- CBD regulates key immune cells tasked with detecting & eliminating cancer cells from the body<\/strong><\/li>
- CBD may alleviate cancer-related pain<\/strong><\/li>
- CBD supports sleep duration and quality<\/strong><\/li>
- Cannabinoids related to CBD may boost hunger levels<\/strong><\/li>
- CBD may slow tumor growth<\/strong><\/li>
- CBD alleviates nausea & vomiting<\/a> associated with chemotherapy<\/strong><\/li>
- CBD may support anxiety & depression associated with a cancer diagnosis<\/strong><\/li><\/ol>\n\n\n\n
1. CBD Regulates Key Immune Cells\nTasked With Detecting & Eliminating Cancer Cells From the Body<\/h3>\n\n\n\n
Most people have had cancer cells in their bodies at one point or another. <\/p>\n\n\n\n
Normally,\nthe immune system is able to identify the cancerous cells early and dispose of\nthem. Specialized immune cells are tasked with performing this important job of\ndetecting, and eliminating abnormal cells such as cancer. The most important of\nthese immune cells are the T-Cells (T-lymphocytes) and NK cells (natural killer\ncells) [15<\/a>, 16<\/a>]. <\/p>\n\n\n\n
Sometimes the immune system is tricked by cancer to believe it\u2019s not a threat \u2014 allowing it to grow out of control in the body [21<\/a>]. <\/p>\n\n\n\n
Scientists\nbelieve CBD may provide anti-cancer benefits through its interaction with the\nCB2 endocannabinoid receptors \u2014 which have been shown to be present on\nT-lymphocytes, B-lymphocytes, and Natural Killer (NK) cells [14<\/a>] but are most abundant on B-cells and NK\ncells [22<\/a>].<\/p>\n\n\n\n
This\ninteraction is highly complex and researchers are still seeking to understand\nhow CBD and other cannabinoids affect the immune system\u2019s ability to detect and\neliminate cancerous cells throughout the body. However, the current\nunderstanding, as highlighted by a Polish review paper published in 2017, is\nthat CBD supports a shift in immune activation from being TH2 dominant\n(commonly found in cancer patients) to TH1 dominant (believed to resist cancer\ngrowth) [5<\/a>, 24]<\/a>.<\/p>\n\n\n\n
If\nyou\u2019re not sure what TH1 and TH2 immune responses are, don\u2019t worry \u2014 it\u2019s\nextremely complicated, and medical researchers who have dedicated their entire\nlives to the study of immune function still have a lot of unanswered questions\nabout this particular interaction. <\/p>\n\n\n\n
In basic terms, the immune\nsystem has two main sides \u2014 TH1, and TH2 \u2014 each one optimized for a different\njob:<\/strong><\/p>\n\n\n\n
- TH1 is better for attacking and removing invading pathogens but is also a perpetuating factor for autoimmune disease. <\/li>
- TH2 is more involved in maintaining inflammatory reactions and allergies. <\/li><\/ol>\n\n\n\n
Unfortunately,\nthis system can become disoriented during cancer, and TH1\/TH2 can either make\ncancer better or worse [32<\/a>]. <\/p>\n\n\n\n
Sometimes this system needs a\npush in the right direction to make sure the right part of the tool is being\nused for the job.<\/strong><\/p>\n\n\n\n
2. CBD May Alleviate Cancer-Related Pain<\/h3>\n\n\n\n
One\nof the main side effects of cancer is pain \u2014 which can be debilitating.<\/p>\n\n\n\n
Pain\nis often caused by the tumor pressing on nerves, bones, and organs in the body.\nChemotherapy medications also cause pain as a side effect, with tingling and\nnumbness often experienced in the fingers and toes [25<\/a>].<\/p>\n\n\n\n
This\nmakes pain management one of the main goals for doctors treating those with\ncancer. <\/p>\n\n\n\n
CBD is an excellent option for managing the pain experienced by cancer patients because it works through more than one mechanism to achieve this effect. <\/strong><\/p>\n\n\n\n
CBD\nis thought to work through activation of the vanilloid pain receptors [17<\/a>] \u2014 which are known to play a pivotal role\nin blocking the transmission of pain to the spinal cord and brain [18<\/a>].<\/p>\n\n\n\n
In a recent study, an extract containing both CBD and THC was shown to relieve pain<\/a> in patients with advanced cancer where opioids were ineffective [7<\/a>].<\/p>\n\n\n\n
3. CBD Supports Sleep<\/h3>\n\n\n\n
Chronic pain associated with cancer, along\nwith other side effects like anxiety and depression can make it difficult for\npatients to fall asleep and stay asleep. <\/p>\n\n\n\n
CBD may\nhelp by reducing symptoms like pain and anxiety that can interfere with sleep. <\/strong><\/p>\n\n\n\n
A recent review article highlighting the years of phase I, II, and III clinical trials conducted with the cannabinoid-based pharmaceutical preparation, Sativex, showed significant improvements in sleep quality<\/a> and duration among cancer patients as well as other chronic and life-threatening health conditions [8<\/a>]. <\/p>\n\n\n\n
This review included information gathered from 2000 different patients and roughly 1000 patient years of exposure to the medication. <\/p>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cancer-2.jpg\")
<\/figure><\/div>\n\n\n\n4. Related Cannabinoids May Boost\nHunger Levels<\/h3>\n\n\n\n
One of\nthe main side effects of cancer treatment is a reduced appetite.<\/strong><\/p>\n\n\n\n
A healthy appetite is vitally important to\nsupply the body with the nutrients it needs to promote recovery. <\/p>\n\n\n\n
If we\u2019re not eating enough, it makes it even\nmore difficult for the body to fight cancer, so ensuring we eat enough food is\nof the utmost importance. <\/p>\n\n\n\n
CBD isn\u2019t known for its ability to increase appetite<\/a>.<\/strong> This effect is mainly attributed to the THC content of marijuana instead. A phase II clinical trial published in 1994 showed that 13 out of 19 cancer patients experiencing severe weight loss and appetite suppression had significantly increased appetite and weight gain after taking THC [20<\/a>]. <\/p>\n\n\n\n
Although not legal in many states, THC has\nactually been shown to offer significant improvements in appetite [13<\/a>]. So if you can get access to CBD oil with\nTHC, this is likely to offer the most benefit on this effect. <\/p>\n\n\n\n
5. CBD May Slow Tumour Growth <\/h3>\n\n\n\n
The main goal of cancer treatment is to stop\ntumors from growing and to give the body the best chance of fighting back. <\/p>\n\n\n\n
CBD oil has been shown to inhibit tumor cell\ngrowth and helps to stop it from spreading to other areas of the body. <\/p>\n\n\n\n
In some patients, the use of CBD has led to\ndecreased tumor cell growth rate and invasion [5<\/a>]. Most of the research in this domain\ninvolves animal studies and are in need of long-term clinical trials involving\nhumans to be confirmed. <\/p>\n\n\n\n
However, there has been plenty of research\nshowing a reduction in tumors through animal and in vitro research \u2014 such as\nthis on pancreatic cancer [23<\/a>], brain cancer [26<\/a>], and colon cancer [27], to name a few. <\/p>\n\n\n\n
There are a few suggested theories as to how CBD is able to reduce tumor size in cancerous tumors \u2014 such as through anti-inflammatory, antioxidant, and immunomodulatory effects, as well as induced-apoptosis (programmed cell death) \u2014 however, this depends highly on the form of cancer being treated along with a host of other factors. <\/p>\n\n\n\n
6. CBD Alleviates Nausea &\nVomiting<\/h3>\n\n\n\n
Nausea and vomiting are both common side effects of chemotherapy.<\/strong> Treating these symptoms will offer a significant improvement in cancer patients\u2019 overall quality of life. <\/p>\n\n\n\n
Cannabis has been used for centuries to relieve both nausea and vomiting. There is both anecdotal and research-based evidence supporting the use of CBD for therapeutic improvement in chemotherapy-induced nausea and vomiting [9<\/a>]. <\/p>\n\n\n\n
The\nlargest of these studies was a Cochrane review that analyzed the results of 23\nclinical trials involving cannabinoids \u2014 which concluded that cannabinoids\nwere highly effective and providing similar results to conventional treatments\nfor alleviating chemotherapy-induced nausea and vomiting [28<\/a>].<\/p>\n\n\n\n
It\u2019s\nworth noting that some studies found the opposite effect [7]. So it’s worth\ngiving CBD a try before relying on it to alleviate nausea and vomiting. This\ncan be very different from one person to the next. <\/p>\n\n\n\n
7. CBD May Support Anxiety & Depression Associated With a Cancer\nDiagnosis<\/h3>\n\n\n\n
A\ncancer diagnosis can be extremely stressful, and many people suffer from\ndepression and anxiety during and after treatment <\/strong>(anywhere\nfrom 0%\u201358% depending on the study and stage\/type of cancer) [29<\/a>]. <\/p>\n\n\n\n
Reducing anxiety and depression are considered\none of the most important treatment steps for supporting cancer recovery and\nimproving the quality of life of those affected.<\/p>\n\n\n\n
CBD has well-known benefits for reducing symptoms of depression and anxiety \u2014 which has been studied thoroughly through animal testing [30<\/a>]. Several clinical trials<\/a> are currently underway to investigate the specific effect of using CBD on humans suffering from various forms of depression. <\/p>\n\n\n\n
More research is needed to prove these effects\nin humans. <\/p>\n\n\n\n
When this is combined with lifestyle changes, supportive friends and family, and a lot of personal contemplation, it can be an extremely powerful tool in alleviating depression<\/a>, anxiety, and overall health and wellbeing. <\/p>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cancer-ribbon-CBD-condition.jpg\")
<\/figure><\/div>\n\n\n\nWhat is Cancer? <\/h2>\n\n\n\n
The World Health Organization (WHO)<\/a> states that cancer is the second leading cause of death globally<\/strong>. In 2018, cancer is estimated to contribute to 9.6 million deaths worldwide [1]. <\/p>\n\n\n\n
So what exactly is cancer?\nWhere does it come from?<\/strong> <\/p>\n\n\n\n
Our\ncells are constantly multiplying themselves to replace those that are lost\nthrough damage and natural cell death. When cells are lost, new ones are formed\nto replace them. <\/p>\n\n\n\n
However,\nsometimes this process breaks down and the body produces abnormal cells instead\nof healthy ones. Occasionally these abnormal cells become cancerous and will\nbegin to self-replicate and spread. <\/p>\n\n\n\n
What went wrong? What causes\nthe formation of these abnormal and potentially cancerous cells?<\/strong><\/p>\n\n\n\n
It\nall starts with our DNA. <\/p>\n\n\n\n
Our\nDNA is responsible for providing the blueprints to manufacture a new cell. The\nbody references these blueprints every time a new cell is made. If the DNA\nbecomes damaged, it can cause issues with the replication process \u2014 producing\nabnormal, or dysfunctional cells instead of healthy ones. <\/p>\n\n\n\n
These dysfunctional cells can\neither be cancerous, or non-cancerous<\/strong> \u2014 however, both\nmay start replicating themselves to produce more abnormal cells \u2014 eventually\nforming large \u201ccolonies\u201d of abnormal cells known as tumors. <\/p>\n\n\n\n
Non-cancerous\n(benign) tumors remain confined to the affected organ and their growth is generally slow. They\neventually become cut off from the rest of the body as healthy cells begin to\ngrow around the tumor in order to keep the organ functioning properly. These\ntumors are rarely fatal if caught early. They only become dangerous when the\ntumor grows so large it begins pressing on other organs \u2014 impeding their\nfunction. <\/p>\n\n\n\n
Cancerous (malignant) tumors\nare very different. <\/strong>Instead of forming tumors that are\ncut off from the rest of the body, they integrate themselves into new\nareas \u2014 spreading the dysfunctional cell types to other organs and\ntissues. This is referred to as\n\u201cmetastasis\u201d. <\/strong><\/p>\n\n\n\n
Cancer\ncells have a certain \u201cintelligence\u201d to them \u2014 replicating themselves\nrelentlessly, even forming their own blood vessels to feed the energy-intensive\ngrowth of the tumor. Some cancers will even take measures to resist the effects\nof chemotherapy medications designed to kill them. <\/p>\n\n\n\n
Cancer Cells Can Resist Chemotherapy a Few Different Ways: <\/h4>\n\n\n\n
- By pumping the chemotherapy agent out of the\n cancerous cells<\/strong><\/li>
- By blocking the protein\n on the cancer cell wall that lets the chemotherapy agent in<\/strong><\/li>
- By deactivating the\n chemotherapy agent before it can take effect<\/strong><\/li>
- By quickly repairing the damage caused by the chemotherapeutic\n agent<\/strong><\/li><\/ol>\n\n\n\n
This type of cell dysfunction can be very dangerous \u2014 resisting attacks from the immune system, and spreading to new areas of the body. <\/p>\n\n\n\n
Cancer is Not a Single Disease<\/h3>\n\n\n\n
According to the National Cancer Institute<\/a>, there are more than 100 different types of cancer. Each type is characterized by the organ cancer first originated in. For example, lung cancer originates in the lungs, while skin cancer starts in the skin. <\/p>\n\n\n\n
Cancer\ncan also be characterized by the type<\/em>\nof cell that forms the tumor.<\/p>\n\n\n\n
Each\ntype of cancer is unique and may require different treatments but the general\nconcept is the same \u2014 to stop the spread of cancer cells by interrupting their\nability to replicate themselves. This is the primary goal of chemotherapy\nmedications. <\/p>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cancer-1-1024x512.jpg\")
<\/figure><\/div>\n\n\n\nWhat is CBD?<\/h2>\n\n\n\n
Cannabidiol (CBD) is just one out of the 400 compounds found in the cannabis plant. There are two primary therapeutic compounds contained within the leaves and flowers of the plant \u2014 THC, and CBD. These compounds are closely related but have some key differences in their effects. <\/p>\n\n\n\n
1. THC is the primary psychoactive component of cannabis<\/strong> and although it has beneficial pain-relieving and anti-inflammatory effects, it can also cause some unwanted side effects such as cognitive impairment, anxiety, sedation, dizziness, dry mouth, and\/or eyes, psychosis, and poor motor coordination. <\/p>\n\n\n\n
Pharmaceuticals like\nDronabinol and Nabilone are synthetic versions of THC used as adjunctive\ntreatments for cancer patients. <\/p>\n\n\n\n
2. CBD is the primary non-psychoactive component of cannabis<\/strong> and has been shown to have neuroprotective, anti-inflammatory, anxiolytic, and antipsychotic therapeutic actions without the typical mind-altering side effects of THC (more on this below).<\/p>\n\n\n\n
Recent studies have shown that CBD exhibits anticancer activity <\/strong>in many types of cancer such as colorectal (colon), breast, lung, prostate, glioblastoma, melanoma, leukemia, and neuroblastoma [5<\/a>].<\/p>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/anxious-cancer-CBD-condition.jpg\")
<\/figure><\/div>\n\n\n\nHow Are Cancer Patients Using\nCBD?<\/h2>\n\n\n\n
This article is intended for informational use only \u2014 always speak with your doctor<\/a> before using CBD or any other supplement. <\/strong><\/p>\n\n\n\n
There\nare a lot of people these days using supplements like CBD to support their\nimmune system, and address some of the most common side-effects of cancer and\nchemotherapy. <\/p>\n\n\n\n
Side\neffects patients may experience range from weight loss, fatigue, peripheral\nneuropathy, mouth ulcers, blisters, and hair loss. <\/p>\n\n\n\n
Widespread research has shown CBD to have a high level of safety \u2014\u00a0even in combination with other pharmaceutical medications [31<\/a>]. However, CBD does interact with some medications<\/a>.<\/p>\n\n\n\n
The most common method of taking CBD oil is oral. This allows an easily administered form of the supplement, allows users to measure dosages accurately, and has a relatively high absorption rate compared to other methods.<\/p>\n\n\n\n
CBD can also be taken in capsule form<\/a>, used topically (such as with skin cancer), disguised in beverages, or baked into food.<\/p>\n\n\n\n
Most\nof the research on using CBD and other cannabinoids with other cancer therapies\ninvolved higher doses than other health conditions. Speak with your doctor about the right dose, and remain consistent with\nthe dosage regimen for best results. <\/strong><\/p>\n\n\n\n
![\"\"](\"http:\/\/dailycbd.com\/en\/wp-content\/uploads\/sites\/7\/2018\/11\/cancer-3.jpg\")
<\/figure><\/div>\n\n\n\nKey Takeaways: Using CBD With Cancer <\/h2>\n\n\n\n
Research\ninvolving CBD has shown a lot of promise as an adjunctive treatment with cancer\npatients \u2014 however, more research is\nneeded to prove these effects in practice. <\/strong><\/p>\n\n\n\n
The\nmajority of the research on this application involves in vitro research animal\ntesting, and small group human research trials.<\/p>\n\n\n\n
The\nbenefit of this useful health supplement lies in its ability to interact with\nthe endocannabinoid system \u2014 which is deeply connected with the inflammatory\nresponse, and other aspects of the immune system including the balance between\nTH1 and TH2 responses. <\/p>\n\n\n\n
CBD may also provide benefits to some of the common side-effects of chemotherapy and cancer such as nausea, vomiting, pain, insomnia, anxiety, and depression. <\/p>\n\n\n\n
With its long list of therapeutic benefits and a widespread lack of substantial risk or side effects<\/a>, CBD is an exciting new prospect for cancer treatment. We\u2019ll be sure to share any developments in this area as they\u2019re published in the scientific literature. <\/p>\n\n\n\n
\n\n\n\nReferences Cited in This Article<\/h2>\n\n\n\n
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- Shurin, M. R., Lu, L., Kalinski, P., Stewart-Akers, A. M., & Lotze, M. T. (1999, December). Th1\/Th2 balance in cancer, transplantation and pregnancy. In Springer seminars in immunopathology (Vol. 21, No. 3, pp. 339-359). Springer-Verlag.<\/li>
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- Aviello, G., Romano, B., Borrelli, F., Capasso, R., Gallo, L., Piscitelli, F., … & Izzo, A. A. (2012). Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. Journal of molecular medicine, 90(8), 925-934.<\/li>
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- Machado Bergamaschi, M., Helena Costa Queiroz, R., Waldo Zuardi, A., & Crippa, A. S. (2011). Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current drug safety, 6(4), 237-249.<\/li>
- Shurin, M. R., Lu, L., Kalinski, P., Stewart-Akers, A. M., & Lotze, M. T. (1999, December). Th1\/Th2 balance in cancer, transplantation and pregnancy. In Springer seminars in immunopathology (Vol. 21, No. 3, pp. 339-359). Springer-Verlag.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"
Studies have shown that CBD oil can help relieve nausea and pain in cancer patients. <\/p>\n
So how does it work and how is it taken? <\/p>\n
Can CBD really help with cancer?<\/p>\n","protected":false},"author":10,"featured_media":861,"parent":0,"menu_order":57,"template":"","crb_condition_category":[49],"yoast_head":"\n
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(2012). Das therapeutische Potenzial von Cannabis und Cannabinoiden. Deutsches Arzteblatt International<\/em>, 109<\/em>(29\u201330), 495\u2013501. https:\/\/doi.org\/10.3238\/arztebl.2012.0495<\/li>
- By blocking the protein\n on the cancer cell wall that lets the chemotherapy agent in<\/strong><\/li>
- By pumping the chemotherapy agent out of the\n cancerous cells<\/strong><\/li>
- CBD may alleviate cancer-related pain<\/strong><\/li>