{"id":251,"date":"2019-11-22T08:28:00","date_gmt":"2019-11-22T08:28:00","guid":{"rendered":"http:\/\/dailycbd.com\/english\/?post_type=crb_condition&#038;p=251"},"modified":"2021-10-20T15:55:21","modified_gmt":"2021-10-20T15:55:21","slug":"neurodegeneration","status":"publish","type":"crb_condition","link":"https:\/\/dailycbd.com\/en\/best-cbd\/neurodegeneration\/","title":{"rendered":"Neurodegeneration"},"content":{"rendered":"\n<h2>The Benefits of CBD Oil For Brain Health<\/h2>\n\n\n\n<p>Neurodegenerative disorders are characterized by a gradual loss of neurons in particular regions of the nervous system. This cell loss causes a decline in cognitive ability and accounts for most of the symptoms experienced with this condition.<\/p>\n\n\n\n<p><strong>How CBD Protects the Brain &amp; Neurons<\/strong><\/p>\n\n\n\n<ul><li>Reducing brain inflammation<\/li><li>Preventing T-cell migration across the blood-brain barrier (prevents autoimmunity)<\/li><li>Antioxidant support (protects the DNA from damage)<\/li><li>Alleviates anxiety<\/li><li>May relieve depression<\/li><li>May improve muscle control &amp; alleviate muscle tremors<\/li><li>My promote recovery of damaged neurons<\/li><\/ul>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-neurodegeneration-1.jpg\" alt=\"\" class=\"wp-image-1318\" width=\"838\" height=\"416\" \/><\/figure><\/div>\n\n\n\n<h2>CBD For Degenerative Brain Disorders<\/h2>\n\n\n\n<p><strong>Cannabis may support neurodegenerative disorders including: <\/strong><\/p>\n\n\n\n<ul><li><strong>Alzheimer\u2019s disease<\/strong><\/li><li><strong>Parkinson\u2019s disease<\/strong><\/li><li><strong>Multiple sclerosis (MS)<\/strong><\/li><li><strong>Huntington\u2019s Disease<\/strong><\/li><li><strong>Prion disease<\/strong> (minor improvement)<\/li><li><strong>Lou Gehrig&#8217;s Disease (ALS)<\/strong><\/li><li><strong>Spinocerebellar Ataxia (SCA)<\/strong><\/li><li><strong>Spinal Muscular Atrophy (SMA)<\/strong><\/li><\/ul>\n\n\n\n<h3>1. Alzheimer\u2019s Disease<\/h3>\n\n\n\n<p><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/alzheimers-disease\/\">Alzheimer\u2019s disease<\/a> is the most common form of neurodegeneration. It involves the buildup of toxic metabolites (TAU proteins or beta-amyloid plaque) around the neurons. Eventually, this results in neuron death and gradual cognitive debility. Alzheimer\u2019s disease, like most other neurodegenerative disorders, is associated with excessive neuroinflammation [<a href=\"https:\/\/www.nature.com\/articles\/ncpneuro0355\">11<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0166223606001652\">12<\/a>].<\/p>\n\n\n\n<p>CBD offers benefits to this condition primarily through its anti-inflammatory effects.<\/p>\n\n\n\n<h3>2. Parkinson\u2019s Disease<\/h3>\n\n\n\n<p><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/parkinsons-disease\/\">Parkinson\u2019s disease<\/a> is a neurodegenerative disorder affecting the basal ganglia where dopamine is manufactured. The result is a gradual loss of dopamine in the brain, causing muscle tremors, mood changes, and a gradual loss of cognitive function.<\/p>\n\n\n\n<p>Like Alzheimer\u2019s disease, Parkinson&#8217;s is considered to rely on excessive inflammatory processes in the brain [<a href=\"https:\/\/www.nature.com\/articles\/ncpneuro0355\">11<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0166223606001652\">12<\/a>].<\/p>\n\n\n\n<p>CBD, therefore, offers relief from this condition through its anti-inflammatory and neuroprotective actions.<\/p>\n\n\n\n<h3>3. Multiple Sclerosis (MS)<\/h3>\n\n\n\n<p><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/multiple-sclerosis\/\">Multiple sclerosis<\/a> is an autoimmune-driven neurodegenerative disorder. Widespread neuroinflammation causes immune cells to attack the myelin sheath on the nerve cells, causing a gradual loss of neuron function.<\/p>\n\n\n\n<p>CBD is very beneficial to this condition through its immunomodulatory and anti-inflammatory effects \u2014 both of which are primary factors involved with the progression of MS [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0969996113001939\">15<\/a>]. <\/p>\n\n\n\n<p>Additionally, CBD may provide direct benefits to some of the most common side-effects of MS, including muscle spasticity [<a href=\"https:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/1352458511419700\">16<\/a>] and loss of bladder control [<a href=\"https:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/1352458510367462\">17<\/a>].<\/p>\n\n\n\n<p><strong>Related: <a href=\"http:\/\/dailycbd.com\/en\/ratios\/multiple-sclerosis\/\">Best CBD:THC Ratio for Multiple Sclerosis<\/a>.<\/strong><\/p>\n\n\n\n<h3>4. Huntington\u2019s Disease<\/h3>\n\n\n\n<p><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/huntingtons-disease\/\">Huntington&#8217;s disease<\/a> is a neurodegenerative disorder with similar characteristics to Alzheimer\u2019s disease. It\u2019s a genetic disorder involving dysfunction in the gene encoding for a protein called huntingtin. People with Huntington&#8217;s disease manufacture huntingtin proteins that are too long. They fracture into smaller pieces and become tangled around the neurons \u2014 leading to their gradual death. As Huntington builds up, it causes widespread inflammation throughout the brain and loss of cognitive function over time.<\/p>\n\n\n\n<p>There is no cure for Huntington&#8217;s disease, but CBD has been shown to offer significant benefits \u2014 slowing progression and alleviating many of the most common symptoms [<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jnr.22682\">14<\/a>].<\/p>\n\n\n\n<h3>5. Creutzfeldt-Jakob Disease (CJD) and Other Prion Diseases<\/h3>\n\n\n\n<p><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/prion-mad-cow\/\">Prion diseases<\/a> such as CJD aren\u2019t common but bring devastating side effects as the disease progresses. It involves a misfolded, protease-resistant protein (PrPres) entering the brain and replicating. Being resistant to protease means that the brain cells cannot break down and remove this protein from the brain. Therefore, as these proteins replicate and build up in the brain, they begin to interfere with healthy brain function. Currently, there\u2019s no cure for prion diseases.<\/p>\n\n\n\n<p>Although inflammation is a primary factor involved with prion disease progression, CBD has only been shown to have minor benefits on the condition by resisting the buildup of PrPres [<a href=\"http:\/\/www.jneurosci.org\/content\/27\/36\/9537.short\">13<\/a>].<\/p>\n\n\n\n<h3>6. Amyotrophic Lateral Sclerosis (ALS)<\/h3>\n\n\n\n<p><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/als\/\">Lou Gehrig&#8217;s Disease (ALS)<\/a> is a neurodegenerative disease causing gradual \u2014 and ultimately fatal \u2014 disruption in signals controlling voluntary muscles throughout the body.<\/p>\n\n\n\n<p>There is no cure for ALS, but CBD has been shown to offer significant benefits.<\/p>\n\n\n\n<h3>7. Spinocerebellar Ataxia (SCA)<\/h3>\n\n\n\n<p>SCA is a progressive, inherited neurodegenerative disease affecting the cerebellum \u2014 the part of the brain associated with coordination and muscle movement. There is no cure for the disease, and it\u2019s often fatal.<\/p>\n\n\n\n<p>Treatment is focused on alleviating symptoms such as muscle tremors, depression, and insomnia \u2014&nbsp;all of which CBD is well-known to help.<\/p>\n\n\n\n<h3>8. Spinal Muscular Atrophy (SMA)<\/h3>\n\n\n\n<p>SMA is a rare neurodegenerative disorder affecting the motor neurons controlling the muscles. Eventually, the disease causes loss of muscle function and muscle wasting. Like many other neurodegenerative disorders, the condition is caused by a dysfunction in producing a particular protein in the brain. Over time, these dysfunctional proteins build-up, resulting in the death of the neurons. There is no cure for this condition.<\/p>\n\n\n\n<p>It\u2019s unclear whether CBD is beneficial to those with SMA. The majority of side-effects of this condition involve muscle weakness \u2014 something CBD isn\u2019t thought to improve.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-neurodegeneration-3.jpg\" alt=\"\" class=\"wp-image-1320\" width=\"728\" height=\"436\" srcset=\"https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-neurodegeneration-3.jpg 1000w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-neurodegeneration-3-300x180.jpg 300w, https:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-neurodegeneration-3-768x461.jpg 768w\" sizes=\"(max-width: 728px) 100vw, 728px\" \/><\/figure><\/div>\n\n\n\n<h2>How to Use CBD Oil For Brain Health<\/h2>\n\n\n\n<p><strong>Tips for Getting the Most Out of Using CBD for Neurodegenerative Disorders:<\/strong><\/p>\n\n\n\n<ol><li>Use a full-spectrum extract (<a href=\"http:\/\/dailycbd.com\/en\/thc-oil\/\">THC<\/a> also offers benefits for these conditions)<\/li><li>Incorporate improvements of diet and lifestyle choices at the same time as CBD supplementation<\/li><li>If there is an environmental cause (such as heavy metal exposure), make sure this is removed immediately<\/li><li>Be consistent with dosing \u2014 it can take up to three months before any changes are experienced when it comes to neurodegenerative disorders<\/li><\/ol>\n\n\n\n<h3>What&#8217;s Are The Best CBD Products For Brain Health? <\/h3>\n\n\n\n<p>Neurodegenerative disorders are a combination of many different neurological and systemic issues working together to produce a gradual loss of neurons.<\/p>\n\n\n\n<p><strong>Therefore, treating these conditions isn\u2019t as straightforward as just addressing one of these issues at a time \u2014 it relies on addressing several of them at the same time. <\/strong><\/p>\n\n\n\n<p><a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/\">CBD oils<\/a> and other cannabis products should, therefore, be combined with other treatments and lifestyle and dietary changes for best results.<\/p>\n\n\n\n<p><strong>So, when searching for the best oils for neurodegenerative disorders, there are two things to consider:<\/strong><\/p>\n\n\n\n<ol><li>Has the CBD product been proven to be free from contaminants such as heavy metals or pesticides?<\/li><li>Does the potency of the CBD product match the recommended dose? In the case of neurodegenerative disorders, this usually means using a high-potency extract.<\/li><\/ol>\n\n\n\n<p>It\u2019s also useful to opt for a full-spectrum CBD extract rather than an isolate if you want to leverage the neuroprotective benefits of some of the other cannabinoids. However, if this isn\u2019t possible, or you\u2019ve decided you like a company selling CBD isolates, that\u2019s okay. It will still work but just isn\u2019t the <em>best <\/em>CBD oil for the job.<\/p>\n\n\n\n<h3>What Dose Of CBD Should I Use For Neurodegenerative Disease? <\/h3>\n\n\n\n<p>Most of the research involving CBD and other cannabinoids for neurodegenerative disorders involve very high doses \u2014 usually in the realm of around 500 mg per day.<\/p>\n\n\n\n<p>Although it may not be totally necessary to use a dose this high, it does suggest that the <em>heavy<\/em> end of the dosage range is the most beneficial.<\/p>\n\n\n\n<p>Use our <a href=\"http:\/\/dailycbd.com\/en\/cbd-dosage\/\">CBD oil dosage calculator<\/a> below to find the best dose for you based on your weight. <\/p>\n\n\n\n<p>Remember to start low and build up over time. Everyone reacts differently to CBD, so it\u2019s therefore important that you take a conservative approach to find the right dose to avoid any negative side effects.<\/p>\n\n\n\n<p><strong>Recommended strength for neurodegenerative disorders: medium to high strength<\/strong><\/p>\n\n\n\n<h4 class=\"has-text-align-center\">CBD Dosage Calculator<\/h4>\n\n\n\n    <div>\n        <div class=\"calc-wr\">\n            <form method=\"post\">\n                <div class=\"calc\" id=\"calculator-583\">\n                    <div class=\"calc--r calc--r-weight\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-weight\"><\/span>Your Weight<\/div>\n                        <div class=\"input-wr\">\n                            <span id=\"weight-sl--vl\"><\/span>\n                            <input type=\"number\" name=\"weight\" value=\"\" min=\"0\" tabindex=\"0\"\/>\n                        <\/div>\n                        <div class=\"calc--u-tabs\">\n                            <input type=\"radio\" id=\"unit-lb\" name=\"unit\" value=\"lb\" class=\"u-t--i\" checked><label for=\"unit-lb\" class=\"u-t--l first\" tabindex=\"1\">lb<\/label>\n                            <input type=\"radio\" id=\"unit-kg\" name=\"unit\" value=\"kg\" class=\"u-t--i\"><label for=\"unit-kg\" class=\"u-t--l\" tabindex=\"2\">kg<\/label>\n                        <\/div>\n                        <div\n                                id=\"weight-slider\"\n                                data-range=\"max\"\n                                data-min=\"0\"\n                                data-max=\"440\"\n                                data-step=\"1\"\n                                data-value=\"\"\n                                data-type=\"\"\n                                class=\"calc--sl\">\n                        <\/div>\n                    <\/div>\n                    <div class=\"calc--r calc--r-strength\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-strength\"><\/span>Desired Strength<\/div>\n                        <div class=\"calc--radio-str\">\n                            <input type=\"radio\" id=\"strength-mild\" name=\"strength\" value=\"mild\" class=\"radio-str--i\"><label for=\"strength-mild\" class=\"radio-str--l first\" tabindex=\"3\">Mild\n                                <span class=\"lb-tooltip\">Mild Dose (General Health, Nausea)<\/span><\/label>\n                            <input type=\"radio\" id=\"strength-moderate\" name=\"strength\" value=\"moderate\" class=\"radio-str--i\"><label for=\"strength-moderate\" class=\"radio-str--l second\" tabindex=\"4\">Moderate\n                                <span class=\"lb-tooltip\">Moderate Dose (Nausea, Pain, Inflammation, Mild Insomnia, Mild Anxiety, Headaches)<\/span><\/label>\n                            <input type=\"radio\" id=\"strength-heavy\" name=\"strength\" value=\"heavy\" class=\"radio-str--i\"><label for=\"strength-heavy\" class=\"radio-str--l\" tabindex=\"5\">Heavy\n                                <span class=\"lb-tooltip\">Heavy Dose (Chronic pain, Inflammation, Insomnia, Anxiety, Migraines, Epilepsy)<\/span><\/label>\n                        <\/div>\n                    <\/div>\n                    <div class=\"calc--r calc--r-totalcbd\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-totalcbd\"><\/span>Total CBD (optional)<span class=\"ask-tooltip\"><\/span><span class=\"lb-tooltip\">How much CBD is in the bottle (found on the label)?<\/span><\/div>\n                        <div class=\"input-wr\">\n                            <input type=\"number\" name=\"totalcbd\" value=\"\" class=\"input-wr--i\" placeholder=\"500\" tabindex=\"6\">\n                            <span class=\"input-wr--u\">mg<\/span>\n                        <\/div>\n                    <\/div>\n                    <div class=\"calc--r calc--r-volume\">\n                        <div class=\"calc--lb\"><span class=\"lb-icon lb-icon-volume\"><\/span>Volume (optional)<span class=\"ask-tooltip\"><\/span><span class=\"lb-tooltip\">How big is your bottle of CBD?<\/span><\/div>\n                        <div class=\"select-wr\">\n                            <select name=\"volume\" id=\"volume-select\" tabindex=\"7s\">\n                                <option selected value>&#8212;<\/option>\n                                <option value=\"15\">15 mL (0.5 oz)<\/option>\n                                <option value=\"30\">30 mL (1 oz)<\/option>\n                                <option value=\"50\">50 mL (1.7 oz)<\/option>\n                                <option value=\"60\">60 mL (2 oz)<\/option>\n                                <option value=\"120\">120 mL (4 oz)<\/option>\n                            <\/select>\n                        <\/div>\n                    <\/div>\n<!--                    <div><input type=\"hidden\" name=\"br\" data-id=\"--><!--\"><\/div>-->\n   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class=\"cta-tooltip-text\">Include this code unmodified to your website to display the calculator.\n                                The widget will appear exactly where you insert the code.\n                                Copy the code, and paste it into your site\\&#8217;s HTML code.<\/p>\n                        <\/div>\n                    <\/form>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n    \n        <script type=\"text\/javascript\">\nwindow.addEventListener('DOMContentLoaded', function() {\n            jQuery(document).ready(function($) {\n                $(this).Calculator(583, false);\n            });\n            });\n\n        <\/script>\n\n    \n\n\n\n<h3>How Long Will It Take To Notice Improvement? <\/h3>\n\n\n\n<p>Neurodegenerative disorders are long-term medical conditions \u2014 and most of them have no\u00a0cure. CBD can be used to slow the progression of the disease and alleviate common side effects but isn\u2019t going to cure the condition.<\/p>\n\n\n\n<p>Therefore, it\u2019s helpful to track the progress of the disease over time to identify whether the CBD is working or if the dose needs to be increased.<\/p>\n\n\n\n<p>You can do this by taking detailed notes about your symptoms. Then, you can go back and see if there have been any improvements over time. Additionally, in the case of progressive neurodegenerative disorders, you can track the rate of progression of the disease.<\/p>\n\n\n\n<h2>What Is Neurodegenerative Disease? <\/h2>\n\n\n\n<p>Neurodegeneration is an umbrella term for a series of unrelated medical conditions that result in a loss of neuron function.<\/p>\n\n\n\n<p>The primary cause for this condition is dementia, including Alzheimer\u2019s disease \u2014 accounting for up to 70% of cases around the world, according to <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"http:\/\/www.neurodegenerationresearch.eu\/about\/why\/\" target=\"_blank\">JPND Research. <\/a><\/p>\n\n\n\n<p>These disorders are generally progressive, worsening in severity and rate of degeneration over time. This can take any time from a few months to a few decades. However, the process of neurodegeneration usually begins long before symptoms start to appear.<\/p>\n\n\n\n<p>Evidence in recent years has pointed the finger at inflammation in the brain as one of the primary drivers of neurodegeneration [<a href=\"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/full\/10.1196\/annals.1403.002\">8<\/a>]. The problem with this is that it\u2019s also necessary for resisting neurological damage \u2014 prompting researchers to regard neuroinflammation as the \u201cdouble-edged sword\u201d of neurodegeneration.<\/p>\n\n\n\n<p>When something causes damage to the neurons in the brain \u2014 for which there are too many potential causes to count \u2014 local immune cells start the inflammatory process.<\/p>\n\n\n\n<p>In the early stages, this is beneficial \u2014\u00a0even necessary \u2014\u00a0for eliminating toxic materials. This is because inflammation speeds the recovery of the neurons by boosting blood flow to the area and bringing in defensive immune cells to remove any infectious materials.<\/p>\n\n\n\n<p>The problem is that, in many cases, this inflammation goes out of control, causing a cascade of devastating, long-term inflammation in the brain. Excessive inflammation causes the microglia to release toxic substances into the brain, ultimately leading to the death of the neurons. These microglia are tasked with keeping the neurons safe [<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1177\/011542650802300135\">9<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0165614708001442\">10<\/a>].<\/p>\n\n\n\n<p>The whole process goes from a typical inflammatory response to a devastating, self-perpetuating process of degeneration and loss of neurons.<\/p>\n\n\n\n<h3>What Causes Degenerative Brain Disease?<\/h3>\n\n\n\n<ol><li><strong>Environmental toxic exposure<\/strong> <strong>(such as heavy metal exposure)<\/strong><\/li><li><strong>Nutritional deficiencies<\/strong><\/li><li><strong>Stroke<\/strong><\/li><li><strong>Cancer<\/strong><\/li><li><strong>Oxidative damage<\/strong><\/li><li><strong>Genetic factors<\/strong><\/li><\/ol>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img src=\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cbdworld-neurodegeneration-2.jpg\" alt=\"\" class=\"wp-image-1319\" width=\"792\" height=\"488\" \/><\/figure><\/div>\n\n\n\n<h2>When to Avoid Using CBD or Cannabis-Related Products<\/h2>\n\n\n\n<p>Even though CBD is very safe, there are some instances when you must first consult with an experienced medical professional before taking it:<\/p>\n\n\n\n<ul><li>If you have psychosis<\/li><li>If you have <a href=\"http:\/\/dailycbd.com\/en\/best-cbd\/bipolar-disorder\/\">bipolar disorder<\/a> (caution advised)<\/li><li>Whenever taking antipsychotics or certain antidepressants<\/li><\/ul>\n\n\n\n<h2>Key Takeaways: How Does CBD Support Brain Health? <\/h2>\n\n\n\n<p>Researchers are still disputing exactly <em>how<\/em> CBD and other cannabinoids are effective for slowing the progression of neurodegenerative disorders. <\/p>\n\n\n\n<p>The interaction between CBD and the nervous system is complex \u2014&nbsp;involving multiple separate processes going on at the same time.<\/p>\n\n\n\n<p>However, the general idea is that CBD supports the homeostasis of the nervous system. This means it supports the balance of various factors involved with neurological function, including inflammation, pain transmission, nerve excitability, and immune function.<\/p>\n\n\n\n<hr class=\"wp-block-separator\" \/>\n\n\n\n<h2>References<\/h2>\n\n\n\n<ol><li>Przedborski, S., Vila, M., &amp; Jackson-Lewis, V. (2003). Series Introduction: Neurodegeneration: What is it and where are we?. The Journal of clinical investigation, 111(1), 3-10.<\/li><li>Wade, D. T., Collin, C., Stott, C., &amp; Duncombe, P. (2010). Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Multiple Sclerosis Journal, 16(6), 707-714.<\/li><li>Mart\u00edn-Moreno, A. M., Reigada, D., Ram\u00edrez, B. G., Mechoulam, R., Innamorato, N., Cuadrado, A., &amp; de Ceballos, M. L. (2011). Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers\u2032 disease. Molecular pharmacology, mol-111.<\/li><li>Barnes, M. P. (2006). Sativex\u00ae: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain. Expert opinion on pharmacotherapy, 7(5), 607-615.<\/li><li>Kwiatkoski, M., Guimaraes, F. S., &amp; Del-Bel, E. (2012). Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury. Neurotoxicity research, 21(3), 271-280.<\/li><li>Dirikoc, S., Priola, S. A., Marella, M., Zs\u00fcrger, N., &amp; Chabry, J. (2007). Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity. Journal of Neuroscience, 27(36), 9537-9544.<\/li><li>Chagas, M. H. N., Zuardi, A. W., Tumas, V., Pena-Pereira, M. A., Sobreira, E. T., Bergamaschi, M. M., &#8230; &amp; Crippa, J. A. S. (2014). Effects of cannabidiol in the treatment of patients with Parkinson\u2019s disease: an exploratory double-blind trial. Journal of Psychopharmacology, 28(11), 1088-1098.<\/li><li>Skaper, S. D. (2007). The brain as a target for inflammatory processes and neuroprotective strategies. Annals of the New York Academy of Sciences, 1122(1), 23-34.<\/li><li>DeLegge, M. H., &amp; Smoke, A. (2008). Neurodegeneration and inflammation. Nutrition in clinical practice, 23(1), 35-41.<\/li><li>Di Filippo, M., Sarchielli, P., Picconi, B., &amp; Calabresi, P. (2008). Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders. Trends in pharmacological sciences, 29(8), 402-412.<\/li><li>Maragakis, N. J., &amp; Rothstein, J. D. (2006). Mechanisms of disease: astrocytes in neurodegenerative disease. Nature Reviews Neurology, 2(12), 679.<\/li><li>Zipp, F., &amp; Aktas, O. (2006). The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends in neurosciences, 29(9), 518-527.<\/li><li>Dirikoc, S., Priola, S. A., Marella, M., Zs\u00fcrger, N., &amp; Chabry, J. (2007). Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity. Journal of Neuroscience, 27(36), 9537-9544.<\/li><li>Sagredo, O., Pazos, M. R., Satta, V., Ramos, J. A., Pertwee, R. G., &amp; Fern\u00e1ndez\u2010Ruiz, J. (2011). Neuroprotective effects of phytocannabinoid\u2010based medicines in experimental models of Huntington&#8217;s disease. Journal of neuroscience research, 89(9), 1509-1518.<\/li><li>Mecha, M., Feli\u00fa, A., I\u00f1igo, P. M., Mestre, L., Carrillo-Salinas, F. J., &amp; Guaza, C. (2013). Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors. Neurobiology of disease, 59, 141-150.<\/li><li>Notcutt, W., Langford, R., Davies, P., Ratcliffe, S., &amp; Potts, R. (2012). A placebo-controlled, parallel-group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex\u00ae(nabiximols). Multiple Sclerosis Journal, 18(2), 219-228.<\/li><li>Wade, D. T., Collin, C., Stott, C., &amp; Duncombe, P. (2010). Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Multiple Sclerosis Journal, 16(6), 707-714.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Neurodegeneration is an umbrella term used to describe any progressive loss of neuron function. <\/p>\n<p>CBD helps protect the brain from natural degeneration in four key ways \u2014\u00a0antioxidant, anti-inflammatory, immune-modulation, and sleep-support.<\/p>\n","protected":false},"author":10,"featured_media":687,"parent":0,"menu_order":56,"template":"","crb_condition_category":[2833,48],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CBD For Neurodegeneration: How CBD Protects The Brain As We Age<\/title>\n<meta name=\"description\" content=\"CBD helps protect the brain from degeneration &amp; damage. 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