Although few human studies have evaluated the interactions between CBD and amphetamines, some animal studies suggest that CBD may alter the effects of amphetamine while also attenuating the unwanted long-term side effects associated with its use [3<\/a>].<\/p>\n\n\n\n CBD may interact with amphetamine (Adderall) by decreasing its effects, possibly negating its benefits, causing increased symptoms of the condition being treated.<\/p>\n\n\n\n The severity of this interaction is considered mild and unlikely to cause significant side effects. <\/p>\n\n\n\n In some cases, this effect could be viewed as a positive, as many of the effects of amphetamines CBD inhibits are considered side effects of using the medication (such as insomnia, anxiety, paranoia, and addiction). <\/p>\n\n\n\n With that said, CBD could make amphetamines ineffective for treating ADHD, which would negate the entire point of using the medication in the first place.<\/p>\n\n\n\n The cannabinoid receptors CB1 and CB2 are distributed throughout the body in areas like the brain, organs, connective tissue, endocrine glands, and the immune system.<\/p>\n\n\n\n CBD acts through these receptors as a negative allosteric modulator. CBD also modulates neural circuits such as the dopaminergic mesocorticolimbic system, which is involved in addiction and drug-seeking behaviors [3].<\/p>\n\n\n\n Amphetamine (Adderall), on the other hand, is a psychostimulant drug. It increases the excitatory neurotransmitters \u2014 dopamine and norepinephrine \u2014 and causes wakefulness, euphoria, increased libido, and a better attention span.<\/p>\n\n\n\n CBD may induce molecular modifications in the dopaminergic pathways via a secondary response mechanism to its effects on the endocannabinoid system<\/a>. This modification, in turn, may attenuate the effects of amphetamine, which chiefly exerts its effects through the neurotransmitter dopamine.<\/p>\n\n\n\n CBD may also interfere with the metabolism of amphetamine (Adderall). <\/p>\n\n\n\n Most medications, as well as CBD, are metabolized by the liver before they\u2019re eliminated from the body. CBD competes for the same enzymes involved with metabolizing amphetamines, which can cause the processing of both substances to become slower. This may lead to elevations in both CBD and amphetamines in the bloodstream with repeated use. <\/p>\n\n\n\n CYP2D6 is a major liver enzyme involved in the metabolism of both CBD and amphetamine. CBD acts as a competitive inhibitor of the enzyme CYP2D6 leading to decreased metabolism of the amphetamine and increased concentration of the drug in the body [4<\/a>].<\/p>\n\n\n\n This mechanism is relevant when amphetamine is taken in high doses with CBD. It may cause increased heart rate, arrhythmia, confusion, agitation, tremors, and muscle pain.<\/p>\n\n\n\n Amphetamine is sold under many names, all of which share the same risk and potential interactions.<\/p>\n\n\n\n The most common brand name amphetamine is sold under is Adderall \u2014 which is made by Teva Pharmaceuticals. <\/p>\n\n\n\n Other names for amphetamine include:<\/strong><\/p>\n\n\n\n Amphetamine (Adderall) is classified as a nervous system stimulant. CBD and stimulants<\/a> all share the same risk for interaction and side effects.<\/p>\n\n\n\n Here\u2019s a list of similar medications that share a similar level of risk when combined with CBD:<\/strong><\/p>\n\n\n\n CBD and amphetamine (Adderall) are generally safe at a low therapeutic dose but can be hazardous when used in high doses for recreational use (not recommended). It could also become dangerous over time if both substances are taken together on a regular basis. <\/p>\n\n\n\n You should, however, always consult your doctor if you\u2019re on any medication before adding any other drug \u2014 even a natural one \u2014 to avoid possible interactions.<\/p>\n\n\n\n A few clinical trials show evidence of some benefits of using CBD for ADHD<\/a> and its comorbidities, but the improvements were not significant enough for CBD to be an alternative to amphetamine [5<\/a>].<\/p>\n\n\n\n These substances share very little in common and are not suitable as alternatives for one another. <\/p>\n\n\n\n Amphetamine (Adderall) is a central nervous system (CNS) stimulant that increases the release of excitatory neurotransmitters dopamine and norepinephrine from the presynaptic terminals.<\/p>\n\n\n\n Amphetamine is prescribed for ADHD and increases attention span and focus, and helps control behavior problems. It may also help with organization and listening skills. It\u2019s illegal to use amphetamine for recreational purposes.<\/p>\n\n\n\n Amphetamine is available in three forms:<\/strong><\/p>\n\n\n\n1. CBD May Decrease The Effects of Amphetamine (Antagonistic Interaction)<\/h3>\n\n\n\n
How This Interaction Works<\/h4>\n\n\n\n
2. CBD May Cause Slower Elimination (Metabolic Competition)<\/h3>\n\n\n\n
How This Interaction Works<\/h4>\n\n\n\n
Other Names for Amphetamine<\/h2>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/dyanavel-xr.png\")
<\/figure><\/div>\n\n\n\nSimilar Medications: CBD & Amphetamine (Adderall)<\/h2>\n\n\n\n
Is It Safe to Take CBD & Amphetamine (Adderall) Together?<\/h2>\n\n\n\n
Is CBD a Viable Alternative to Amphetamine (Adderall)?<\/h2>\n\n\n\n
What Is Amphetamine (Adderall)?<\/h2>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/10\/amphetamine-molecule-300x300.png\")
<\/figure><\/div>\n\n\n\nAmphetamine specs:<\/h3>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2021\/07\/cbd-oil-1131.png\")
<\/figure><\/div>\n\n\n\n