{"id":14108,"date":"2019-11-22T08:26:00","date_gmt":"2019-11-22T08:26:00","guid":{"rendered":"http:\/\/dailycbd.com\/en\/?p=14108"},"modified":"2022-01-07T13:20:24","modified_gmt":"2022-01-07T13:20:24","slug":"cbd-bioavailability","status":"publish","type":"post","link":"https:\/\/dailycbd.com\/en\/cbd-bioavailability\/","title":{"rendered":"CBD Bioavailability: What Does it Mean Why is it so Important?"},"content":{"rendered":"\n

CBD offers great benefits<\/a> for health and healing. Its high safety profile and non-addictive nature make it an appealing alternative to many conventional drugs.<\/p>\n\n\n\n

But, in order to be effective, CBD has to reach your endocannabinoid system<\/a>. This means it first needs to be absorbed into your bloodstream, a concept known as bioavailability<\/em>. <\/p>\n\n\n\n

Once there, it has to stay in circulation\nlong enough to be delivered to the organs and tissues where it is needed.<\/p>\n\n\n\n

So,\nhow much of the CBD you take actually gets absorbed and used?  <\/strong><\/p>\n\n\n\n

That depends on a process known as pharmacokinetics<\/em> (how compounds are\nprocessed by the body). <\/p>\n\n\n\n

In short, pharmacokinetics refers to the\nsum of your body\u2019s mechanisms for absorption and elimination, the\ncharacteristics of CBD itself, and numerous external factors that can either\nhelp or hinder the way you assimilate and use CBD.<\/p>\n\n\n\n

Additionally, the route of entry, or delivery method, has a lot to do with how much and how quickly CBD enters the bloodstream.<\/p>\n\n\n\n

Oral CBD: Capsules, Oils, and\nEdibles<\/h2>\n\n\n\n

Oral CBD formulations, such as CBD oils and tinctures<\/a>, capsules<\/a>, gummies<\/a>, chocolates<\/a>, other edibles, and beverages<\/a> are among the most popular ways to consume CBD. <\/p>\n\n\n\n

However, oral CBD has the lowest bioavailability of all delivery forms. <\/strong><\/p>\n\n\n\n

On average, ingested CBD has a bioavailability of between 6-19% [2<\/a>, 3<\/a>, 4<\/a>].<\/p>\n\n\n\n

One reason for this is that CBD is not\nreadily absorbed when ingested and as a result, most of it is excreted without\nexerting any effects.<\/p>\n\n\n\n

This is due to the fact that CBD is fat-soluble (as opposed to water-soluble), which makes it a challenge for the body to absorb. <\/p>\n\n\n\n

Additionally, digestive acids and enzymes\ndestroy a large percentage of CBD before it has a chance to be absorbed. And\nthe small amount that gets through the intestinal wall is subject to being\nmetabolized by the liver before it reaches the rest of the body.<\/p>\n\n\n\n

The half-life of oral CBD, i.e. the\namount of time it takes for half of the CBD to leave the bloodstream, may be\nfaster than other delivery methods. Half-lives from 10 to 17 hours have been\nreported for high dosages between 750 mg and 1500 mg [1<\/a>].\n<\/p>\n\n\n\n

Peak\nlevels of oral CBD tend to be lower than other delivery forms.<\/strong> <\/p>\n\n\n\n

In one experiment, cookies infused with 40 mg of CBD produced peak blood CBD levels between 1.5 and 3 hours after ingestion [5<\/a>]. <\/p>\n\n\n\n

However, the low absorption of oral CBD\nmay be offset by certain advantages \u2014 such as a longer duration. A laboratory\nanimal study found the average amount of time an orally consumed CBD molecule\nstays in the body, known as the \u201cmean residence time\u201d, was 4.2 hours. <\/p>\n\n\n\n

By contrast, the mean residence time for\ninjected CBD, in the same study, was 3.3 hours [3]. <\/p>\n\n\n\n

Oral CBD has also been found to lead to higher brain levels when compared to inhalation methods in animal studies [6<\/a>]. <\/strong><\/p>\n\n\n\n

Bioavailability of CBD: Vaping vs Oral Consumption<\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n

Inhaled CBD: Vaping and Smoking<\/h2>\n\n\n\n

Inhalation is an efficient way to consume CBD because it bypasses the digestive tract and liver allowing CBD to be readily absorbed through the thin membranes that line the air sacs of the lungs (alveoli) where it enters directly into the bloodstream. <\/p>\n\n\n\n

There are several ways to inhale CBD:<\/p>\n\n\n\n

1. Smoking<\/h3>\n\n\n\n

The most basic inhalation form is smoking. <\/p>\n\n\n\n

In this case, the hemp cigarette<\/a> contains unprocessed CBD-rich hemp buds<\/a> (as opposed to high-THC cannabis). Smoking has a bioavailability of 31% and a single CBD cigarette containing about 19 mg of CBD can produce peak blood levels within 3 minutes [5]. <\/p>\n\n\n\n

The half-life of smoked CBD averages 31\nhours. <\/p>\n\n\n\n

The downside to smoking is that it produces combustion by-products which can irritate and, in some instances damage the lungs. These include fluorene, pyrene, acrylonitrile, and acrylamide [7<\/a>].<\/p>\n\n\n

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\r\n\t\t\t\tNeurogan Neurogettes 1 \u2013 10 pack<\/strong>\r\n\t\t\t<\/h4>\r\n\t\t<\/div>\r\n\r\n\t\t
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