x509.jpg\" alt=\"\" class=\"wp-image-17251\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-1024x509.jpg 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-300x149.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-768x381.jpg 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-180x89.jpg 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-283x141.jpg 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-54x27.jpg 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-330x164.jpg 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-420x209.jpg 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-74x37.jpg 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels-60x30.jpg 60w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/12\/research-levels.jpg 1611w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>So, how does the scientific process work, and what are the methods and stages of research that will ultimately tell us everything we need to know about the benefits and risks of CBD?<\/strong><\/p>\n\n\n\n<p>Let\u2019s take a closer look at the different\nlevels of scientific research for studying CBD. <\/p>\n\n\n\n<p>Here we provide a glimpse into the painstaking process behind the splashy headlines that appear on an almost daily basis about CBD being nature\u2019s cure for everything from <a href=\"http:\/\/dailycbd.com\/en\/condition\/acne\/\">acne<\/a> to cancer.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-1024x384.png\" alt=\"\" class=\"wp-image-32893\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/preliminary-research-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3>Level 1: Basic Research \u2014 Is CBD\nSafe?<\/h3>\n\n\n\n<p>CBD is widely regarded as being safe and non-toxic and that\u2019s great news. But, is CBD completely free of any <a href=\"https:\/\/dailycbd.com\/en\/cbd-side-effects\/\">side effects<\/a>? <\/p>\n\n\n\n<p>This is what basic research studies are\ndesigned to explore. Rather than looking at specific benefits of a compound,\nthey assess how much of the compound is needed to produce toxic effects on the\nbody and explore the chemical makeup of CBD or other cannabis extracts. <\/p>\n\n\n\n<p>A common method of assessing toxicity is to give increasing doses of a compound (like CBD) to rats until 50% of the sample population dies. This gives us the <a href=\"https:\/\/simple.wikipedia.org\/wiki\/LD50\" target=\"_blank\" rel=\"noreferrer noopener\">LD50<\/a> of a compound (lethal dose for 50% of the population). <\/p>\n\n\n\n<p>Careful observation is noted on how the\nrats die, which gives us a clue as to the toxic side-effects of the compound. <\/p>\n\n\n\n<p>During the first phases of basic research, the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19568374\" target=\"_blank\" rel=\"noreferrer noopener\">structural, molecular, and chemical properties of a substance<\/a> are determined. This early research tells us that CBD is soluble in fat but not in water and that its molecular formula is <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/#query=C21H30O2\" target=\"_blank\" rel=\"noreferrer noopener\">C21H30O2<\/a>. <\/p>\n\n\n\n<p><strong>It&#8217;s because of this research that we know CBD looks like this: <\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-1024x683.png\" alt=\"\" class=\"wp-image-27096\" width=\"490\" height=\"326\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-1024x683.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-300x200.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-768x512.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-180x120.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-283x189.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-54x36.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-330x220.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-420x280.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-74x49.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule-45x30.png 45w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2020\/12\/cbd-molecule.png 1200w\" sizes=\"(max-width: 490px) 100vw, 490px\" \/><\/figure><\/div>\n\n\n\n<h4>Examples of structural property\nstudies involving CBD <\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td>\n  <strong>Study Topic<\/strong>\n  <\/td><td>\n  <strong>Article Authors<\/strong>\n  <\/td><td>\n  <strong>Level of Study<\/strong>\n  <\/td><\/tr><tr><td>\n  The Structure of\n  Cannabidiol\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/5879214\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Mechoulam   et al., 1963<\/a>   <\/td><td>\n  1\n  <\/td><\/tr><tr><td>\n  Separating\n  Cannabinoids\n  <\/td><td>\n  Lerner., 1963\n  <\/td><td>\n  1\n  <\/td><\/tr><tr><td>\n  Identification of\n  CBD Sub-Groups \n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6715\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Harvey.,   1976<\/a>   <\/td><td>\n  1\n  <\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-1024x384.png\" alt=\"\" class=\"wp-image-32892\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vitro-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3>Level 2: In Vitro Studies \u2014 Testing On Living Cells<\/h3>\n\n\n\n<p>Once the structural and chemical\nproperties of CBD are measured and cataloged, researchers introduce controlled\namounts of the compound to cell and tissue cultures. <\/p>\n\n\n\n<p>Tissue cultures consist of living cells\nthat are grown in test tubes and Petri dishes (in vitro, literally translated,\nmeans \u201cin glass\u201d). The goal of this research is to begin to find out how it\nwill interact with living cells using highly controlled environments. <\/p>\n\n\n\n<p>The in vitro process allows scientists to\ncreate precisely controlled environments using a single cell or tissue type, in\nwhich all variables can be controlled.<\/p>\n\n\n\n<p><strong>In\nthis phase of research, it\u2019s possible to design an experiment that asks and\nanswers a single question about CBD \u2014<\/strong> which is not\npossible in a living human with many systems communicating and influencing each\nother at all times.<\/p>\n\n\n\n<h4>Examples of In Vitro CBD Studies<\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td>\n  <strong>Study Topic<\/strong>\n  <\/td><td>\n  <strong>Article Authors<\/strong>\n  <\/td><td>\n  <strong>Level of Study<\/strong>\n  <\/td><\/tr><tr><td>\n  CBD &amp; Stroke \n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26497782\" target=\"_blank\" rel=\"noreferrer noopener\">Hind   et al., 2016<\/a>   <\/td><td>\n  2\n  <\/td><\/tr><tr><td>\n  CBD &amp;\n  Inflammatory Bowel Disease\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24238999\" target=\"_blank\" rel=\"noreferrer noopener\">Harvey   et al., 2014<\/a>   <\/td><td>\n  2\n  <\/td><\/tr><tr><td>\n  CBD &amp; Cancer\n  Cells\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19914218\" target=\"_blank\" rel=\"noreferrer noopener\">Ramer   et al., 2010<\/a>   <\/td><td>\n  2\n  <\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-1024x384.png\" alt=\"\" class=\"wp-image-32891\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/in-vivo-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3>Level 3: In Vivo Studies \u2014 Testing On Live Animals<\/h3>\n\n\n\n<p>The next level of research is in vivo\nresearch \u2014 which is conducted on live animals and allows scientists to obtain\nmore accurate information about the effectiveness, safety, and toxicity of the\nsubstance. By using real living systems, researchers can test how a compound\nwill affect the organism as a whole. In vivo testing can compare effects across\ndifferent species. Usually, mammals are chosen for in vivo medical research\nsince their physiology is most similar to ours. <\/p>\n\n\n\n<p>Gradually, the research is advanced from rodent species (mice, rats, rabbits, etc.) to larger species (<a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/oil-for-cats\/\">cats<\/a>, <a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/oil-for-dogs\/\">dogs<\/a>, non-human primates). This can reveal how response differs from one species to another and can also help researchers narrow down a safe starting dose when it comes time to test on humans.<\/p>\n\n\n\n<p>With this information, we can start to\nunderstand how CBD is likely to travel into and through the body, and how much\nthe body can safely handle. This information is used as a basis for the next\nstages of research that look closer at the actual interaction CBD has on the\nbody. <\/p>\n\n\n\n<p><strong>In\nvivo research also determines:<\/strong><\/p>\n\n\n\n<ol><li><strong>How CBD travels through      the body \u2014<\/strong> how quickly and efficiently it is      absorbed into the bloodstream<\/li><li><strong>How CBD is broken down<\/strong> \u2014      whether this is done in the kidneys, liver, or elsewhere in the body<\/li><li><strong>How safe or toxic CBD and its metabolites are      \u2014&nbsp;<\/strong>sometimes a compound is found safe through      <em>in vitro<\/em> research but shows      toxic effects when given to live animals. For example, currently there is      no known LD50 for CBD in humans; however, a <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22129319\" target=\"_blank\" rel=\"noreferrer noopener\">2011 study found doses of 200-300mg\/kg<\/a> to be lethal in some rhesus monkeys.<\/li><li><strong>How the compound is excreted from the body <\/strong>\u2014 compounds may leave the body through the urine, feces, or even      through the skin<\/li><li><strong>The effects of CBD for      certain conditions or symptoms \u2014<\/strong> using animals      with health issues, we can test CBD to see if it improves the condition or      makes it worse<\/li><\/ol>\n\n\n\n<p>A potential limitation of <em>in vivo<\/em> research on CBD is that each\nspecies contains different receptor counts. Although all mammals have\nendocannabinoid systems, the densities and distributions of endocannabinoid\nreceptors can vary a lot from one species to the next \u2014 therefore changing the\neffects of CBD. <\/p>\n\n\n\n<p>For example, rats and rhesus monkeys have <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2308954\" target=\"_blank\" rel=\"noreferrer noopener\">higher cannabinoid receptor densities than humans<\/a> in some parts of their brains and lower density in other parts. This makes it difficult to extrapolate how CBD will act in a human compared to an experimental animal.<\/p>\n\n\n\n<p>Currently, the FDA and associated regulatory agencies are requiring researchers to provide data to <a href=\"https:\/\/www.uab.edu\/medicine\/adda\/images\/131205%20Tox%20Animal%20Models.pdf.\" target=\"_blank\" rel=\"noreferrer noopener\">substantiate their choice of animal species<\/a> for their studies. But even with these precautions in place, it\u2019s important to keep in mind that drugs that prove safe and effective in animal testing might have different effects on humans.<\/p>\n\n\n\n<h4>Examples of In Vivo CBD Research<\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td>\n  <strong>Study Topic<\/strong>\n  <\/td><td>\n  <strong>Article Authors<\/strong>\n  <\/td><td>\n  <strong>Level of Study<\/strong>\n  <\/td><\/tr><tr><td>\n  CBD for Wound\n  Healing\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30088305\" target=\"_blank\" rel=\"noreferrer noopener\">Klein   et al., 2018<\/a>   <\/td><td>\n  3\n  <\/td><\/tr><tr><td>\n  CBD for Fear\n  &amp; Anxiety\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27296152\" target=\"_blank\" rel=\"noreferrer noopener\">Norris   et al., 2016<\/a>   <\/td><td>\n  3\n  <\/td><\/tr><tr><td>\n  CBD for Epilepsy\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19906779\" target=\"_blank\" rel=\"noreferrer noopener\">Jones   et al., 2010<\/a>   <\/td><td>\n  3\n  <\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-1024x384.png\" alt=\"\" class=\"wp-image-32894\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/clinical-research-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3><strong>Level 4: <\/strong>Clinical Research \u2014&nbsp;Testing On Humans<\/h3>\n\n\n\n<p>Once sufficient in vitro and in vivo\nresearch has been conducted to establish that CBD might be reasonably effective\nand safe for a particular purpose clinical studies, i.e. experiments on human\nvolunteers, can begin.<\/p>\n\n\n\n<p>Clinical research is considered the\nhighest level of experimental research because it\u2019s done directly on humans.\nThese studies can be used to confirm the pharmacokinetics from in vivo studies\nand test whether the benefits in laboratory animals can be replicated in\nhumans. <\/p>\n\n\n\n<p><strong>Clinical\ntrials may be used to assess the following: <\/strong><\/p>\n\n\n\n<ol><li>The pathway CBD takes through the body, from absorption to\n     distribution to elimination<\/li><li>The clinical\n     effects of CBD (ie. its health benefits)The absence or presence of\n     side-effects<\/li><li>The optimal dose needed for CBD to be used effectively in humans<\/li><\/ol>\n\n\n\n<p>The quality of clinical trials can vary\nwidely, and there are some key elements to consider when assessing the quality\nof a particular trial. <\/p>\n\n\n\n<h4>Placebo-Control<\/h4>\n\n\n\n<p>A placebo control is a critical component of a clinical trial to ensure the results of the study weren\u2019t caused by the participants\u2019 expectations. To apply a placebo control, a sham treatment is given to one group (an inactive compound that looks like CBD but isn\u2019t). <\/p>\n\n\n\n<p>This procedure is designed to eliminate the placebo effect \u2014 where symptoms may improve after a patient <em>believes<\/em> they were using a medication, even if there were no active compounds in the treatment. The placebo effect has been found to occur in about <a href=\"https:\/\/people.umass.edu\/curtis\/academics\/researchtoolbox\/pdfs\/Placebos_Brody.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">40% of study participants<\/a>.<\/p>\n\n\n\n<h4>Randomization<\/h4>\n\n\n\n<p>To make sure there are no patterns in the treatment group or placebo control groups that may affect results, statistical randomization is used to separate the participants. <\/p>\n\n\n\n<p>This process assures that the\nparticipants are equally distributed to each arm of the study. <\/p>\n\n\n\n<p>Randomization prevents all participants\nwith a particular characteristic, such as age, sex, or a genetic risk factor to\nbe placed in the same group. It also prevents conscious or subconscious\nresearcher bias from influencing the experiment, such as placing all of the\nparticipants most likely to have a good (or bad) response in the same group.<\/p>\n\n\n\n<h4>Blinding <\/h4>\n\n\n\n<p>Blinding is used to make it unknown to the study participants and researchers which participants are getting a dose of CBD or placebo. This eliminates bias by not revealing which treatment is being administered. <\/p>\n\n\n\n<p>There are two categories of blinding:<\/p>\n\n\n\n<p><strong>Single-blind\n\u2014<\/strong> the participant is not informed of which treatment\nthey are receiving <\/p>\n\n\n\n<p>This prevents the participants\u2019 preconceived ideas or expectations from influencing their responses. Single blinding can help eliminate the placebo effect. <\/p>\n\n\n\n<p>Also, many studies rely on subjective\nreports by participants about their symptoms and overall experience. Single\nblinding eliminates these potential biases. If they think they\u2019re getting the\ntreatment, they may answer the questions differently than if they knew they\nwere taking the placebo. So it\u2019s best to keep this part a mystery until the\ntrial is over. <\/p>\n\n\n\n<p><strong>Double-blind\n\u2014<\/strong>&nbsp; both the\nparticipant and the researcher don\u2019t know which treatment is being administered\nto which participant. This prevents the researcher from consciously or\nsubconsciously behaving differently toward participants in ways that could\ninfluence the results of the study.<\/p>\n\n\n\n<p>The best clinical trials use double-blinding in their research model.&nbsp;<\/p>\n\n\n\n<h4>Different Levels of Clinical\nTrials <\/h4>\n\n\n\n<h5>A) Phase I Trials <\/h5>\n\n\n\n<p>Phase I trials are the first studies in\nwhich a drug is given to a small group of people (up to 80). In this phase, the\nbest route of administration, i.e. by mouth, inhaled, topical, injected into\nthe bloodstream, etc. is determined, as well as ideal dosing levels and\nfrequency.<\/p>\n\n\n\n<p>If this study proves safe and shows\nimprovement, the study can move on to phase II. <\/p>\n\n\n\n<h5>B) Phase II Trials <\/h5>\n\n\n\n<p>Phase II clinical trials obtain further\nsafety information and begin to collect data on effectiveness. These studies\ninvolve larger numbers of participants \u2014 usually between 100 to 300.<\/p>\n\n\n\n<h5>C) Phase III Trials <\/h5>\n\n\n\n<p>Phase III clinical trials compare the new\ndrug to a drug that is commonly used as the standard of care for a particular\ncondition. These studies use large numbers of participants (from 300 to 3,000\nor more).<\/p>\n\n\n\n<p>Once a drug is approved by the FDA, the manufacturer may elect or they may be required by regulatory agencies to conduct the fourth phase of trials. <\/p>\n\n\n\n<h5>D) Phase IV Trials <\/h5>\n\n\n\n<p>Phase IV clinical trials determine\nlong-term side effects and the risk-to-benefit ratio for someone who may need\nto use the drug ongoing over a long period of time. These studies use the\ngreatest number of people, with participants potentially numbering in the\nthousands [13]. They also tend to cover several months, or even years to\ncollect long-term health data.<\/p>\n\n\n\n<h5>E) Epidemiological Research<\/h5>\n\n\n\n<p>Once a CBD-based drug has been\nFDA-approved it can be included in epidemiological research. Epidemiology seeks\nto understand the frequency and distribution patterns of a disease or health\ncondition.<\/p>\n\n\n\n<p>Part of epidemiology involves studying the effects of interventions, which can include eliminating exposure to environmental toxins and pollutants, changing lifestyle behaviors that predispose people to develop certain conditions, and also the effects of drugs or other substances, such as CBD, on the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19547627\" target=\"_blank\" rel=\"noreferrer noopener\">distribution of a particular disease within the population<\/a>.<\/p>\n\n\n\n<p>To better understand the value of clinical CBD studies, the types of information they provide, and their drawbacks, let\u2019s take a close look at a few examples.<\/p>\n\n\n\n<h4>Examples of Clinical Trials Involving CBD<\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td>\n  <strong>Study Topic<\/strong>\n  <\/td><td>\n  <strong>Article Authors<\/strong>\n  <\/td><td>\n  <strong>Level of Study<\/strong>\n  <\/td><\/tr><tr><td>\n  CBD for Crohn\u2019s\n  Disease\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28349233\" target=\"_blank\" rel=\"noreferrer noopener\">Naftali et al., 2017<\/a>   <\/td><td>\n  4\n  <\/td><\/tr><tr><td>\n  CBD for Anxiety\n  and Insomnia\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30624194\" target=\"_blank\" rel=\"noreferrer noopener\">Shannon et al., 2019<\/a><\/td><td>\n  4\n  <\/td><\/tr><tr><td>\n  CBD for Healthy\n  People\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30374683\" target=\"_blank\" rel=\"noreferrer noopener\">Taylor   et al., 2018<\/a>   <\/td><td>\n  4\n  <\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"384\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-1024x384.png\" alt=\"\" class=\"wp-image-32897\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-1024x384.png 1024w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-300x113.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-768x288.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-1536x576.png 1536w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-180x68.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-283x106.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-54x20.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-330x124.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-420x158.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-74x28.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header-80x30.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/09\/meta-analysis-header.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3>Level 5: Meta-Analysis \u2014 Comparing Data From Multiple Studies<\/h3>\n\n\n\n<p>A meta-analysis is a type of systematic review\n\u2014 a study of studies \u2014 in which the data from multiple studies on a particular\naspect of CBD are compiled and evaluated together. A meta-analysis can include\neither pre-clinical or clinical studies. <\/p>\n\n\n\n<p>The higher the level of studies used in the\nmeta-analysis the stronger the evidence will be for a particular effect. For\nexample, a meta-analysis that uses double-blind, placebo-controlled, randomized\nhuman trials will produce stronger evidence than a meta-analysis of animal\nstudies. <\/p>\n\n\n\n<h4>Examples of Meta-Analysis\nInvolving CBD<\/h4>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td>\n  <strong>Study Topic<\/strong>\n  <\/td><td>\n  <strong>Article Authors<\/strong>\n  <\/td><td>\n  <strong>Level of Study<\/strong>\n  <\/td><\/tr><tr><td>\n  CBD for Epilepsy\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31731110\" target=\"_blank\" rel=\"noreferrer noopener\">de   Carvalho Reis et al., 2019<\/a>   <\/td><td>\n  5\n  <\/td><\/tr><tr><td>\n  CBD for Stroke\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25492113\" target=\"_blank\" rel=\"noreferrer noopener\">England   et al., 2015<\/a>   <\/td><td>\n  5\n  <\/td><\/tr><tr><td>\n  Effects of CBD on\n  the Circulatory System\n  <\/td><td>   <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20558502\" target=\"_blank\" rel=\"noreferrer noopener\">Wade   et al., 2010<\/a>   <\/td><td>\n  5\n  <\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<h2>Key Takeaways: What&#8217;s The Future of CBD Research? <\/h2>\n\n\n\n<p>Cannabis research was curtailed for nearly 80\nyears due to prohibition. Now scientists are working hard to fill in the gaps\nbut at the same time the regulatory landscape is uncertain and the information\navailable to CBD consumers can be confusing. <\/p>\n\n\n\n<p><strong>Scientists\nare using different research models to answer some of the biggest questions we\nhave around the use of CBD: <\/strong><\/p>\n\n\n\n<ul><li>How safe is CBD? <\/li><li>What can CBD be used to help? <\/li><li>Can CBD worsen any conditions?<\/li><li><a href=\"https:\/\/dailycbd.com\/en\/drug-interactions\/\">How does CBD interact with medications?<\/a><\/li><\/ul>\n\n\n\n<p>Knowing some of the how\u2019s and why\u2019s of\nscientific research can help you interpret the latest headlines about CBD so\nyou can be an informed consumer. <\/p>\n\n\n\n<p><strong>Scientific\nmedical studies can be divided into five different categories: <\/strong><\/p>\n\n\n\n<ol><li><strong>Level 1: Basic Research \u2014<\/strong>&nbsp;early\n     research for assessing the molecular structure and chemical properties<\/li><li><strong>Level 2: In-Vivo Research \u2014&nbsp;<\/strong>highly-controlled research for assessing beneficial and toxic\n     effects of CBD on isolated cells and tissues grown in test tubes <\/li><li><strong>Level 3: In-Vitro Research \u2014<\/strong>&nbsp;real testing of CBD on living systems to assess safety and\n     effectiveness <\/li><li><strong>Level 4: Clinical trials \u2014&nbsp;<\/strong>testing on humans to assess dose, efficacy, and comparison of CBD\n     with other compounds<\/li><li><strong>Level 5: Meta-Analysis \u2014<\/strong>\n     continued data analysis of multiple similar studies on a particular effect\n     profile<\/li><\/ol>\n\n\n\n<p>Through continued research, building up from basic research all the way up to large-scale meta-analysis, we can seek a deeper understanding of how CBD works, and how to use it both safely and effectively for a wide range of different symptoms and health conditions. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>CBD is one of the most well-researched compounds in the natural world.<\/p>\n","protected":false},"author":1,"featured_media":18179,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[163,925,3578],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Comprehensive List of CBD Research Studies \u2014\u00a0Daily CBD<\/title>\n<meta name=\"description\" content=\"CBD research has ramped up a lot in recent years \u2014 but not all research is equal. 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