{"id":36651,"date":"2022-01-27T12:31:30","date_gmt":"2022-01-27T12:31:30","guid":{"rendered":"https:\/\/dailycbd.com\/en\/?page_id=36651"},"modified":"2022-01-27T12:32:13","modified_gmt":"2022-01-27T12:32:13","slug":"guanfacine","status":"publish","type":"page","link":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/","title":{"rendered":"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?"},"content":{"rendered":"\n<p>Guanfacine hydrochloride belongs to a class of medications called central agonists. It\u2019s used for managing high blood pressure as well as attention deficit hyperactivity disorder (ADHD).<\/p>\n\n\n\n<p>This medication is rarely used today as better options exist \u2014 however, it\u2019s still prescribed when other medications fail to offer support.&nbsp;<\/p>\n\n\n\n<p>Here, we&#8217;ll examine the potential risks of mixing CBD with this older generation hypertension medication and offer some tips on how you can reduce your risk with this combination.&nbsp;<\/p>\n\n\n\n<h2>Does CBD Interact With Guanfacine Hydrochloride (Tenex)?&nbsp;<\/h2>\n\n\n\n<p><strong>Yes. CBD may interact with guanfacine hydrochloride (Tenex).&nbsp;<\/strong><\/p>\n\n\n\n<p>The most concerning side effect of this interaction is low blood pressure, which can cause dizziness, confusion, and fainting.&nbsp;<\/p>\n\n\n\n<p>Overall, the chances these medications will interact is minimal.&nbsp;<\/p>\n\n\n\n<p><strong>CBD can interact with guanfacine in two ways:<\/strong><\/p>\n\n\n\n<h3>A) CBD May Increase the Risk of Side Effects From Tenex<\/h3>\n\n\n\n<p>Guanfacine is a centrally acting alpha 2 adrenergic agonist. It <strong>decreases blood pressure by activating the receptors for alpha 2 adrenoreceptors of the nervous system <\/strong>that leads to a decrease in peripheral sympathetic outflow. This causes a decrease in both the systolic and diastolic pressure.&nbsp;<\/p>\n\n\n\n<p>CBD, on the other hand,<strong> works on <\/strong><a href=\"https:\/\/dailycbd.com\/en\/endocannabinoid-system\/\"><strong>the endocannabinoid system<\/strong><\/a>. One of the effects of CBD is a relaxation of the blood vessels \u2014 leading to a reduction in blood pressure.&nbsp;<\/p>\n\n\n\n<p>Taking these two drugs together may cause <strong>the blood pressure to decrease more than expected and cause side effects like fainting dizziness<\/strong>.&nbsp;<\/p>\n\n\n\n<h3>B) CBD May Interfere With The Metabolism of Tenex<\/h3>\n\n\n\n<p>Metabolic competition occurs when two substances use the same enzymes for metabolism, causing them to compete against each other if consumed together.&nbsp;<\/p>\n\n\n\n<p>Guanfacine is metabolized by the cytochrome enzyme <strong>CYP3A4<\/strong>. <a href=\"https:\/\/dailycbd.com\/en\/cannabinoids\/metabolism\/\">CBD is also metabolized by the 3A4 enzymes<\/a>, along with others such as 2D6 and 2C19.&nbsp;<\/p>\n\n\n\n<p>Because of this overlap, it\u2019s possible that CBD and Tenex will compete with each other for metabolism \u2014 leading to a gradual buildup of both substances over time.<\/p>\n\n\n\n<p>The result could be over-accumulation of guanfacine and a slow removal rate. This could cause several side effects like a rapid decrease in blood pressure, headaches, fainting, etc.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"612\" height=\"408\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil.png\" alt=\"\" class=\"wp-image-36598\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil.png 612w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-300x200.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-180x120.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-283x189.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-54x36.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-330x220.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-420x280.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-74x49.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/holding-cbd-oil-45x30.png 45w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/figure>\n\n\n\n<h2>Similar Medications: CBD &amp; Central Agonists<\/h2>\n\n\n\n<p>Guanfacine is classified as centrally acting alpha 2A-adrenergic receptor agonists or simply<strong> a \u201c<\/strong>central agonist.\u201d&nbsp;<\/p>\n\n\n\n<p><a href=\"https:\/\/dailycbd.com\/en\/drug-interactions\/#h2-cbd-blood-pressure-medications-3\">CBD and central agonists<\/a> all share similar risks for interaction and side effects, with the primary side effect to watch out for revolving around the symptoms of low blood pressure.&nbsp;<\/p>\n\n\n\n<p><strong>Other Central Agonists That May Interact With CBD:&nbsp;<\/strong><\/p>\n\n\n\n<ul><li><strong>Alpha Methyldopa<\/strong> (Aldomet)<\/li><li><strong>Clonidine Hydrochloride<\/strong> (Catapres)<\/li><li><strong>Guanabenz Acetate<\/strong> (Wytensin)<\/li><\/ul>\n\n\n\n<h2>Is It Safe to Take CBD &amp; Guanfacine Hydrochloride (Tenex) Together?<\/h2>\n\n\n\n<p>Taking CBD and Tenex could cause users to feel dizzy or lightheaded. This can become especially dangerous while driving or operating heavy machinery.<\/p>\n\n\n\n<p>Should you decide to take these compounds together, be cautious of the dose and<a href=\"https:\/\/dailycbd.com\/en\/talk-to-your-doctor-cbd\/\"> ask your prescribing physician<\/a> about it before you begin.&nbsp;<\/p>\n\n\n\n<h2>Is CBD A Viable Alternative to Guanfacine Hydrochloride (Tenex)?<\/h2>\n\n\n\n<p><a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/hypertension\/\">CBD has blood pressure-lowering abilities<\/a>, but these effects are very different from the effects of prescription hypertensives like Tenex.&nbsp;<\/p>\n\n\n\n<p>CBD may be a good alternative to Tenex for prehypertension (systolic blood pressure between 120 and 129) as a way to delay or prevent the need for prescription medications.&nbsp;<\/p>\n\n\n\n<p>CBD can decrease blood pressure by working on the CB1 receptors in the endothelium. This action releases nitric oxide, dilating the blood pressure and subsequently decreasing blood pressure [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4540144\/\" target=\"_blank\" rel=\"noreferrer noopener\">1<\/a>].&nbsp;<\/p>\n\n\n\n<p>CBD&#8217;s <a href=\"https:\/\/dailycbd.com\/en\/best-cbd\/inflammation\/\">antioxidative and anti-inflammat<\/a>ory properties can decrease the inflammatory conditions that may be responsible or result from high blood pressure [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7023045\/\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>].&nbsp;<\/p>\n\n\n\n<p>One study showed that CBD is capable of reducing blood pressure in users who also have increased heart rates [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5470879\/\" target=\"_blank\" rel=\"noreferrer noopener\">3<\/a>].&nbsp;<\/p>\n\n\n\n<p>However, if blood pressure is already above 130, CBD isn&#8217;t going to be a viable alternative to prescription medications. The risk of heart attack and stroke increases substantially with high blood pressure and should be treated according to the requests of a medical professional.&nbsp;<\/p>\n\n\n\n<h2>What is Guanfacine Hydrochloride (Tenex)?<\/h2>\n\n\n\n<p>Guanfacine is a centrally acting alpha 2A-adrenergic receptor agonist. It\u2019s used for the treatment of hypertension and ADHD. Tenex is one of its most commonly used brands.&nbsp;<\/p>\n\n\n\n<p>Tenex is FDA-approved and available as a prescription-only medication.<\/p>\n\n\n\n<h3><strong>Guanfacine Hydrochloride (Tenex) Specs:<\/strong><\/h3>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-medium\"><img width=\"300\" height=\"300\" src=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-300x300.png\" alt=\"\" class=\"wp-image-36569\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-300x300.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-150x150.png 150w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-768x768.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-180x180.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-158x158.png 158w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-80x80.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-120x120.png 120w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-70x70.png 70w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-40x40.png 40w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-283x283.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-54x54.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-330x330.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-420x420.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-74x74.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule-30x30.png 30w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-molecule.png 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/figure><\/div>\n\n\n\n<div class=\"t-old\"><figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Drug Name&nbsp;<\/strong><\/td><td>Guanfacine Hydrochloride<\/td><\/tr><tr><td><strong>Trade Name&nbsp;<\/strong><\/td><td>Tenex, Afken, Estulic, Intuniv<\/td><\/tr><tr><td><strong>Classification&nbsp;<\/strong><\/td><td>Central Agonists<\/td><\/tr><tr><td><strong>CYP Metabolism<\/strong><\/td><td>CYP3A4<\/td><\/tr><tr><td><strong>Interaction With CBD<\/strong><\/td><td>Agonistic, Metabolic competition<\/td><\/tr><tr><td><strong>Risk of Interaction&nbsp;<\/strong><\/td><td>Low<\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\n<h3>Other Names For Guanfacine Hydrochloride(Tenex)&nbsp;<\/h3>\n\n\n\n<p>Guanfacine is sold under a few other brand names. All share the same risk and potential interactions.<\/p>\n\n\n\n<p><strong>Other names for guanfacine include:<\/strong><\/p>\n\n\n\n<ul><li>Afken<\/li><li>Estulic<\/li><li>Intuniv<\/li><\/ul>\n\n\n\n<h3>What Does Guanfacine Hydrochloride (Tenex) Do?<\/h3>\n\n\n\n<p>Guanfacine is a centrally acting alpha-2A (\u03b12A) adrenergic receptor agonist, which works by reducing the effects of the sympathetic nervous system on the heart and circulatory system.&nbsp;<\/p>\n\n\n\n<p>Guanfacine acts on the \u03b12A adrenoceptors in the central nervous system. This causes a reduction in the peripheral sympathetic outflow, meaning it causes a decrease in the transmission of the neurotransmitters through the nerves. This leads to a reduction in peripheral sympathetic tone. This will then cause a decrease in both the systolic as well as diastolic blood pressure.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Guanfacine is also used in the treatment of attention deficit hyperactivity disorder (ADHD). It is believed to work by interacting with the prefrontal cortex.&nbsp;<\/p>\n\n\n\n<p>Guanfacine may cause this positive effect on the \u03b12A adrenoceptors on dendritic spines. There will be an inhibition of the cyclic adenosine monophosphate (cAMP )-mediated opening of HCN and KCNQ channels. This may end up enhancing the prefrontal cortical synaptic connectivity as well as neuronal firing and effectively decreasing symptoms of ADHD [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3143019\/\" target=\"_blank\" rel=\"noreferrer noopener\">4<\/a>].&nbsp;<\/p>\n\n\n\n<p>Guanfacine reaches its peak effect at 1 to 4 hours and has a half-life of 17 hours. There are no studies to show its effects on pregnant and lactating women.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img src=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack.png\" alt=\"\" class=\"wp-image-36653\" width=\"600\" height=\"600\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack.png 800w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-300x300.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-150x150.png 150w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-768x768.png 768w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-180x180.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-158x158.png 158w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-80x80.png 80w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-120x120.png 120w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-70x70.png 70w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-40x40.png 40w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-283x283.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-54x54.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-330x330.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-420x420.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-74x74.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/guanfacine-pack-30x30.png 30w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n\n\n\n<h3>Side Effects of Guanfacine Hydrochloride(Tenex)&nbsp;<\/h3>\n\n\n\n<ul><li>Abdominal pain<\/li><li>Alopecia<\/li><li>Anxiety<\/li><li>Asthenia<\/li><li>Bradycardia<\/li><li>Confusion<\/li><li>Constipation<\/li><li>Decreased appetite<\/li><li>Depression<\/li><li>Dermatitis<\/li><li>Diaphoresis<\/li><li>Diarrhea<\/li><li>Dizziness<\/li><li>Dry mouth<\/li><li>Dyspepsia<\/li><li>Dysphagia<\/li><li>Dyspnea<\/li><li>Enuresis<\/li><li>Fatigue<\/li><li>Headache<\/li><li>Hypokinesia<\/li><li>Hypotension<\/li><li>Hypersensitivity<\/li><li>Impotence<\/li><li>Increased weight<\/li><li>Insomnia<\/li><li>Irritability<\/li><li>Leg cramps<\/li><li>Lethargy<\/li><li>Nausea<\/li><li>Nightmare<\/li><li>Palpitations<\/li><li>Postural dizziness<\/li><li>Pruritus<\/li><li>Rash<\/li><li>Somnolence<\/li><li>Weakness<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"612\" height=\"408\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg.png\" alt=\"Cannabis sativa plant over white background\" class=\"wp-image-33791\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg.png 612w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-300x200.png 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-180x120.png 180w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-283x189.png 283w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-54x36.png 54w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-330x220.png 330w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-420x280.png 420w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-74x49.png 74w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/cannabis-plant-8-bg-45x30.png 45w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/figure>\n\n\n\n<h2>Key Takeaways: Is it Safe to Take Guanfacine Hydrochloride (Tenex) With CBD?<\/h2>\n\n\n\n<p><strong>CBD has a mild risk of interacting with guanfacine<\/strong>. Long time usage with a high dose of both drugs could cause some side effects due to overaccumulation and slow removal. However, smaller doses taken for a short time are less likely to do so.&nbsp;&nbsp;<\/p>\n\n\n\n<p><strong>Don&#8217;t take both CBD and guanfacine together without consulting your prescribing physician first<\/strong>. In case of any abnormal side effects, get medical aid immediately.&nbsp;<\/p>\n\n\n\n<p>CBD may be helpful to treat milder forms of hypertension; however, it may be ineffective in case of severe conditions.&nbsp;&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator\" \/>\n\n\n\n<h2>References<\/h2>\n\n\n\n<ol><li>Stanley, C. P., Hind, W. H., Tufarelli, C., &amp; O&#8217;Sullivan, S. E. (2015). Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. <em>Cardiovascular Research<\/em>, <em>107<\/em>(4), 568-578.&nbsp;<\/li><li>&nbsp;Atalay, S., Jarocka-Karpowicz, I., &amp; Skrzydlewska, E. (2020). Antioxidative and anti-inflammatory properties of cannabidiol. <em>Antioxidants<\/em>, <em>9<\/em>(1), 21.&nbsp;<\/li><li>Jadoon, K. A., Tan, G. D., &amp; O&#8217;Sullivan, S. E. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. <em>JCI insight<\/em>, <em>2<\/em>(12).<\/li><li>Arnsten, A. F. (2010). The use of \u03b1-2A adrenergic agonists for the treatment of attention-deficit\/hyperactivity disorder. <em>Expert review of neurotherapeutics<\/em>, <em>10<\/em>(10), 1595-1605.&nbsp;<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Cannabidiol (CBD) and the central agonist guanfacine hydrochloride have a low chance of interacting, but the potential side effects can be severe.<\/p>\n","protected":false},"author":1,"featured_media":36427,"parent":27451,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"categories":[3589],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?<\/title>\n<meta name=\"description\" content=\"Cannabidiol (CBD) and the central agonist guanfacine hydrochloride have a low chance of interacting, but the potential side effects can be severe.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?\" \/>\n<meta property=\"og:description\" content=\"Cannabidiol (CBD) and the central agonist guanfacine hydrochloride have a low chance of interacting, but the potential side effects can be severe.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/\" \/>\n<meta property=\"og:site_name\" content=\"Daily CBD - English\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-27T12:32:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/cbd-guanfacine-cover.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1541\" \/>\n\t<meta property=\"og:image:height\" content=\"833\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dailycbd.com\/en\/#website\",\"url\":\"https:\/\/dailycbd.com\/en\/\",\"name\":\"Daily CBD - English\",\"description\":\"Your Guide in the world of Cannabidiol and Hemp extracts\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dailycbd.com\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#primaryimage\",\"url\":\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/cbd-guanfacine-cover.png\",\"contentUrl\":\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/cbd-guanfacine-cover.png\",\"width\":1541,\"height\":833,\"caption\":\"Illustration of a guanfacine gel capsule\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#webpage\",\"url\":\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/\",\"name\":\"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?\",\"isPartOf\":{\"@id\":\"https:\/\/dailycbd.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#primaryimage\"},\"dateModified\":\"2022-01-27T12:32:13+00:00\",\"description\":\"Cannabidiol (CBD) and the central agonist guanfacine hydrochloride have a low chance of interacting, but the potential side effects can be severe.\",\"breadcrumb\":{\"@id\":\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/dailycbd.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Taking Cannabidiol With Other Medications: CBD-Drug Interaction Checker\",\"item\":\"https:\/\/dailycbd.com\/en\/drug-interactions\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?\"}]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?","description":"Cannabidiol (CBD) and the central agonist guanfacine hydrochloride have a low chance of interacting, but the potential side effects can be severe.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/","og_locale":"en_US","og_type":"article","og_title":"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?","og_description":"Cannabidiol (CBD) and the central agonist guanfacine hydrochloride have a low chance of interacting, but the potential side effects can be severe.","og_url":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/","og_site_name":"Daily CBD - English","article_modified_time":"2022-01-27T12:32:13+00:00","og_image":[{"width":1541,"height":833,"url":"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/cbd-guanfacine-cover.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebSite","@id":"https:\/\/dailycbd.com\/en\/#website","url":"https:\/\/dailycbd.com\/en\/","name":"Daily CBD - English","description":"Your Guide in the world of Cannabidiol and Hemp extracts","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dailycbd.com\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#primaryimage","url":"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/cbd-guanfacine-cover.png","contentUrl":"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2022\/01\/cbd-guanfacine-cover.png","width":1541,"height":833,"caption":"Illustration of a guanfacine gel capsule"},{"@type":"WebPage","@id":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#webpage","url":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/","name":"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?","isPartOf":{"@id":"https:\/\/dailycbd.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#primaryimage"},"dateModified":"2022-01-27T12:32:13+00:00","description":"Cannabidiol (CBD) and the central agonist guanfacine hydrochloride have a low chance of interacting, but the potential side effects can be severe.","breadcrumb":{"@id":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/dailycbd.com\/en\/drug-interactions\/guanfacine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dailycbd.com\/en\/"},{"@type":"ListItem","position":2,"name":"Taking Cannabidiol With Other Medications: CBD-Drug Interaction Checker","item":"https:\/\/dailycbd.com\/en\/drug-interactions\/"},{"@type":"ListItem","position":3,"name":"Is CBD Safe To Take With Guanfacine Hydrochloride (Tenex)?"}]}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/pages\/36651"}],"collection":[{"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/comments?post=36651"}],"version-history":[{"count":5,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/pages\/36651\/revisions"}],"predecessor-version":[{"id":37758,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/pages\/36651\/revisions\/37758"}],"up":[{"embeddable":true,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/pages\/27451"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/media\/36427"}],"wp:attachment":[{"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/media?parent=36651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/categories?post=36651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dailycbd.com\/en\/wp-json\/wp\/v2\/tags?post=36651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}