Cannabinoids such as CBD interact with this system to improve its ability to control processes such as dopamine production, nerve regeneration, inflammation, glutamate function, and immune cell activity in the brain \u2014 all of which are important factors involved with prion disease.<\/p>\n\n\n\n
There are some aspects of CBD and other cannabinoids that suggest their use for prion disease, and preliminary research is showing promise. <\/p>\n\n\n\n
However, this research is far from conclusive. We haven\u2019t proven that it can or can\u2019t treat prion disease yet.<\/strong><\/p>\n\n\n\n As the research improves over the next couple of years, we\u2019ll be sure to keep you updated on any breaking news.<\/p>\n\n\n\n The potential benefits of CBD for prion disease include: <\/strong><\/p>\n\n\n\n Prions are unusual disease-causing agents \u2014 they\u2019re not bacterial, viral, or parasitic. They\u2019re not alive \u2014 and there\u2019s no good explanation as of yet for why they exist.<\/p>\n\n\n\n A prion is a protein. The word is derived from the proteinaceous infectious particle. <\/em>Prion proteins are naturally occurring throughout the brain (PrPc<\/sup>), but their function isn\u2019t well understood. Normally, these proteins are water-soluble and are broken down by enzymes known as proteases in the brain.<\/p>\n\n\n\n Diseased prions can make their way into the brain where they self-replicate by converting healthy prions into diseased ones.<\/p>\n\n\n\n These new proteins are resistant to protease, so cannot be broken down in the brain. When this happens, we start to develop \u201cbroken\u201d proteins in the brain that we can’t get rid of. These proteins crowd areas of the brain, and since they have nothing to offer, the brain starts to decay over time.<\/p>\n\n\n\n It can take many years to begin showing symptoms.<\/p>\n\n\n\n Initial research on prion disease discovered that the infectious agents responsible were lacking a nucleic acid genome \u2014 all previously infectious agents, including bacteria and viruses, used nucleic acids to replicate themselves. <\/p>\n\n\n\n Since prions don\u2019t have these, it wasn\u2019t clear how they were able to reproduce themselves in the brain.<\/p>\n\n\n\n It wasn\u2019t until later that researchers discovered that prion diseases were caused by misshapen proteins, which would bind to other proteins and cause them to change shape as well. Prions spark a chain reaction of converting healthy proteins to unhealthy proteins that gradually spread throughout the brain \u2014 eventually leading to extensive, irreversible damage.<\/p>\n\n\n\n Before the 1950s, we had no idea what caused neurodegenerative disorders such as Creutzfeldt-Jakob Disease (CJD or “mad cow disease”).<\/p>\n\n\n\n Incidences were random, and disease progression was mysterious \u2014 leading researchers down dead ends with every attempt to understand the condition.<\/p>\n\n\n\n Sometime in the 1950s, everything changed. Researchers identified a disease among the Fore tribe in Papua New Guinea with symptoms very similar to CJD. It was identified that the disease was transmitted during a funeral ritual practiced by the tribe involving cannibalism of the brains of deceased tribe members. <\/p>\n\n\n\n Researchers noticed that some of the tribe members that were deceased had extensive brain damage (encephalopathy). Extracts made from brain samples were injected into monkeys \u2014 resulting in very similar symptoms. It was at this point that prion disease was discovered to spread through the ingestion of infected brain matter.<\/p>\n\n\n\n Other, more complex interactions may be involved as well, such as co-infection with a virus that interacts with the protein symbiotically (called the virino hypothesis<\/em>), but this theory has contradictions and requires more research.<\/p>\n\n\n\n The cause and progression of prion disease are still heavily debated in the medical community, but it\u2019s been rapidly progressing over the past five decades.<\/p>\n\n\n\n It\u2019s now believed that prion disease starts through random mutation, which may or may not be passed on genetically. If prions from the brain get into another member of the same species, they can become infectious, propagating in the brain of those infected with the protein.<\/p>\n\n\n\n Prion disease usually begins after eating food contaminated with the misshapen protein. In the bloodstream, the prion doesn\u2019t pose much threat to the body, and in most cases, the body can get rid of them safely.<\/p>\n\n\n\n However, in some cases, these prions end up in places such as the spleen, peripheral neurons, or the brain, where they can cause serious long-term problems.<\/p>\n\n\n\n Ultimately, as the misshapen proteins self-replicate and spread through the brain, they kill the neurons, leaving large holes in the brain and making it look like a sponge. The scientific name for this is spongiform encephalopathy.<\/em> For this reason, most prions are considered transmissible spongiform<\/em><\/strong> encephalopathies (TSEs).<\/p>\n\n\n\n There are a few other neurological conditions driven by misshapen proteins in the brain: <\/strong><\/p>\n\n\n\n Interestingly, CBD has been shown to slow the progression of several of these neurological conditions<\/a>.<\/p>\n\n\n\n Misfolded proteins in the brain are devastating in the long term, leading to gradual neurological deficits, loss of muscle control, and death.<\/p>\n\n\n\n Prion disease is a contractible, incurable<\/strong>, degenerative disease. We have drugs to manage symptoms, but currently, nothing that can cure the condition.<\/p>\n\n\n\n However, there are some anti-prion drugs in the pipeline [<\/strong>6<\/strong><\/a>]:<\/strong><\/p>\n\n\n\n CBD can slow the progression of the disease and increase the lifespan of those affected by about 6% [3<\/a>].<\/p>\n\n\n\n Suggested Reading: Is CBD Oil Safe to Use With My Medication?<\/a><\/strong><\/p>\n\n\n\n There are almost no current studies specifically investigating the effects of CBD on prion disease. <\/strong>So far, we\u2019ve only found one promising study on the connection between them. <\/p>\n\n\n\n The study in question involved giving CBD to mice infected with prion disease to see how it affected their lifespan. The mice given CBD in high doses \u2014 after being infected with prion disease \u2014 had a 6% delay in death from the condition compared with the control group [3<\/a>].<\/p>\n\n\n\n Researchers in this study noted that CBD prevented the accumulation of a protein known as PrPres \u2014 the hallmark sign of prion disease. They concluded that CBD could be used to increase the survival of those affected with the disorder.<\/p>\n\n\n\n However, there were some problems with this study, as pointed out by another prominent researcher<\/a>.<\/p>\n\n\n\n The mice who showed improvement with CBD use were given high doses of CBD immediately following infection. This isn\u2019t possible when prion disease in humans isn\u2019t diagnosed until the late stages of the condition. By the usual stage of human diagnosis, CBD application is too late.<\/p>\n\n\n\n Another problem with this study was how the mice were infected. In the study, they were injected with the disease. This changes how the infection works in the body.<\/p>\n\n\n\n Because this disease infects the brain, a prion circulating elsewhere in the body is considered pre-infectious and will behave differently than a prion infection within the brain. Prion research reports that the body develops specific antibodies to protect itself against prions that make their way into the bloodstream [5<\/a>].<\/p>\n\n\n\n In this study, only mice receiving high doses of CBD showed any benefit.<\/p>\n\n\n\n The effective dose used in the study was 60 mg per kg for 12 weeks. This would equate to a dose of around 4800 mg for the average male user (80 kg).<\/p>\n\n\n\n That\u2019s 240 mL of a 600 mg CBD oil \u2014 an unreasonable amount by all standards. That\u2019s about eight standard 30 mL bottles of CBD oil per dose. <\/strong><\/p>\n\n\n\n Even if you used a CBD isolate, you’d need at least 4800 mg to match the amount used in the study \u2014 which costs around $1300 per dose. You would need this dose every day for the rest of your life since there\u2019s no cure for prion disease currently.<\/p>\n\n\n\n Unfortunately, prion disease remains a mystery, and there\u2019s limited research on effective treatment options for the condition. There’s only one study to date highlighting the potential role CBD may play in the progression of the disease.<\/p>\n\n\n\n However, CBD can slow the progression of other non-prion protein folding diseases such as Alzheimer\u2019s disease [9<\/a>], Parkinson\u2019s disease [10<\/a>], and Huntington\u2019s disease [11].<\/p>\n\n\n\n The benefits of CBD come from its protective role on the neurons, lowering neuroinflammation and oxidative damage \u2014 two of the primary causes of destruction resulting from prion disease.<\/p>\n\n\n\n![\"\"](\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2019\/11\/cbd-mad-cow-prion-disease.jpg\")
<\/figure><\/div>\n\n\n\nWhat is Prion Disease?<\/h2>\n\n\n\n
How Does Prion Disease Work?<\/h3>\n\n\n\n
Where Do Prions Come From? <\/h3>\n\n\n\n
![\"\"](\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-prion-disease-2.jpg\")
<\/figure><\/div>\n\n\n\nThe Dangers of Prion Disease<\/h3>\n\n\n\n
Side Effects of Prion Disease<\/h3>\n\n\n\n
List of Known Human Prion Diseases<\/h3>\n\n\n\n
![\"\"](\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-prion-disease-3.jpg\")
<\/figure><\/div>\n\n\n\nIs There a Cure for Prion Disease?<\/h2>\n\n\n\n
There’s Limited Evidence To Support The Effects of CBD For Prion Disease<\/h2>\n\n\n\n
Issues With Prion Research<\/h3>\n\n\n\n
1. Timing of Treatment<\/h4>\n\n\n\n
2. Mode of Prion Infection<\/h4>\n\n\n\n
3. The dose of CBD Treatment<\/h4>\n\n\n\n
Final Verdict: Using CBD for Prion Disease<\/h2>\n\n\n\n
CBD is also useful for managing many of the side-effects of prion diseases, including:<\/h4>\n\n\n\n