{"id":255,"date":"2019-11-22T08:28:00","date_gmt":"2019-11-22T08:28:00","guid":{"rendered":"http:\/\/dailycbd.com\/english\/?post_type=crb_condition&#038;p=255"},"modified":"2021-06-05T23:33:29","modified_gmt":"2021-06-05T23:33:29","slug":"parkinsons-disease","status":"publish","type":"crb_condition","link":"https:\/\/dailycbd.com\/en\/best-cbd\/parkinsons-disease\/","title":{"rendered":"Parkinson\u2019s Disease"},"content":{"rendered":"\n<h2>What Are The Benefits Of CBD For Parkinson\u2019s Disease?<\/h2>\n\n\n\n<p><strong>There is no cure for Parkinson\u2019s disease \u2014 <\/strong>treatment is aimed at slowing the progression of the disease and managing uncomfortable symptoms as they appear in order to improve quality of life. <\/p>\n\n\n\n<p>Parkinson\u2019s patients use CBD supplements to help alleviate symptoms such as depression, anxiety, muscle tremors, and some of the other complications associated with the condition. <\/p>\n\n\n\n<p>There\u2019s also some indication that CBD can be used to slow the progression of the disease and improve underlying factors including brain inflammation and dopamine regulation.<\/p>\n\n\n\n<p><strong>The potential benefits CBD oil for Parkinson\u2019s Disease Include:<\/strong><\/p>\n\n\n\n<ul><li><strong>Reduces brain inflammation<\/strong><\/li><li><strong>Alleviates muscle tremors<\/strong><\/li><li><strong>Supports depression &amp; mood disorders<\/strong><\/li><li><strong>Improves sleep quality &amp; duration<\/strong><\/li><li><strong>May support dopamine production<\/strong><\/li><li><strong>Supports healthy microbiome diversity<\/strong><\/li><\/ul>\n\n\n\n<h3>1. Reduces Brain Inflammation<\/h3>\n\n\n\n<p>Inflammation in the brain is closely associated with Parkinson\u2019s disease [<a href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.519.7264&amp;rep=rep1&amp;type=pdf\">6<\/a>]. As damage occurs in the dopamine-producing neurons in the brain, inflammation gradually worsens. As inflammation intensifies, it speeds up the neurodegenerative processes in the brain \u2014 aggravating the condition.<\/p>\n\n\n\n<p>Inflammation may or may not be an underlying cause for Parkinson\u2019s, we still don\u2019t know for sure. What we do know, however, is that this form of inflammation isn\u2019t making the condition any better. Therefore one of the primary treatments for this condition is to try and <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/inflammation\/\">lower inflammation<\/a> in the brain. This helps the neurons recover, and may slow the progression of the disorder.<\/p>\n\n\n\n<p>CBD is especially proficient at addressing inflammation in the brain as it mediates several key pathways involved with the inflammatory process [<a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0707458\">7<\/a>].<\/p>\n\n\n\n<p>Inflammation in the brain is thought to be one of the main perpetuating factors of Parkinson\u2019s disease [<a href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.519.7264&amp;rep=rep1&amp;type=pdf\">6<\/a>].<\/p>\n\n\n\n<h3>2. May Reduce Muscle Tremors<\/h3>\n\n\n\n<p>Muscle tremors are one of the primary symptoms of Parkinson\u2019s disease. It has a major impact on the quality of life of those affected.<\/p>\n\n\n\n<p>CBD has shown promise in early research to variably improve muscle tremors in mice with Parkinson\u2019s disease [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4357541\/\">8<\/a>], and similar potential neurodegenerative disorders like <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/multiple-sclerosis\/\">multiple sclerosis (MS)<\/a> [9], and <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/huntingtons-disease\/\">Huntington\u2019s disease<\/a> [10]  \u2014 all worth further clinical investigation.<\/p>\n\n\n\n<h3>3. May Alleviate Depression<\/h3>\n\n\n\n<p>Studies suggest that 45% of people with Parkinson\u2019s disease also suffer from <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/anxiety-depression\/\">depression<\/a> [2, 3].<\/p>\n\n\n\n<p>One of the most important benefits of CBD is in the potential relief of depression. The main mechanism CBD is thought to relieve symptoms of depression is through its ability to reduce neuroinflammation [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26996176\">17<\/a>] \u2014 a condition that\u2019s also present with many Parkinson\u2019s disease patients and is likely a contributor to so many Parkinson\u2019s patients also suffer from depression.<\/p>\n\n\n\n<h3>4. Improves Sleep Quality and Onset<\/h3>\n\n\n\n<p>Sleep disorders are a common side-effect of Parkinson\u2019s disease [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4001216\/\">13<\/a>].<\/p>\n\n\n\n<p><strong>There are several reasons for this, including:<\/strong><\/p>\n\n\n\n<ul><li><strong>Involuntary muscle movements sleeping<\/strong><\/li><li><strong>Muscle contractions in the early hours of the morning<\/strong><\/li><li><strong><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/muscle-recovery\/\">Painful cramps at night<\/a><\/strong><\/li><li><strong>Tremor and difficulty turning in bed<\/strong><\/li><li><strong>Medication side-effects <\/strong>(such as levodopa, other dopamine agonists and antidepressants)<\/li><li><strong>Hallucinations<\/strong><\/li><li><strong>Vivid dreams<\/strong><\/li><\/ul>\n\n\n\n<p>CBD is well-known for its mild sedative benefits [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6161644\/\">11<\/a>]. CBD improves both <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/sleep\/\">sleep quality and quantity<\/a> in a series of clinical trials [12].<\/p>\n\n\n\n<p>Other cannabinoids, including <a href=\"http:\/\/dailycbd.com\/en\/cbg\/\">CBG (cannabigerol)<\/a>, are thought to offer muscle relaxant properties \u2014 adding layers of support for some of the primary causes of insomnia among Parkinson\u2019s disease [14].<\/p>\n\n\n\n<h3>5. Supports Dopamine Production<\/h3>\n\n\n\n<p>The primary cause of symptoms with Parkinson\u2019s disease is low dopamine production in the brain. Therefore, one of the most important targets of effective treatment is on the dopamine-producing neurons in the brain.<\/p>\n\n\n\n<p>CBD has been shown \u2014 in at least one preclinical study \u2014 to improve dopamine production [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6093286\/\">15<\/a>]. It works through a newly discovered receptor known as the GPR6 receptors located in the same region where dopamine is manufactured [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X17310744\">16<\/a>].<\/p>\n\n\n\n<p>This is a new and very important discovery. New research is currently underway to understand these effects in more detail and better discern the role CBD could possibly play in the role of Parkinson\u2019s management.<\/p>\n\n\n\n<p>If these findings are shown to be therapeutically relevant through future research, we can expect to see CBD become a primary treatment option for Parkinson&#8217;s disease. At this point, the research is inconclusive.<\/p>\n\n\n\n<h2>What&#8217;s the Recommended Dose of CBD?<\/h2>\n\n\n\n<p>There aren\u2019t enough clinical studies to highlight a specific dosage range for Parkinson&#8217;s disease. However, there&#8217;s a lot of research on the use of CBD use for other neurodegenerative diseases, such as multiple sclerosis.<\/p>\n\n\n\n<p>Heavy doses of CBD are usually required to produce benefits for these conditions.<\/p>\n\n\n\n<p>We recommend starting at the low-strength dose as highlighted in the chart below and build up over time to the heavy dose based on your weight. To find your dose, use the <a href=\"http:\/\/dailycbd.com\/en\/cbd-dosage\/\">CBD oil dosage calculator<\/a> below.<\/p>\n\n\n\n<p>For Parkinson&#8217;s disease, you should aim to use the supplement long-term.<\/p>\n\n\n\n<p><strong>Recommended Strength For Parkinson\u2019s Disease: <\/strong>Heavy Strength<\/p>\n\n\n\n<h3 class=\"has-text-align-center\">CBD Oil Dosage Calculator<\/h3>\n\n\n\n    <div>\n        <div class=\"calc-wr\">\n            <form method=\"post\">\n                <div class=\"calc\" id=\"calculator-478\">\n                    <div class=\"calc--r calc--r-weight\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-weight\"><\/span>Your Weight<\/div>\n                        <div class=\"input-wr\">\n                            <span id=\"weight-sl--vl\"><\/span>\n                            <input type=\"number\" name=\"weight\" value=\"\" min=\"0\" tabindex=\"0\"\/>\n                        <\/div>\n                        <div class=\"calc--u-tabs\">\n                            <input type=\"radio\" id=\"unit-lb\" name=\"unit\" value=\"lb\" class=\"u-t--i\" checked><label for=\"unit-lb\" class=\"u-t--l first\" tabindex=\"1\">lb<\/label>\n                            <input type=\"radio\" id=\"unit-kg\" name=\"unit\" value=\"kg\" class=\"u-t--i\"><label for=\"unit-kg\" class=\"u-t--l\" tabindex=\"2\">kg<\/label>\n                        <\/div>\n                        <div\n                                id=\"weight-slider\"\n                                data-range=\"max\"\n                                data-min=\"0\"\n                                data-max=\"440\"\n                                data-step=\"1\"\n                                data-value=\"\"\n                                data-type=\"\"\n                                class=\"calc--sl\">\n                        <\/div>\n                    <\/div>\n                    <div class=\"calc--r calc--r-strength\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-strength\"><\/span>Desired Strength<\/div>\n                        <div class=\"calc--radio-str\">\n                            <input type=\"radio\" id=\"strength-mild\" name=\"strength\" value=\"mild\" class=\"radio-str--i\"><label for=\"strength-mild\" class=\"radio-str--l first\" tabindex=\"3\">Mild\n                                <span class=\"lb-tooltip\">Mild Dose (General Health, Nausea)<\/span><\/label>\n                            <input type=\"radio\" id=\"strength-moderate\" name=\"strength\" value=\"moderate\" class=\"radio-str--i\"><label for=\"strength-moderate\" class=\"radio-str--l second\" tabindex=\"4\">Moderate\n                                <span class=\"lb-tooltip\">Moderate Dose (Nausea, Pain, Inflammation, Mild Insomnia, Mild Anxiety, Headaches)<\/span><\/label>\n                            <input type=\"radio\" id=\"strength-heavy\" name=\"strength\" value=\"heavy\" class=\"radio-str--i\"><label for=\"strength-heavy\" class=\"radio-str--l\" tabindex=\"5\">Heavy\n                                <span class=\"lb-tooltip\">Heavy Dose (Chronic pain, Inflammation, Insomnia, Anxiety, Migraines, Epilepsy)<\/span><\/label>\n                        <\/div>\n                    <\/div>\n                    <div class=\"calc--r calc--r-totalcbd\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-totalcbd\"><\/span>Total CBD (optional)<span class=\"ask-tooltip\"><\/span><span class=\"lb-tooltip\">How much CBD is in the bottle (found on the label)?<\/span><\/div>\n                        <div class=\"input-wr\">\n                            <input type=\"number\" name=\"totalcbd\" value=\"\" class=\"input-wr--i\" placeholder=\"500\" tabindex=\"6\">\n                            <span class=\"input-wr--u\">mg<\/span>\n                        <\/div>\n                    <\/div>\n                    <div class=\"calc--r calc--r-volume\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-volume\"><\/span>Volume (optional)<span class=\"ask-tooltip\"><\/span><span class=\"lb-tooltip\">How big is your bottle of CBD?<\/span><\/div>\n                        <div class=\"select-wr\">\n                            <select name=\"volume\" id=\"volume-select\" tabindex=\"7s\">\n                                <option selected value>&#8212;<\/option>\n                                <option value=\"15\">15 mL (0.5 oz)<\/option>\n                                <option value=\"30\">30 mL (1 oz)<\/option>\n                                <option value=\"50\">50 mL (1.7 oz)<\/option>\n                                <option value=\"60\">60 mL (2 oz)<\/option>\n                                <option value=\"120\">120 mL (4 oz)<\/option>\n                            <\/select>\n                        <\/div>\n                    <\/div>\n<!--                    <div><input type=\"hidden\" name=\"br\" data-id=\"--><!--\"><\/div>-->\n                <\/div>\n                <div class=\"calc-br\">\n                    <span class=\"powered\">Powered by<\/span><a href=\"https:\/\/dailycbd.com\" class=\"logo\"><img src=\"https:\/\/dailycbd.com\/en\/wp-content\/themes\/dailycbd\/resources\/images\/temp\/daily_logo.svg\" alt=\"DailyCBD\"><\/a>\n                <\/div>\n                <div class=\"calc-actions\">\n                    <div class=\"b-reset\">\n                        <span class=\"reset-icon\"><\/span><input type=\"reset\" id=\"calc-rs\" name=\"reset\" value=\"Reset Form\">\n                    <\/div>\n                    <div class=\"b-submit\">\n                        <a href=\"\" id=\"calc-sb\" class=\"b b--large b--orange calc-sb\"><span>Calculate<\/span><\/a>\n                    <\/div>\n                <\/div>\n            <\/form>\n            <!--    Embed-->\n            <div class=\"embed-wr\"><a href=\"\" class=\"b b--large b--light embed-btn\"><span>Get this calculator<\/span><\/a><\/div>\n            <div class=\"cta-overlay\">\n                <div class=\"cta-modal\">\n                    <div class=\"close-btn\"><\/div>\n                    <div class=\"text-box\">\n                        <p class=\"lead\">Embed this map on your site<\/p>\n                        <p class=\"tagline\">Copy and paste the code below<\/p>\n                    <\/div>\n                    <form>\n                        <textarea id=\"embed\" readonly><script type=\"text\/javascript\">document.write('<iframe src=\"https:\/\/qqbb.click\/c\/d-c\" style=\"border:0;min-height:600px;height:100%;left:0;position:absolute;top:0;width:100%\"><\/iframe>');<\/script><br \/><\/textarea>\n                        <button type=\"button\" value=\"copy\" class=\"b b--large copytoken button\">Copy\n                        <\/button>\n                        <div class=\"cta-tooltip\"><p class=\"cta-tooltip-title\">Successfully copied to clipboard!<\/p>\n                            <p class=\"cta-tooltip-text\">Include this code unmodified to your website to display the calculator.\n                                The widget will appear exactly where you insert the code.\n                                Copy the code, and paste it into your site\\&#8217;s HTML code.<\/p>\n                        <\/div>\n                    <\/form>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n    \n        <script type=\"text\/javascript\">\nwindow.addEventListener('DOMContentLoaded', function() {\n            jQuery(document).ready(function($) {\n                $(this).Calculator(478, false);\n            });\n            });\n\n        <\/script>\n\n    \n\n\n\n<h2>What is Parkinson\u2019s Disease (PD)?<\/h2>\n\n\n\n<p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder affecting the part of the brain responsible for manufacturing dopamine. Dopamine is a neurotransmitter associated with things such as mood, hormone balance, motor function, and focus or attention.<\/p>\n\n\n\n<p><strong>Symptoms of this condition usually appear gradually over the course of several years before and after diagnosis. <\/strong><\/p>\n\n\n\n<p>They begin with nonspecific issues like hyposmia (reduced sense of smell), sleep disorders, constipation, and obesity up to 20 years before the more characteristic muscular issues such as rigidity, tremors, and falling. <\/p>\n\n\n\n<p>As the disease progresses, non-motor symptoms such as hallucinations, delusions, dementia, and depression can appear and worsen over the next 20 years.<\/p>\n\n\n\n<p>Parkinson\u2019s disease by itself isn\u2019t considered fatal \u2014 however, some of the complications brought on by the disease are \u2014 and can also certainly be life-altering and devastating for patients and families.<\/p>\n\n\n\n<p>A common finding in PD patients is an abundance of <em>Lewy bodies<\/em> \u2014 clusters of proteins inside the neurons that don\u2019t break down as they should through normal enzyme reactions in the brain.<\/p>\n\n\n\n<p>As these Lewy bodies become more abundant and build up, they kill the neurons. This type of neuron injury is also characteristic of other neurodegenerative disorders including <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/alzheimers-disease\/\" target=\"_blank\" rel=\"noreferrer noopener\">Alzheimer\u2019s disease (AD)<\/a>. The main differences are in the <em>composition <\/em>and <em>location <\/em>of the proteins.<\/p>\n\n\n\n<p>In the case of Parkinson\u2019s, the majority of these protein clusters are in the basal ganglia of the brainstem \u2014 specifically in the substantia nigra pars compacta neurons.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1000\" height=\"667\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-2.jpg\" alt=\"\" class=\"wp-image-1445\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-2.jpg 1000w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-2-300x200.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-2-768x512.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<h3>What Are The Signs &amp; Symptoms of Parkinson\u2019s Disease?<\/h3>\n\n\n\n<ol><li><strong>Muscle tremors<\/strong><\/li><li><strong>Bradykinesia<\/strong><\/li><li><strong>Limb rigidity<\/strong><\/li><li><strong>Mask-like face<\/strong><\/li><li><strong>Gait and balance problems, i.e. shuffling<\/strong><\/li><li><strong>Depression<\/strong><\/li><li><strong>Poor focus or concentration<\/strong><\/li><li><strong>Mood changes<\/strong><\/li><li><strong>Apathy<\/strong><\/li><li><strong>Constipation<\/strong><\/li><li><strong>Excess salivation<\/strong><\/li><li><strong>Urinary retention<\/strong><\/li><li><strong>Sleep behavior disorders<\/strong><\/li><li><strong>Loss of sense of smell<\/strong><\/li><li><strong>Cognitive impairment<\/strong><\/li><\/ol>\n\n\n\n<h3>Dopamine &amp; Parkinson\u2019s Disease<\/h3>\n\n\n\n<p><strong>The majority of symptoms associated with Parkinson&#8217;s disease result from a loss of dopamine-producing cells in the brainstem. <\/strong><\/p>\n\n\n\n<p>As the dopamine-producing neurons in the brainstem are lost, it becomes more difficult to manufacture the dopamine the brain needs to function properly.  In fact, by the time characteristic muscle symptoms are clinically apparent, over 80% of the dopamine-producing neurons are gone. Without enough dopamine, symptoms like muscle tremors, lockjaw, weakness in the arms and legs, and poor balance are more frequent.<\/p>\n\n\n\n<p><strong>A loss of dopamine is linked with symptoms including:<\/strong><\/p>\n\n\n\n<ul><li><strong>Mood changes<\/strong><\/li><li><strong>Loss of normal muscle control<\/strong><\/li><li><strong>Hormonal changes<\/strong><\/li><li><strong>Poor libido<\/strong><\/li><li><strong>Difficulty concentrating<\/strong><\/li><li><strong>Depression<\/strong><\/li><\/ul>\n\n\n\n<h3>Norepinephrine &amp; Parkinson\u2019s Disease<\/h3>\n\n\n\n<p> Norepinephrine and epinephrine is structurally similar to dopamine and is built through the same pathway as dopamine. Therefore, epinephrine levels also suffer a decrease in production from Parkinson\u2019s disease [<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnsys.2011.00031\/full\">1<\/a>].<\/p>\n\n\n\n<p>These neurotransmitters are major players in the sympathetic nervous system. As they start to become less abundant in the brain and blood vessels, we lose the ability to regulate autonomic functions including heart rate and blood pressure.<\/p>\n\n\n\n<p><strong>A loss of norepinephrine and\/or epinephrine are linked with symptoms including:<\/strong><\/p>\n\n\n\n<ul><li><strong>Fatigue<\/strong><\/li><li><strong><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/hypertension\/\">Changes in blood pressure<\/a><\/strong><\/li><li><strong>Problems with digestion<\/strong><\/li><li><strong>Poor concentration<\/strong><\/li><li><strong>Depression<\/strong><\/li><\/ul>\n\n\n\n<h3>What Causes Parkinson\u2019s Disease?<\/h3>\n\n\n\n<p>The cause for Parkinson\u2019s disease is still unknown \u2014 however, there are a few factors that we now know contribute to the condition over time.<\/p>\n\n\n\n<p>Older studies used to report Parkinson\u2019s disease as being non-hereditary \u2014 meaning a disease that isn\u2019t passed on through genes [<a href=\"https:\/\/books.google.ca\/books?hl=en&amp;lr=&amp;id=0XijYbEuoQcC&amp;oi=fnd&amp;pg=PR13&amp;dq=Jankovic,+J.,+%26+Tolosa,+E.+(Eds.).+(2007).+Parkinson%E2%80%99s+disease+and+movement+disorders.+Lippincott+Williams+%26+Wilkins.%0A&amp;ots=EccpfY9tyl&amp;sig=x9B7RuIo24xC0PsH6GFXYJLCAA4&amp;redir_esc=y\">4<\/a>]. Newer studies, however, found at least two gene variants related to Parkinson\u2019s disease [<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc055509\">5<\/a>] \u2014 LRRK2 and GBA genes, albeit rarely. Most cases by far are idiopathic. <\/p>\n\n\n\n<p><strong>Some factors believed to be linked with Parkinson\u2019s disease include:<\/strong><\/p>\n\n\n\n<ol><li><strong>Heavy metal exposure<\/strong><\/li><li><strong>Traumatic head injuries<\/strong><\/li><li><strong>Genetic factors<\/strong><\/li><li><strong>Paraquat exposure <\/strong>(pesticide)<\/li><li><strong>Leaky gut syndrome<\/strong><\/li><li><strong>Poor microbiome diversity<\/strong><\/li><li><strong>Mitochondrial disease<\/strong><\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1000\" height=\"667\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-3.jpg\" alt=\"\" class=\"wp-image-1447\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-3.jpg 1000w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-3-300x200.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-3-768x512.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<h3>The 5 Stages of Parkinson\u2019s Disease<\/h3>\n\n\n\n<h4>Stage 1<\/h4>\n\n\n\n<p>Symptoms appear but are mild in nature. They usually don\u2019t interfere with daily activities. The most common symptoms to appear are postural changes, muscle tremors, and changes in facial expression.<\/p>\n\n\n\n<h4>Stage 2<\/h4>\n\n\n\n<p>Stage two involves an increase in the severity of symptoms discovered in stage one and the development of symptoms affecting movement. It may be more difficult to walk normally, maintain correct posture, and normal tasks begin to become difficult. Usually, people in stage two don\u2019t require outside assistance.<\/p>\n\n\n\n<h4>Stage 3<\/h4>\n\n\n\n<p>This stage is characterized by problems with maintaining balance and difficulties with day-to-day activities such as eating, using the toilet, or getting dressed. People in stage three may need assistance, while others remain independent.<\/p>\n\n\n\n<h4>Stage 4<\/h4>\n\n\n\n<p>By stage four, symptoms have become pronounced. Standing is possible, but walking requires the support of a walker or another person. Daily activities such as eating, bathing, and moving around require assistance. People at this stage are not able to live independently.<\/p>\n\n\n\n<h4>Stage 5<\/h4>\n\n\n\n<p>This is the last stage of Parkinson\u2019s disease progression. Patients are unable to stand or walk on their own and are usually confined to a bed or wheelchair. Hallucinations and delusions may appear during this stage. Full-time assistance is required for people in this stage of disease.<\/p>\n\n\n\n<h3>How is Parkinson\u2019s Disease Treated?<\/h3>\n\n\n\n<p>Most of the treatments for Parkinson\u2019s disease are aimed at managing symptoms in order to optimize a patient\u2019s quality of life. There are several medications and supplements that improve dopamine production in the brain, but these won\u2019t cure the condition \u2014 only reduce the severity of symptoms associated with low dopamine. The medications will also need to be readjusted over time, along with regular follow ups with a neurologist. <\/p>\n\n\n\n<p><strong>Treatment Options for Parkinson\u2019s Disease and Symptoms Includes:<\/strong><\/p>\n\n\n\n<ul><li><strong>Amantadine<\/strong><\/li><li><strong>Anticholinergic drugs<\/strong><\/li><li><strong>Antidepressants <\/strong>(SNRIs, SSRIs, TCAs)<\/li><li><strong>Antioxidant supplementation<\/strong><\/li><li><strong>Cardio-aerobic exercise<\/strong><\/li><li><strong>Coffee consumption<\/strong><\/li><li><strong>COMT inhibitors<\/strong><\/li><li><strong>Deep brain stimulation<\/strong><\/li><li><strong>Dopaminergic medications <\/strong>(MAO-B Inhibitors, amphetamines)<\/li><li><strong>Ensure adequate, restful sleep each night<\/strong><\/li><li><strong>High fiber diets<\/strong><\/li><li><strong>L-dopa supplementation<\/strong><\/li><li><strong>Meditation\/yoga\/Tai-chi<\/strong><\/li><li><strong>Occupational therapy<\/strong><\/li><li><strong>Probiotic supplementation<\/strong><\/li><li><strong>Speech therapy<\/strong><\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img width=\"1000\" height=\"667\" src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-5.jpg\" alt=\"\" class=\"wp-image-1449\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-5.jpg 1000w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-5-300x200.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-parkinsons-5-768x512.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<h2>Key Takeaways: Can CBD Help With Parkinson\u2019s Disease?<\/h2>\n\n\n\n<p>There\u2019s no cure for Parkinson\u2019s disease \u2014 most of the treatment options available, including CBD are used to slow the progression of the disease and manage symptoms to improve a patient&#8217;s quality of life.<\/p>\n\n\n\n<p>CBD is a potentially excellent option for both \u2014 it may alleviate many of the most common side-effects of the conditions (insomnia, depression, anxiety, muscle tremors) and perhaps may slow the progression of Parkinson\u2019s, although more clinical research is needed to demonstrate this.<\/p>\n\n\n\n<p>It\u2019s important to consult with your doctor before using CBD to ensure it won\u2019t have any <a href=\"http:\/\/dailycbd.com\/en\/drug-interactions\/\">negative interactions with the medications<\/a> you\u2019re taking. Patients with Parkinson\u2019s disease will need multifaceted treatment and regular follow ups with their neurologist to readjust medication as needed. <\/p>\n\n\n\n<p>Anecdotally, Most Parkinson\u2019s patients use a high dose of CBD for long periods of time.<\/p>\n\n\n\n<p>For maximum benefits, opt for a high-potency <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/full-spectrum-oil\/\">full-spectrum CBD oil<\/a> to take advantage of other cannabinoids such as CBG that have their own set of benefits to offer Parkinson\u2019s symptoms.<\/p>\n\n\n\n<p>We also recommend using only high-quality CBD and hemp oils. Low-quality products may be contaminated with heavy metals or pesticides that can actually make symptoms even worse.<\/p>\n\n\n\n<p>Always do your research before buying CBD to make sure the companies you&#8217;re buying from use high-quality hemp, free from contaminants.<\/p>\n\n\n\n<h4>Tips for Getting the Most Out of CBD Supplementation for Parkinson\u2019s Disease<\/h4>\n\n\n\n<ol><li><strong>Choose a full-spectrum extract <\/strong>\u2014 other cannabinoids in the cannabis plant offer separate benefits to this condition<\/li><li><strong>Always choose a high-quality, certified organic CBD supplement<\/strong> \u2014 poor quality products are often contaminated with heavy metals, pesticides, or mold that can be neurotoxic<\/li><li><strong>Be consistent with dosing <\/strong>\u2014 it can take several weeks of regular use notice the benefits of the supplement.<\/li><li><strong>Always consult with your doctor before taking CBD<\/strong> \u2014&nbsp;some medications may have a negative interaction with the supplement<\/li><\/ol>\n\n\n\n<h2>References Cited In This Article<\/h2>\n\n\n\n<ol><li>Delaville, C., De Deurwaerd\u00e8re, P., &amp; Benazzouz, A. (2011). Noradrenaline and Parkinson&#8217;s disease. Frontiers in systems neuroscience, 5, 31.<\/li><li>Lemke, M. R. (2002). Effect of reboxetine on depression in Parkinson&#8217;s disease patients. The Journal of clinical psychiatry, 63(4), 300-304.<\/li><li>Lemke, M. R., Fuchs, G., Gemende, I., Herting, B., Oehlwein, C., Reichmann, H., &#8230; &amp; Volkmann, J. (2004). Depression and Parkinson\u2019s disease. Journal of Neurology, 251(6), vi24-vi27.<\/li><li>Jankovic, J., &amp; Tolosa, E. (Eds.). (2007). Parkinson&#8217;s disease and movement disorders. Lippincott Williams &amp; Wilkins.<\/li><li>Ozelius, L. J., Senthil, G., Saunders-Pullman, R., Ohmann, E., Deligtisch, A., Tagliati, M., &#8230; &amp; Lipton, R. B. (2006). LRRK2 G2019S as a cause of Parkinson&#8217;s disease in Ashkenazi Jews. New England Journal of Medicine, 354(4), 424-425.<\/li><li>Hirsch, E. C., &amp; Hunot, S. (2009). Neuroinflammation in Parkinson&#8217;s disease: a target for neuroprotection?. The Lancet Neurology, 8(4), 382-397.<\/li><li>Baker, D., Jackson, S. J., &amp; Pryce, G. (2007). Cannabinoid control of neuroinflammation related to multiple sclerosis. British journal of pharmacology, 152(5), 649-654.<\/li><li>Kluger, B., Triolo, P., Jones, W., &amp; Jankovic, J. (2015). The therapeutic potential of cannabinoids for movement disorders. Movement disorders, 30(3), 313-327.<\/li><li>Malfitano, A. M., Proto, M. C., &amp; Bifulco, M. (2008). Cannabinoids in the management of spasticity associated with multiple sclerosis. Neuropsychiatric disease and treatment, 4(5), 847.<\/li><li>Dowie, M. J., Howard, M. L., Nicholson, L. F. B., Faull, R. L. M., Hannan, A. J., &amp; Glass, M. (2010). Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington&#8217;s disease transgenic mice. Neuroscience, 170(1), 324-336.<\/li><li>Crippa, J. A., Guimar\u00e3es, F. S., Campos, A. C., &amp; Zuardi, A. W. (2018). Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Frontiers in Immunology, 9. https:\/\/doi.org\/10.3389\/FIMMU.2018.02009<\/li><li>Russo, E. B., Guy, G. W., &amp; Robson, P. J. (2007, August 1). Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of sativex\u03c1, a cannabis-based medicine. Chemistry and Biodiversity. Wiley-Blackwell. https:\/\/doi.org\/10.1002\/cbdv.200790150<\/li><li>Sleep disorders in Parkinson&#8217;s disease: Diagnosis and management. Ann Indian Acad Neurol. 2011;14(Suppl 1):S18-20.<\/li><li>Evans, F. J. (1991). Cannabinoids: the separation of central from peripheral effects on a structural basis. Planta medica, 57(S 1), S60-S67.<\/li><li>Morales, P., Isawi, I., &amp; Reggio, P. H. (2018). Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12. Drug metabolism reviews, 50(1), 74-93.<\/li><li>Laun, A. S., &amp; Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17-21.<\/li><li> Benatti, C.,&nbsp;Blom, J.M.,&nbsp;Rigillo, G.,&nbsp;Alboni, S.,&nbsp;Zizzi, F.,&nbsp;Torta, R.,&nbsp;Brunello, N., &amp;&nbsp;Tascedda F. (2016) Disease-Induced&nbsp;Neuroinflammation&nbsp;and&nbsp;Depression. CNS &amp; Neurological Disorders Drug Targets,  15(4), 414-33. <\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Parkinson\u2019s disease is an incurable neurodegenerative disorder. <\/p>\n<p>Evidence suggests CBD may be able to provide relief from some of the most irritating symptoms. <\/p>\n<p>Here&#8217;s how it works.<\/p>\n","protected":false},"author":10,"featured_media":691,"parent":0,"menu_order":66,"template":"","crb_condition_category":[2833,48,66],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CBD Oil For Parkinson&#039;s Disease: Best Products, Safety, &amp; Dosage<\/title>\n<meta name=\"description\" content=\"Studies show CBD relieves muscle tremors, insomnia, and nerve damage involved with Parkinson&#039;s disease. 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