Risk of Interaction <\/strong><\/td>High<\/td><\/tr><\/tbody><\/table><\/figure><\/div>\n\n\n\nWhat Does Clonazepam (Klonopin) Do?<\/h3>\n\n\n\n Clonazepam’s primary mechanism of action is the modulation of GABA function in the brain. <\/p>\n\n\n\n
It does this by acting on the benzodiazepine receptor located on GABAA receptors. It acts by binding to the benzodiazepine site of the GABA receptors, which enhances the electric effect of GABA binding on neurons. <\/p>\n\n\n\n
Clonazepam doesn’t alter GABA levels directly; rather, it alters the affinity for GABA to bind to existing receptors. <\/p>\n\n\n\n
This action results in an inhibition of synaptic transmission across the central nervous system. This allows clonazepam to perform its anticonvulsant, skeletal muscle relaxant, and anxiolytic effects. <\/p>\n\n\n\n
Clonazepam also decreases the use of 5-HT (serotonin) by neurons.<\/p>\n\n\n\n
Clonazepam is used to treat seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures. It\u2019s also used in treating anxiety, panic disorders, and movement disorders called akathisia. <\/p>\n\n\n\n
What is GABA?<\/h4>\n\n\n\n GABA is one of the principal inhibitory neurotransmitters in the human body. When GABA binds to \u03b3-Aminobutyric acid type A (GABAA) receptors found in neuron synapses, chloride ions get conducted across neuron cell membranes through an ion channel in the receptors. <\/p>\n\n\n\n
When enough chloride ions get conducted, the local neuron membrane potentials get hyperpolarized. This action makes it difficult for action potentials to fire, and thus, it ultimately results in less excitation of the neurons. <\/p>\n\n\n\n
Side Effects of Clonazepam (Klonopin)<\/h3>\n\n\n\n Klonopin comes with a high risk of side effects which range from changes in mood and behavior to lapses in memory. It’s also habit-forming and highly addictive if used for long periods of time. <\/p>\n\n\n\n
Because of its dependency-forming ability, clonazepam, like other benzodiazepines, is used as a first-line treatment for seizures but not for its long-term treatment. Clonazepam has also been associated with recreational use and drug abuse. <\/p>\n\n\n\n
It can also cause withdrawal symptoms if stopped abruptly. The withdrawal symptoms consist of increased anxiety, irritability, insomnia, tremors, headaches, stomach pain, nausea, hallucinations, fatigue, depression, etc. <\/p>\n\n\n\n
Clonazepam must be used with caution in patients with depression as there is an increased risk of suicide. It should be used during pregnancy only if needed and if the benefit outweighs the risk. <\/p>\n\n\n\n
Side effects of clonazepam (Klonopin) include:<\/strong><\/p>\n\n\n\nAggression<\/li> Ataxia<\/li> Coughing <\/li> Decreased libido<\/li> Depression <\/li> Dizziness <\/li> Dysarthria <\/li> Fatigue <\/li> Lack of motivation<\/li> Liver damage<\/li> Memory impairment<\/li> Psychomotor agitation<\/li> Psychosis<\/li> Short term memory loss<\/li> Suicidal ideation<\/li> Upper respiratory infection <\/li> Urinary frequency <\/li> Worsening of seizures<\/li><\/ul>\n\n\n\nOther Names For Clonazepam (Klonopin)<\/h3>\n\n\n\n Clonazepam is sold under many different names. All share the same risk and potential interactions.<\/p>\n\n\n\n
Other names for Clonazepam (Klonopin)<\/strong> include:<\/strong><\/p>\n\n\n\nAlcona <\/li> Anxrea<\/li> Aplaz <\/li> Azepic <\/li> C-Pram-S Plus <\/li> Caryclone <\/li> Catier<\/li> Cita-S Forte <\/li> Clonapam<\/li> Clonapax<\/li> Clonaz<\/li> Clonotril<\/li> Czpam<\/li> Klozep<\/li> Lonazep<\/li> Melzap<\/li> Rivotril<\/li><\/ul>\n\n\n\nKey Takeaways: Is it Safe to Take Clonazepam (Klonopin) With CBD?<\/h2>\n\n\n\n CBD and clonazepam have a moderate to high likelihood of interacting negatively and, therefore, should not be used together.\u00a0<\/strong><\/p>\n\n\n\nBoth substances exert a similar influence on the central nervous system. Taking both together could result in an excessive suppression of neurological activity, leading to side effects. Some of these side effects are severe and could result in injury or death. <\/p>\n\n\n\n
Always speak to your doctor about CBD<\/a> before you mix it with your prescription medications. Your doctor can assess your level of risk and may want to adjust your dose to account for the potential interaction.\u00a0<\/p>\n\n\n\nReferences <\/h2>\n\n\n\nBlessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics<\/em>, 12<\/em>(4), 825-836. <\/li>Lattanzi, S., Brigo, F., Trinka, E., Zaccara, G., Cagnetti, C., Del Giovane, C., & Silvestrini, M. (2018). Efficacy and safety of cannabidiol in epilepsy: a systematic review and meta-analysis. Drugs<\/em>, 78<\/em>(17), 1791-1804. <\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"CBD (cannabidiol) & clonazepam (Klonopin) are both commonly used for alleviating anxiety & insomnia. Are these compounds safe to mix? What are the risks?<\/p>\n","protected":false},"author":1,"featured_media":35455,"parent":27451,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"categories":[3589],"tags":[],"yoast_head":"\n
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