{"id":37906,"date":"2022-04-15T09:43:47","date_gmt":"2022-04-15T09:43:47","guid":{"rendered":"https:\/\/dailycbd.com\/en\/?page_id=37906"},"modified":"2022-08-16T12:00:13","modified_gmt":"2022-08-16T12:00:13","slug":"benazepril","status":"publish","type":"page","link":"https:\/\/dailycbd.com\/en\/drug-interactions\/benazepril\/","title":{"rendered":"Does CBD Interact With Benazepril Hydrochloride (Lotensin)?"},"content":{"rendered":"\n

Does CBD Interact With Benazepril Hydrochloride (Lotensin)?<\/h2>\n\n\n\n

Yes. CBD can interact with benazepril hydrochloride<\/strong>. They may have a mild to mostly moderate level of interaction.<\/p>\n\n\n\n

CBD is an agonist to benazepril hydrochloride, which means taking them together could increase benazepril hydrochloride’s effects. This interaction could cause side effects like a sudden decrease in blood pressure, headache, fainting, etc.<\/p>\n\n\n\n

CBD can interact with benazepril hydrochloride in two ways:<\/strong><\/p>\n\n\n\n

<\/a>A. CBD Can Increase Benazepril Hydrochloride’s Effects On the Body (Agonistic Interaction)<\/h3>\n\n\n\n

When two substances show similar effects on the body, they’re called agonists to each other. Thus, consuming such substances together can cause them to exert more powerful effects, which may become dangerous.  <\/p>\n\n\n\n

Benazepril hydrochloride can decrease blood pressure by inhibiting the actions of the angiotensin-converting enzyme (ACE) and preventing the conversion of angiotensin I to angiotensin II.<\/p>\n\n\n\n

CBD can also affect blood pressure by acting on the endocannabinoid system<\/a>.<\/p>\n\n\n\n

As both these drugs can decrease blood pressure levels in the body, taking them together can cause a rapid decrease in blood pressure<\/strong>. This could cause side effects like dizziness, postural hypotension, fainting, etc.<\/p>\n\n\n\n

<\/a>B. CBD May Slow Down Benazepril Hydrochloride’s Metabolization (Metabolic Competition)<\/h3>\n\n\n\n

Metabolic competition happens when two substances require the same enzymes for metabolism, leading to them competing against each other for the said enzymes. This means taking them together can cause an increased accumulation of one or both drugs.<\/strong><\/p>\n\n\n\n

Most of the angiotensin-converting enzyme inhibitors get partially metabolized in the CYP3A4 system, but they are not very involved in P450 interactions [1<\/a>].<\/p>\n\n\n\n

Benazepril hydrochloride gets converted to its active enzyme benazeprilat in the liver. Like other ACE inhibitors, it may also undergo hepatic metabolism by CYP3A4. However, the precise enzyme that metabolizes it is not known.<\/p>\n\n\n\n

On the other hand, CBD uses the same enzyme for metabolism.<\/p>\n\n\n\n

Hence, using them together may cause metabolic inhibition between them, slowing down their metabolism<\/strong> and how quickly they leave the body, causing an increased risk of adverse effects. While there are very few chances of this happening, it is still possible and should always be taken into account.<\/p>\n\n\n\n

<\/a>Similar Medications: CBD & ACE inhibitors<\/h2>\n\n\n\n

Benazepril hydrochloride is an angiotensin-converting enzyme inhibitor. CBD and ACE inhibitors<\/a> all share similar risks for interaction and side effects since they\u2019re all used to decrease blood pressure levels and congestive heart failure.<\/p>\n\n\n\n

Here’s a list of similar medications that share a similar level of risk when combined with CBD:<\/strong><\/p>\n\n\n\n